Research progress of GSDMD-mediated pyrodeath in atrial fibrillation

doi:10.3760/cma.j.issn.1007-1245.2023.20.001

Abstract

Abstract:

Pyroptosis is a programmed death mode recently discovered. Its pathways include the classical pyroptosis pathway, non-classical pyroptosis pathway, other caspase-mediated pyroptosis pathway, and granulozyme mediated pathway. Gasdermin protein (GSDM) is the final efficient protein. GSDMD is one of the Gasdermin pore-forming proteins that have been studied extensively and deeply. Pyrodeath is associated with chronic inflammatory diseases, tumors, atherosclerotic diseases, metabolic diseases, and neurodegenerative diseases. In recent years, it is found that pyrodeath involves in the cardiovascular field, but the research on atrial fibrillation is still in its infancy. Further research on the mechanism of pyrodeath in atrial fibrillation may become one of the effective strategies for atrial fibrillation in the future.

Key words:

Pyrocytosis, Atrial fibrillation, GSDMD, Progress

摘要：

细胞焦亡是近期发现的一种程序性死亡方式，其途径有经典焦亡途径、非经典焦亡途径、其他半胱氨酸天冬酶（caspase）介导的细胞焦亡途径以及颗粒酶介导的途径。消皮素蛋白（gasdermin，GSDM）是最终的效应蛋白，其中消皮素D（GSDMD）是gasdermin成孔蛋白家族中目前研究最为广泛和深入的一类蛋白。细胞焦亡与慢性炎性疾病、肿瘤、动脉粥样硬化性疾病、代谢性疾病以及神经退行性疾病相关。近年来，细胞焦亡在心血管领域也有所涉及，但在心房颤动（atrial fibrillation，AF）方面的研究仍处于刚刚起步阶段，进一步研究细胞焦亡在房颤中的作用机制可能成为未来对AF的有效策略。

关键词:

细胞焦亡, 心房颤动, GSDMD, 进展

Shang Xue, Zhao Jiahao, Li Xinxi, Zhu Hui, Zhao Ke, Liu Zhenxing, Xu Huipu.

Research progress of GSDMD-mediated pyrodeath in atrial fibrillation [J]. International Medicine and Health Guidance News, 2023, 29(20): 2825-2828.

商雪赵嘉昊李昕玺祝慧赵珂刘振兴徐会圃.

GSDMD介导的细胞焦亡在心房颤动中的研究进展 [J]. 国际医药卫生导报, 2023, 29(20): 2825-2828.

