Relationship between air pollutants and sepsis

doi:10.3760/cma.j.issn.1007-1245.2022.07.036

Abstract

Abstract:

Sepsis is a systemic inflammatory response syndrome caused by infection. Sepsis is dangerous and has a high mortality. At present, it is still a serious disease threatening the safety of human lives. After unremitting research, people have gradually deepened their understanding of sepsis, but it is still a dangerous condition. The research history of sepsis renal damage has been decades, and its mechanism has not been fully clarified, which may include renal ischemia-reperfusion injury, inflammatory factors, nitric oxide theory, apoptosis theory, endothelial dysfunction and endothelin effect, endotoxin direct injury, oxidative stress injury, etc. More and more evidences show that air pollution can induce infection and other diseases, so air pollution is likely to be an important risk factor for sepsis. This study discusses the effects of air pollutants on sepsis, and is expected to prevent and control the disease early so as to reduce its incidence.

Key words: Sepsis, Air pollutants, Particulate mater, Ozone

摘要： 脓毒症是一种由感染引起的全身性炎性反应综合征，脓毒症病情凶险，病死率高，在目前仍是威胁人类生命安全的重症。经过不懈研究，人们对脓毒症的认识逐步加深，但至今它仍是一凶险病情。脓毒症肾损害的研究历史已有几十年，其机制仍未完全阐明，可能包括：肾脏缺血再灌注损伤、炎症因子、一氧化氮学说、细胞凋亡学说、内皮功能障碍及内皮素作用、内毒素直接损伤及氧化应激损伤等。越来越多的证据表明空气污染可诱发感染等多种疾病，故空气污染物很可能是导致脓毒症的重要危险因素。本次探讨空气污染物对脓毒症的影响，有望对该病进行早期防控减少发病率。

关键词: 脓毒症, 空气污染物, 颗粒物, 臭氧

Chen Jing, Shi Fei. Relationship between air pollutants and sepsis[J]. International Medicine and Health Guidance News, 2022, 28(7): 1034-1036.

陈璟, 史菲. 空气污染物与脓毒症的关系研究进展[J]. 国际医药卫生导报, 2022, 28(7): 1034-1036.

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