Research progress of autoimmune factors in premature ovarian failure

doi:10.3760/cma.j.issn.1007-1245.2023.20.002

International Medicine and Health Guidance News ›› 2023, Vol. 29 ›› Issue (20): 2829-2833.DOI: 10.3760/cma.j.issn.1007-1245.2023.20.002

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Research progress of autoimmune factors in premature ovarian failure

Fan Yuhan¹, Liu Ziqin², Zhu Yue², Cui Shuna^2,3

¹Clinical Department, Medical College, Yangzhou University, Yangzhou 225009, China; ²Department of Chinese and Western Medicine, Medical College, Yangzhou University, Yangzhou 225009, China; ³Department of Gynaecology and Obstetrics, Hospital Affiliated to Yangzhou University, Yangzhou 225009, China

Received:2023-05-11 Online:2023-10-15 Published:2023-11-06
Contact: Cui Shuna, Email: sncui@yzu.edu.cn
Supported by:
Special Science and Technology Project of Jiangsu Provincial Administration of Traditional Chinese Medicine (2020ZX21); Project of Innovation Program for Graduates in Jiangsu Province (SJCX22_1833); Project of "Qinglan Program" in Jiangsu Province (2022); "High Talent Project" of Yangzhou University (2020); Project of Practice and Innovation Training Program for Undergraduates of Yangzhou University (X20220745)

自身免疫因素在卵巢早衰中的研究进展

樊雨邗¹ 刘子沁² 朱悦² 崔树娜^2,3

¹扬州大学医学院临床医学系，扬州　225009；²扬州大学医学院中西医结合学系，扬州　225009；³扬州大学附属医院妇产科，扬州　225009

通讯作者: 崔树娜，Email：sncui@yzu.edu.cn
基金资助:
江苏省中医药管理局科技专项（2020ZX21）；江苏省研究生创新工程项目（SJCX22_1833）；江苏省“青蓝工程”项目（2022）；扬州大学高端人才项目（2020）；扬州大学大学生实践创新训练计划项目（X20220745）

Abstract

Abstract:

Premature ovarian failure refers to the cessation of ovarian function in women before the age of 40. It is characterized by amenorrhea with a high gonadotropin level and a low estrogen level. The diagnostic criteria are as below: the duration of amenorrhea is more than 4-6 months; two consecutive tests with the interval of more than 4 weeks showed FSH > 40 U/L. Premature ovarian failure affects the quantity and quality of oocytes, leading to the decline or even loss of female fertility, and endangers women's health. However, the cause of premature ovarian failure is unknown and may be related to a variety of factors, such as genetic factors, environmental factors, age factors, immune factors, iatrogenic factors, etc. Among them, the immune factors have a complicated mechanism acting on this disease. Therefore, the immune factors involved in premature ovarian failure are summarized in this paper to provide diagnosis and treatment ideas for its clinical prevention and treatment.

Key words:

Ovarian reserve, Premature ovarian failure, Autoimmunity, Antibody, Cytokines

摘要：

卵巢早衰（premature ovarian failure，POF）是指女性在40岁前卵巢功能衰竭，以闭经伴高促性腺激素和低雌激素为特征，其诊断标准为：闭经时间超过4～6个月、间隔>4周连续2次测出卵泡刺激素（follicle-stimulating hormone，FSH）>40 U/L。POF影响卵母细胞的数量和质量，导致女性生育能力减退甚至丧失，危害女性健康。导致POF的原因不明，可能与多种因素有关，如遗传性因素、环境因素、年龄因素、自身免疫因素、医源性因素等，其中自身免疫因素作用于该疾病的机制错综复杂，且影响日益受人们的重视。因此，本文将POF涉及的自身免疫因素整理如下，为临床上该疾病的预防和治疗提供诊疗思路。

关键词:

卵巢储备, 卵巢早衰, 自身免疫, 抗体, 细胞因子

Fan Yuhan, Liu Ziqin, Zhu Yue, Cui Shuna.

Research progress of autoimmune factors in premature ovarian failure [J]. International Medicine and Health Guidance News, 2023, 29(20): 2829-2833.

樊雨邗刘子沁朱悦崔树娜.

自身免疫因素在卵巢早衰中的研究进展 [J]. 国际医药卫生导报, 2023, 29(20): 2829-2833.

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Research progress of autoimmune factors in premature ovarian failure

自身免疫因素在卵巢早衰中的研究进展

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