References

[1] Wang X, Fu Q, Song F, et al. Prevalence of atrial fibrillation in different socioeconomic regions of China and its association with stroke: results from a national stroke screening survey[J]. Int J Cardiol, 2018 ,271:92-97. DOI: 10.1016/j.ijcard.2018.05.131.
[2] Chua W, Law JP, Cardoso VR, et al. Quantification of fibroblast growth factor 23 and N-terminal pro-B-type natriuretic peptide to identify patients with atrial fibrillation using a high-throughput platform: a validation study[J]. PLoS Med, 2021 ,18(2):e1003405. DOI: 10.1371/journal.pmed.1003405.
[3] Wang X, Fu Q, Song F, et al. Prevalence of atrial fibrillation in different socioeconomic regions of China and its association with stroke: Results from a national stroke screening survey[J]. Int J Cardiol, 2018 ,271:92-97. DOI: 10.1016/j.ijcard.2018.05.131.
[4] 王一斐,张萍. 心房颤动与炎症反应之交互关系[J]. 中国心血管杂志,2023,28(1):62-66. DOI:10.3969/j.issn.1007-5410.2023.01.013.
[5] Chang G, Chen Y, Liu Z,et al. The PD-1 with PD-L1 axis is pertinent with the immune modulation of atrial fibrillation by regulating T cell excitation and promoting the secretion of inflammatory factors[J]. J Immunol Res, 2022 ,2022:3647817. DOI: 10.1155/2022/3647817.
[6] Yao C, Veleva T, Scott L, et al. Enhanced cardiomyocyte NLRP3 inflammasome signaling promotes atrial fibrillation[J]. Circulation, 2018,138(20):2227-2242. DOI: 10.1161/CIRCULATIONAHA.118.035202.
[7] 李彬,李泱,陈雅婷,等. 核苷酸结合寡聚化结构域样受体蛋白3炎性小体在肥胖相关心房颤动发病中的研究进展[J]. 中华老年心脑血管病杂志,2023,25(1):99-101. DOI:10.3969/j.issn.1009-0126.2023.01.026.
[8] 谢红英,张小群,罗晓丽,等. Nod样受体蛋白3与非瓣膜性心房颤动患者左心房血栓形成的相关性[J]. 中华老年心脑血管病杂志,2019,21(10):1036-1040. DOI:10.3969/j.issn.1009-0126.2019.10.008.
[9] Zychlinsky A, Prevost MC, Sansonetti PJ. Shigella flexneri induces apoptosis in infected macrophages[J]. Nature,1992,358(6382):167-169. DOI: 10.1038/358167a0.
[10] Frank D, Vince JE. Pyroptosis versus necroptosis: similarities, differences, and crosstalk[J]. Cell Death Differ, 2019 ,26(1):99-114. DOI: 10.1038/s41418-018-0212-6.
[11] Shi J, Zhao Y, Wang K, et al. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death[J]. Nature, 2015 ,526(7575):660-665. DOI: 10.1038/nature15514.
[12] Galluzzi L, Vitale I, Aaronson SA, et al. Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018[J]. Cell Death Differ, 2018 ,25(3):486-541. DOI: 10.1038/s41418-017-0012-4.
[13] Shi J, Gao W, Shao F. Pyroptosis: gasdermin-mediated programmed necrotic cell death[J]. Trends Biochem Sci, 2017 ,42(4):245-254. DOI: 10.1016/j.tibs.2016.10.004.
[14] Fang Y, Tian S, Pan Y, et al. Pyroptosis: a new frontier in cancer[J]. Biomed Pharmacother, 2020 ,121:109595. DOI: 10.1016/j.biopha.2019.109595.
[15] 梅旦,张玲玲,魏伟. 细胞焦亡机制及与疾病的关系[J]. 生理科学进展,2020,51(2):151-156. DOI:10.3969/j.issn.0559-7765.2020.02.018.
[16] Wang Y, Gao W, Shi X, et al. Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin[J]. Nature, 2017 ,547(7661):99-103. DOI: 10.1038/nature22393.
[17] Donado CA, Cao AB, Simmons DP, et al. A two-cell model for IL-1β release mediated by death-receptor signaling[J]. Cell Rep, 2020 ,31(1):107466. DOI: 10.1016/j.celrep.2020.03.030.
[18] Demarco B, Grayczyk JP, Bjanes E, et al. Caspase-8-dependent gasdermin D cleavage promotes antimicrobial defense but confers susceptibility to TNF-induced lethality[J]. Sci Adv, 2020 ,6(47):eabc3465. DOI: 10.1126/sciadv.abc3465.
[19] Zhou Z, He H, Wang K, et al. Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells[J]. Science, 2020 ,368(6494):eaaz7548. DOI: 10.1126/science.aaz7548.
[20] Zhang Z, Zhang Y, Xia S, et al. Gasdermin E suppresses tumour growth by activating anti-tumour immunity[J]. Nature, 2020 ,579(7799):415-420. DOI: 10.1038/s41586-020-2071-9.
[21] Tamura M, Tanaka S, Fujii T, et al. Members of a novel gene family, Gsdm, are expressed exclusively in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner[J]. Genomics, 2007 ,89(5):618-629. DOI: 10.1016/j.ygeno.2007.01.003.
