Role of ferroptosis in treatment of glioma

doi:10.3760/cma.j.issn.1007-1245.2022.17.003

Abstract

Abstract: Ferroptosis is a form of regulated cell death induced by iron-dependent lipid peroxide damage, and it is different from apoptosis, autophagy, and necrosis in molecular biology, morphology, and genetics. It plays an important role in the treatment of glioma, and induction of ferroptosis in glioma cells will become a new strategy for anti-tumor therapy. This article expounds the role of ferroptosis related genes, xCT, Nox4, NCOA4, and BECN1, in the treatment of glioma and the therapeutic effect of traditional Chinese medicine on ferroptosis in glioma, so as to provide new directions and ideas for the clinical treatment of glioma.

Key words: Ferroptosis, Glioma, Gene

摘要： 铁死亡是一种铁依赖性脂质过氧化物损伤诱导的调节性细胞死亡形式，其在分子生物学、形态学和遗传学等方面都不同于凋亡、自噬和坏死等细胞死亡形式。铁死亡在神经胶质瘤的治疗中发挥重要作用，诱导胶质瘤细胞铁死亡将成为治疗肿瘤的新策略。本文对铁死亡的相关基因xCT、Nox4、NCOA4、BECN1在神经胶质瘤治疗中的作用及中药在神经胶质瘤中对铁死亡的治疗作用进行阐述，以期为神经胶质瘤的临床治疗提供新方向和新思路。

关键词: 铁死亡, 神经胶质瘤, 基因

Wang Ningning, Zhu Shuxia, Zhang Yuehua. Role of ferroptosis in treatment of glioma[J]. International Medicine and Health Guidance News, 2022, 28(17): 2383-2385.

王宁宁朱淑霞张越华. 铁死亡在神经胶质瘤治疗中的作用[J]. 国际医药卫生导报, 2022, 28(17): 2383-2385.

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