Immunogenicity and influencing factors of measles-mumps-rubella combined
vaccine and cognition of vaccination in recruits

doi:10.3760/cma.j.issn.1007-1245.2022.08.013

Abstract

Abstract:

Objective　To evacuate the immunogenicity of measles-mumps-rubella combined vaccine (MMR), explore its influencing factors, and survey the attitude to vaccination in recruits. Methods　The cluster sampling method was used to select recruits from two boot camps stationed in Guangdong in September 2017 as the research objects. A total of 396 people from the boot camp 1 were selected to study the immunogenicity and influencing factors of MMR, and a cognitive survey of vaccine was conducted in 473 people from the boot camp 2. The recruits' antibody titers before and after MMR vaccination were tested, and a questionnaire survey was conducted. χ² test was used to analyze the difference of antibody positive rate before and after vaccination. After data transformation, normality test, and homogeneity test of variance, the antibody geometric mean concentration (GMC) was statistically analyzed by independent sample t test or F test. Results　After MMR vaccination, the antibody positive conversion rates of measles, mumps, and rubella in the 396 people from the boot camp 1 were 100.00%, and the antibody GMC of measles, mumps, and rubella were 1 191.67 mIU/ml, 1 663.62 U/ml, and 144.59 IU/ml respectively, which were 1.73 times, 4.79 times, and 4.09 times of those before vaccination. The antibody levels after vaccination were significantly higher than those before vaccination (all P<0.05). After vaccination, the antibody GMC of the soldiers with negative antibody before vaccination was lower than those with positive antibody before vaccination, and the difference was statistically significant in the mumps and rubella (both P<0.05). The study found that age, nationality, education background, place of enlistment, family economic status, smoking, drinking, work before enlistment, intimate contact with the opposite sex, and chronic gastroenteritis had no significant effects on the antibody concentration after MMR vaccination. According to the survey, the vast majority of people in the boot camp 2 wanted to know the knowledge related to the vaccine [97.25% (460/473)] and believed that vaccination could effectively prevent the corresponding diseases [90.49% (428/473)], but only 72.52% (343/473) were willing to inoculate vaccine. The main reason for their reluctance was vaccine safety (53.85%). Conclusions　Domestic MMR can produce good immunogenicity in recruits. Vaccine security events make a negative influence on vaccination willingness, and the publicity and education of vaccination in troops should be strengthened.

Key words: Recruits, MMR, Immunogenicity, Influencing factors, Cognition

摘要： 目的　了解部队新兵接种麻腮风疫苗（MMR）的免疫效果、影响因素及对预防接种的态度。方法　采用整群抽样的方法选择驻广东某部2017年9月入伍的2个新兵营作为研究对象。选择新兵营一396人开展麻腮风联合减毒活疫苗免疫效果及影响因素研究，选择新兵营二473人开展疫苗的认知调查。对新兵接种MMR前后的抗体滴度进行检测，并开展问卷调查。用χ²检验分析疫苗接种前后抗体阳性率之间差异，抗体几何平均浓度（GMC）进行数据变换、正态性检验和方差齐性检验后用独立样本t检验或F检验进行统计分析。结果　MMR接种后，新兵营一396人麻疹、腮腺炎和风疹抗体阳转率均为100.00%；MMR接种后麻疹、腮腺炎和风疹GMC分别为1 191.67 mIU/ml、1 663.62 U/ml和144.59 IU/ml，是接种前的1.73倍、4.79倍和4.09倍，接种后抗体水平显著高于接种前（均P<0.05）；接种前抗体阴性的新兵接种后抗体GMC低于接种前抗体阳性的新兵，其中腮腺炎和风疹差异均有统计学意义（均P<0.05）。研究中没有发现年龄、民族、学历、入伍地、家庭经济状况、吸烟、喝酒、入伍前工作、与异性有过亲密接触、有慢性胃肠炎对MMR接种后的抗体浓度产生影响。调查显示，新兵营二绝大多数官兵希望了解与疫苗有关的知识97.25%（460/473），认为接种疫苗能有效预防相应疾病90.49%（428/473），但愿意接种疫苗的仅72.52%（343/473），不愿意接种的主要原因为疫苗安全问题（53.85%）。结论　国产MMR在新兵中接种能产生良好的免疫效果；疫苗安全事件影响官兵的接种意愿，应加强宣教。

关键词: 新兵, 麻腮风疫苗, 免疫效果, 影响因素, 认知

Xie Xiaobo, Yu Dexian, Liu Wenyi, Yang Yang. Immunogenicity and influencing factors of measles-mumps-rubella combined vaccine and cognition of vaccination in recruits[J]. International Medicine and Health Guidance News, 2022, 28(8): 1093-1098.