[22] Liu Z, Wang C, Yang J, et al. Crystal structures of the full-length murine and human gasdermin D reveal mechanisms of autoinhibition, lipid binding, and oligomerization[J]. Immunity, 2019 ,51(1):43-49.e4. DOI: 10.1016/j.immuni.2019.04.017.
[23] He WT, Wan H, Hu L, et al. Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion[J]. Cell Res, 2015 ,25(12):1285-1298. DOI: 10.1038/cr.2015.139.
[24] Xia S, Hollingsworth LR 4th, Wu H. Mechanism and regulation of gasdermin-mediated cell death[J]. Cold Spring Harb Perspect Biol, 2020 ,12(3):a036400. DOI: 10.1101/cshperspect.a036400.
[25] Rodríguez-Antonio I, López-Sánchez GN, Uribe M, et al. Role of the inflammasome, gasdermin D, and pyroptosis in non-alcoholic fatty liver disease[J]. J Gastroenterol Hepatol, 2021 ,36(10):2720-2727. DOI: 10.1111/jgh.15561.
[26] Hu S, Wang L, Xu Y, et al. Disulfiram attenuates hypoxia-induced pulmonary hypertension by inhibiting GSDMD cleavage and pyroptosis in HPASMCs[J]. Respir Res, 2022 ,23(1):353. DOI: 10.1186/s12931-022-02279-0.
[27] Hu JJ, Liu X, Xia S, et al. FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation[J]. Nat Immunol, 2020 ,21(7):736-745. DOI: 10.1038/s41590-020-0669-6.
[28] Lippi G, Sanchis-Gomar F, Cervellin G. Global epidemiology of atrial fibrillation: an increasing epidemic and public health challenge[J]. Int J Stroke, 2021 ,16(2):217-221. DOI: 10.1177/1747493019897870.
[29] Mukherjee K, Kamal KM. Impact of atrial fibrillation on inpatient cost for ischemic stroke in the USA[J]. Int J Stroke, 2019 ,14(2):159-166. DOI: 10.1177/1747493018765491.
[30] Leonelli Fabio,Bagliani Giuseppe,Boriani Giuseppeet al. Arrhythmias Originating in the Atria.[J] .Card Electrophysiol Clin, 2017, 9: 383-409.
[31] Harada M, Nattel S. Implications of inflammation and fibrosis in atrial fibrillation pathophysiology[J]. Card Electrophysiol Clin, 2021 ,13(1):25-35. DOI: 10.1016/j.ccep.2020.11.002.
[32] Yan B, Liu T, Yao C, et al. LncRNA XIST shuttled by adipose tissue-derived mesenchymal stem cell-derived extracellular vesicles suppresses myocardial pyroptosis in atrial fibrillation by disrupting miR-214-3p-mediated Arl2 inhibition[J]. Lab Invest, 2021 ,101(11):1427-1438. DOI: 10.1038/s41374-021-00635-0.
[33] Chen G, Chelu MG, Dobrev D, et al. Cardiomyocyte inflammasome signaling in cardiomyopathies and atrial fibrillation: mechanisms and potential therapeutic implications[J]. Front Physiol, 2018 ,9:1115. DOI: 10.3389/fphys.2018.01115.
[34] Yan B, Liu T, Yao C, et al. LncRNA XIST shuttled by adipose tissue-derived mesenchymal stem cell-derived extracellular vesicles suppresses myocardial pyroptosis in atrial fibrillation by disrupting miR-214-3p-mediated Arl2 inhibition[J]. Lab Invest, 2021 ,101(11):1427-1438. DOI: 10.1038/s41374-021-00635-0.
[35] Li N, Brundel BJJM. Inflammasomes and proteostasis novel molecular mechanisms associated with atrial fibrillation[J]. Circ Res, 2020 ,127(1):73-90. DOI: 10.1161/CIRCRESAHA.119.316364.
[36] Heijman J, Muna AP, Veleva T, et al. Atrial myocyte NLRP3/CaMKII nexus forms a substrate for postoperative atrial fibrillation[J]. Circ Res, 2020 ,127(8):1036-1055. DOI: 10.1161/CIRCRESAHA.120.316710.
[37] Song L, Pei L, Yao S, et al. NLRP3 inflammasome in neurological diseases, from functions to therapies[J]. Front Cell Neurosci, 2017 ,11:63. DOI: 10.3389/fncel.2017.00063.
[38] Shen HH, Yang YX, Meng X, et al. NLRP3: a promising therapeutic target for autoimmune diseases[J]. Autoimmun Rev, 2018 ,17(7):694-702. DOI: 10.1016/j.autrev.2018.01.020.
[39] Wei X, Xie F, Zhou X, et al. Role of pyroptosis in inflammation and cancer[J]. Cell Mol Immunol, 2022 ,19(9):971-992. DOI: 10.1038/s41423-022-00905-x.
[40] Zeng C, Wang R, Tan H. Role of pyroptosis in cardiovascular diseases and its therapeutic implications[J]. Int J Biol Sci, 2019 ,15(7):1345-1357. DOI: 10.7150/ijbs.33568.
[41] 王佳慧,梁欢,于影,等. 细胞焦亡与心血管疾病的研究进展[J]. 生理学报,2021,73(2):329-341. DOI:10.13294/j.aps.2020.0063.