Abstract: Coronary microvascular disease is a high-risk factor for a variety of cardiovascular events. Because of its complex etiology and hidden nature, its pathogenesis is still limited at this stage. In the occurrence and development of coronary microvascular endothelial cell (CMEC) dysfunction, CMEC damage is the main core link leading to its occurrence. The metabolic capacity, stress capacity, inflammation, and other related functions of CMEC are closely related to CMEC dysfunction, and it is also the main clinical feature in the early stage of its occurrence. Since the related pathological mechanism of CMEC injury has not been fully clarified at this stage, based on this, this study summarizes the related pathological mechanism of CMEC dysfunction, in order to provide a better understanding on the complex pathological mechanism of the disease for clinical medical staff, so as to provide a certain reference for the progress of subsequent related researches.

Key words: Coronary microvessels, Endothelial cells, Dysfunction, Research progress

摘要： 冠状动脉微血管疾病是多种心血管事件发生的高风险因素，因其病因较为复杂且具有一定隐蔽性，导致现阶段针对其病机机制仍较为有限。在冠状动脉微血管内皮细胞（CMEC）功能障碍的发生及发展的过程中，CMEC损伤是导致其发生的主要核心环节，CMEC的代谢能力、应激能力以及炎症等相关功能均与CMEC功能障碍疾病密切相关，同时也是其发生早期的主要临床特征。由于现阶段关于CMEC损伤的相关病理机制尚未完全明确，基于此，本研究对CMEC功能障碍的相关病理机制加以综述，以期为临床医护人员对该病发生的复杂病理机制更好理解，从而为后续相关研究的进展提供一定参考依据。

关键词: 冠状动脉微血管, 内皮细胞, 功能障碍, 研究进展