谢晓波, 于德宪, 刘文毅, 杨阳. 新兵接种麻腮风疫苗的免疫效果、影响因素及认知研究[J]. 国际医药卫生导报, 2022, 28(8): 1093-1098.

References

[1] 曹玮民,唐玥,常国辉,等. 重组乙肝疫苗在部队人群中免疫效果观察[J]. 解放军预防医学杂志,2016,34(3):327-330,334. DOI:10.13704/j.cnki.jyyx.2016.03.009.

[2] Brewer JM. State of the world's vaccines and immunization[J]. Trans R Soc Trop Med Hyg,2003,9(2):181. DOI:10.1016/S0035-9203(03)90113-1.

[3] 刘国华,方悍华,冯子健,等. 冻干麻疹-腮腺炎-风疹三联活疫苗免疫安全性及免疫学效果观察[J]. 中华流行病学杂志,2002,23(6):435-437. DOI:10.3760/j.issn:0254-6450. 2002.06.007.

[4] 丁亚兴,刘杨,徐恩媛,等. 麻腮风联合减毒活疫苗在儿童复种和育龄期女性接种的免疫效果和安全性观察[J]. 中国疫苗和免疫,2017,23(4):365-368.

[5] 章光明,朱淑英,吴晓虹. 浙江省金华市人群麻疹、腮腺炎、水痘、乙型病毒性肝炎和甲型病毒性肝炎抗体水平监测分析[J]. 疾病监测,2016,31(12):1033-1036.

[6] 何寒青,李倩,严睿,等. 儿童接种不同免疫程序国产麻疹-流行性腮腺炎-风疹联合减毒活疫苗后3年抗体持久性分析[J]. 中华预防医学杂志,2017,51(4):336-340. DOI:10.3760/cma.j.issn.0253-9624.2017.04.011.

[7] Querec TD, Akondy RS, Lee EK, et al. Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans[J].Nat Immunol,2009,10(1):116-125. DOI:10.1038/ni.1688.

[8] Ritz N, Mui M, Balloch A, et al. Non-specific effect of Bacille Calmette-Guérin vaccine on the immune response to routine immunisations[J].Vaccine,2013,31(30):3098-3103. DOI:10.1016/j.vaccine.2013.03.059.

[9] Nakaya HI, Hagan T, Duraisingham SS, et al. Systems analysis of immunity to influenza vaccination across multiple years and in diverse populations reveals shared molecular signatures[J].Immunity,2015,43(6):1186-1198. DOI:10.1016/j.immuni.2015.11.012.

[10] Junqueira AL, Tavares VR, Martins RM, et al. Safety and immunogenicity of hepatitis B vaccine administered into ventrogluteal vs. anterolateral thigh sites in infants: a randomised controlled trial[J].Int J Nurs Stud,2010,47(9):1074-1079. DOI:10.1016/j.ijnurstu.2010.01.009.

[11] Grassly NC, Kang G, Kampmann B. Biological challenges to effective vaccines in the developing world[J].Philos Trans R Soc Lond B Biol Sci,2015,370(1671):20140138. DOI:10.1098/rstb.2014.0138.

[12] Zimmermann P, Curtis N. Factors that influence the immune response to vaccination[J].Clin Microbiol Rev,2019,32(2):e00084-e00018. DOI:10.1128/CMR.00084-18.

[13] Yang S, Tian G, Cui Y, et al. Factors influencing immunologic response to hepatitis B vaccine in adults[J].Sci Rep,2016,6:27251. DOI:10.1038/srep27251.

[14] Namujju PB, Pajunen E, Simen-Kapeu A, et al. Impact of smoking on the quantity and quality of antibodies induced by human papillomavirus type 16 and 18 AS04-adjuvanted virus-like-particle vaccine - a pilot study[J].BMC Res Notes,2014,7:445. DOI:10.1186/1756-0500-7-445.

[15] Tohme RA, Awosika-Olumo D, Nielsen C, et al. Evaluation of hepatitis B vaccine immunogenicity among older adults during an outbreak response in assisted living facilities[J].Vaccine,2011,29(50):9316-9320. DOI:10.1016/j.vaccine.2011.10.011.

[16] van Riet E, Retra K, Adegnika AA, et al. Cellular and humoral responses to tetanus vaccination in Gabonese children[J].Vaccine,2008,26(29-30):3690-3695. DOI:10.1016/j.vaccine.2008.04.067.

[17] Naylor C, Lu M, Haque R, et al. Environmental enteropathy, oral vaccine failure and growth faltering in infants in Bangladesh[J].EBioMedicine,2015,2(11):1759-1766. DOI:10.1016/j.ebiom.2015.09.036.

