Research progress of NKG2D and its ligands in treatment of gastric cancer

doi:10.3760/cma.j.issn.1007-1245.2023.20.007

Abstract

Abstract:

Natural killer cell 2D (NKG2D) and its ligands play an important role in the recognition, initiation, enhancement, or inhibition of lymphocyte effects in NK cells. In recent years, the NKG2D receptor on NK cells has become a hot research topic with the deepening of tumor immune evasion research. As a serious disease affecting human life span, gastric cancer's treatment has been a difficult problem. In recent years, major breakthroughs have been made in the immunotherapy of cancer. NKG2D and its ligands may be a potential direction of immunotherapy. Therefore, this paper reviews the research progress of NKG2D and its ligands in the treatment of gastric cancer.

Key words:

Gastric cancer, NK cells, Tumor immunity, Immune evasion, NKG2D, Progress

摘要：

自然杀伤细胞2D（natural killer cell 2D，NKG2D）及其配体在NK细胞识别、启动、增强或抑制淋巴细胞效应功能上发挥着重要作用。近年来，随着肿瘤免疫逃避研究的深入，NK细胞上的NKG2D受体成为一个研究热门。胃癌作为严重影响人类寿命的疾病，其治疗一直是难以突破的难题。近年来，针对癌症的免疫治疗取得了重大突破。NKG2D及其配体可能是一个潜在的免疫治疗方向，故本文综述了NKG2D及其配体治疗胃癌的研究进展。

关键词:

胃癌, NK细胞, 肿瘤免疫, 免疫逃避, NKG2D, 进展

Li Zongrui, Liu Weipeng, Hu Baoguang.

Research progress of NKG2D and its ligands in treatment of gastric cancer [J]. International Medicine and Health Guidance News, 2023, 29(20): 2852-2856.

李宗睿刘为朋胡宝光.

NKG2D及其配体治疗胃癌的研究进展 [J]. 国际医药卫生导报, 2023, 29(20): 2852-2856.

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