Role of Card9 in intestinal diseases

doi:10.3760/cma.j.issn.1007-1245.2022.24.001

International Medicine and Health Guidance News ›› 2022, Vol. 28 ›› Issue (24): 3415-.DOI: 10.3760/cma.j.issn.1007-1245.2022.24.001

• Scientific Research • Next Articles

Role of Card9 in intestinal diseases

Ji Changxue¹, Yang Zhiwen²

¹Department of Vascular Intervention, Songjiang District Central Hospital, Shanghai 201600, China; ²Department of Pharmacy, Songjiang District Central Hospital, Shanghai 201600, China

Received:2022-08-25 Online:2022-12-15 Published:2022-12-17
Contact: Yang Zhiwen, Email: yangzhiwen2009@sina.com
Supported by:
National Natural Science Foundation of China (81960452); Project of Shanghai Municipal Health Commission (201940471)

Card9与肠道疾病相关性的研究进展

纪昌学¹ 杨志文²

¹上海市松江区中心医院血管介入科，上海　201600；²上海市松江区中心医院药剂科，上海　201600

通讯作者: 杨志文，Email：yangzhiwen2009@sina.com
基金资助:
国家自然科学基金项目（81960452）；上海市卫健委项目（201940471）

Abstract

Abstract: Caspase recruitment domain containing protein 9 (Card9) is an important immunoinflammatory protein distributed in the macrophages, which plays a critical role in nuclear factor (NF)-κB and MAPK activation. It leads to the initiation of inflammatory cytokine cascade, and elicits the host immune response against fungal and bacterial invasion. Current research indicates that Card9 plays an important role in regulating intestinal microecology, leading to the occurrence of various intestinal diseases. Here, we mainly focus on the function of Card9 in inflammatory bowel disease, colitis-associated colorectal cancer, and colon cancer.

Key words: Card9, Intestinal microecology, Inflammatory bowel disease, Colitis-associated colorectal cancer, Colon cancer

摘要： 胱天蛋白酶募集域蛋白9（caspase recruitment domain containing protein 9，Card9）是分布于巨噬细胞的一种重要免疫炎性蛋白，能够激活核因子（NF）-κB、MAPK炎症信号通路，参与机体抗真菌、细菌的免疫反应。近年来发现Card9参与调节肠道微生态环境，与肠道疾病具有密切的相关性。本文总结了Card9在调节肠道微生物，诱导炎性肠病、结肠炎癌变、结肠癌中的作用，为相关研究提供新思路。

关键词: Card9, 肠道微生物, 炎性肠病, 结肠炎癌变, 结肠癌

Ji Changxue, Yang Zhiwen. Role of Card9 in intestinal diseases[J]. International Medicine and Health Guidance News, 2022, 28(24): 3415-.

纪昌学杨志文. Card9与肠道疾病相关性的研究进展[J]. 国际医药卫生导报, 2022, 28(24): 3415-.

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Role of Card9 in intestinal diseases

Card9与肠道疾病相关性的研究进展

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