[18] World Health Organization. Global measles and rubella strategies plan: 2012-2020[M]. Geneva:WHO,2012.

[19] Roberts L. Is measles next? [J].Science,2015,348(6238):958-961,963. DOI:10.1126/science.348.6238.958.

[20] Mulders MN, Rota PA, Icenogle JP, et al. Global measles and rubella laboratory network support for elimination goals, 2010-2015[J].MMWR Morb Mortal Wkly Rep,2016,65(17):438-442. DOI:10.15585/mmwr.mm6517a3.

[21] 李硕,张云辉,王永怡,等. 2019年1—2月全球主要疫情回顾[J]. 传染病信息,2019,32(1):95-96. DOI:10.3969/j.issn.1007-8134.2019.01.021.

[22] 周羚,崔富强,潘毅. 重论预防接种的重要性[J]. 中华预防医学杂志,2016,50(9):755-758. DOI:10.3760/cma.j.issn.0253-9624.2016.09.002.

[23] Smith PJ, Humiston SG, Marcuse EK, et al. Parental delay or refusal of vaccine doses, childhood vaccination coverage at 24 months of age, and the Health Belief Model[J].Public Health Rep,2011,126Suppl 2(Suppl 2):135-146. DOI:10.1177/00333549111260S215.

[24] Nayar RK, Nair AT, Shaffi M, et al. Methods to overcome vaccine hesitancy[J].Lancet,2019,393(10177):1203-1204. DOI:10.1016/S0140-6736(19)30218-1.

[25] 陈琳,杨艳芳,邱露萍,等. 山东疫苗案背景下影响儿童家长预防接种信任度相关因素分析[J]. 预防医学情报杂志,2018,34(6):741-744.

[26] Salmon DA, Moulton LH, Omer SB, et al. Factors associated with refusal of childhood vaccines among parents of school-aged children: a case-control study[J].Arch Pediatr Adolesc Med,2005,159(5):470-476. DOI:10.1001/archpedi.159.5.470.

[27] Plotkin SA. Vaccines: correlates of vaccine-induced immunity[J].Clin Infect Dis,2008,47(3):401-409. DOI:10.1086/589862.

Immunogenicity and influencing factors of measles-mumps-rubella combined vaccine and cognition of vaccination in recruits

新兵接种麻腮风疫苗的免疫效果、影响因素及认知研究

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 8

Recommended Articles

Metrics

[1]	Zhang Na, Wei Wei, Xu Xinke, Chen Cheng, Sun Guifang, Tan Yonghong. Risk factors of intraoperative massive hemorrhage in children undergoing brain tumor removal [J]. International Medicine and Health Guidance News, 2022, 28(8): 1099-1103.
[2]	Zhao Yang, Zhou Jie, Geng Zhaohui. Research progress on evaluation and risk factors of cognitive frailty in hypertensive patients [J]. International Medicine and Health Guidance News, 2022, 28(6): 748-752.
[3]	Xie Sumei, Chen Hui, Chen Zhongying, Wen Qi, Liu Ting, Li Kun, Wang Tong. A mixed study on current status of sexual health needs of spinal cord injury patients based on an anthropological perspective and influencing factors [J]. International Medicine and Health Guidance News, 2022, 28(5): 651-655.
[4]	Xu Wanzhu, Luo Zebin, Chen Chujun, Wang Peiru, Hong Lichun. Status and influencing factors of discharge readiness in cancer patients [J]. International Medicine and Health Guidance News, 2022, 28(5): 734-739.
[5]	Li Kexin, Huang Meiling, Jiang Ziyan, Cai Yixiang. Investigation and analysis of current situation of high-risk early warning assessment ability for midwives in Guangzhou [J]. International Medicine and Health Guidance News, 2022, 28(4): 500-504.
[6]	Jiang Baoe, Jiang Wenting. Analysis of influencing factors and improvement measures of "missing the optimal time window for thrombolysis" in patients with acute ischemic stroke [J]. International Medicine and Health Guidance News, 2021, 27(6): 897-900.
[7]	Ma Weiwei. Analysis of humanistic care needs and influencing factors of elderly patients with primary liver cancer undergoing interventional therapy [J]. International Medicine and Health Guidance News, 2021, 27(6): 901-904.
[8]	Liu Ziwei, Guo Xiaoxia, Lin Siting, Zhang Zheng, Wang Shanshan. A review on cognition and related factors of medical staff to ERAS [J]. International Medicine and Health Guidance News, 2021, 27(6): 945-948.