Research progress on the role of Wnt/β-catenin signaling pathway in the pathogenesis of Alzheimer's disease

doi:10.3760/cma.j.issn.1007-1245.2024.24.008

Abstract

Abstract:

Alzheimer's disease (AD) is a degenerative disease of the central nervous system, whose pathogenesis is complex and diverse. The activation of the Wnt/β-catenin signaling pathway plays a key role in regulating inflammatory responses, improving synaptic function, and anti-oxidative stress in AD. This article elaborates that the Wnt/β-catenin signaling pathway may become a new therapeutic target for AD, providing a new research direction for the treatment of AD in the future.

Key words:

Wnt/β-catenin signaling pathway, Alzheimer's disease, Pathogenesis, Neurological disorders, Progress

摘要：

阿尔茨海默病（AD）是一种中枢神经系统退行性疾病，发病机制复杂多样。在AD中，Wnt/β-catenin信号通路的激活可调节炎症反应、改善突触功能和抗氧化应激。Wnt/β-catenin信号通路可能成为治疗AD的新靶点，为AD治疗提供新的研究方向。

关键词:

Wnt/β-catenin信号通路, 阿尔茨海默病, 发病机制, 神经系统疾病, 进展

Kang Guowei, Li Xiao, Zhao Ruiqing, Feng Bo.

Research progress on the role of Wnt/β-catenin signaling pathway in the pathogenesis of Alzheimer's disease [J]. International Medicine and Health Guidance News, 2024, 30(24): 4096-4106.

康国伟李潇赵瑞清冯波.

Wnt/β-catenin信号通路对阿尔茨海默病发病机制的研究进展 [J]. 国际医药卫生导报, 2024, 30(24): 4096-4106.

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