Abstract:

Objective　To assess the clinical effect of Xiaochaihu decoction in the treatment of patients with mild recurrent oral ulcer (ROU) of Shaoyang Shishu type. Methods　A total of 120 patients with mild ROU of Shaoyang Shishu type treated at Huadu District Maternity and Child Health Hospital were selected for the randomized controlled trial, and were divided into a control group and an observation group by the random number table method, with 60 cases in each group. There were 20 males and 40 females in the control group; they were (41.42±0.41) years old; their disease course was (2.53±0.26) years. There were 22 males and 38 females in the observation group; they were (39.78±0.66) years old; their disease course was (2.11±0.71) years. Both groups were treated with Kangfuxin liquid; in addition, the observation group took Xiaochaihu decoction. The efficacies, ulcer healing time after 7 days' treatment, irritation pain duration, changes of the scores of traditional Chinese medicine (TCM) symptoms, and recurrence rates within six months after the treatment were compared between the two groups. t and χ² tests were applied. Results　The total effective rate in the observation group was higher than that in the control group [88.3% (53/60) vs. 71.7% (43/60)], with a statistical difference (χ²=5.208; P=0.022). The irritation pain duration and ulcer healing time in the observation group were shorter than those in the control group [(2.67±0.34) d vs. (4.55±0.61) d and (4.24±0.21) d vs. (7.68±0.87) d], with statistical differences (t=20.852 and 29.773; both P<0.05). After 7 days' treatment, the difference of TCM score in the observation group was lower than that in the control group (5.66±0.82 vs. 8.41±1.21), with a statistical difference (t=14.573; P<0.001). The recurrence rate within six months after the treatment in the observation group was lower than that in the control group [41.67% (25/60) vs. 80.00% (48/60)], with a statistical difference (χ²=18.502; P<0.001). Conclusion　Xiaochaihu decoction for patients with mild recurrent oral ulcer of Shaoyang Shishu type can relieve their local and systemic symptoms, and decrease the recurrence rate.

Key words:

Recurrent oral ulcer, Shaoyang Shishu, Xiaochaihu decoction, Clinical observation

摘要：

目的　探讨小柴胡汤治疗少阳失枢轻型复发性口腔溃疡（ROU）的临床疗效。方法　采用前瞻性研究，选取2023年3月至2024年2月于广州市花都区妇幼保健院就诊的少阳失枢轻型ROU患者120例作为研究对象，采用随机数字表法分为对照组（60例）和观察组（60例）。对照组男20例、女40例，年龄（41.42±0.41）岁，病程（2.53±0.26）年，采用康复新液治疗；观察组男22例、女38例，年龄（39.78±0.66）岁，病程（2.11±0.71）年，采用康复新液联合小柴胡汤治疗。对比两组疗效、治疗7 d后溃疡愈合时间、激惹疼痛持续时间、中医症状积分变化及半年内复发情况。统计学方法采用t检验、χ²检验。结果　观察组治疗总有效率为88.3%（53/60），高于对照组的71.7%（43/60），差异有统计学意义（χ²=5.208，P=0.022）。观察组口腔溃疡激惹疼痛持续时间、溃疡愈合时间均短于对照组［（2.67±0.34）d比（4.55±0.61）d、（4.24±0.21）d比（7.68±0.87）d］，差异均有统计学意义（t=20.852、29.773，均P<0.05）。治疗7 d后，观察组中医症状积分差值为（5.66±0.82）分，低于对照组的（8.41±1.21）分，差异有统计学意义（t=14.573，P<0.001）。观察组患者治疗后6个月复发率为41.67%（25/60），低于对照组的80.00%（48/60），差异有统计学意义（χ²=18.502，P<0.001）。结论　小柴胡汤能有效治疗少阳失枢轻型ROU患者局部及全身症状，降低复发率。

关键词:

复发性口腔溃疡, 少阳失枢, 小柴胡汤, 临床观察