Relationship of serum levels of GDF-15 and PPARγ with coagulation indicators and prognosis in patients with early-onset preeclampsia

doi:10.3760/cma.j.issn.1007-1245.2024.23.022

Abstract

Abstract:

Objective　To explore the relationship of serum levels of growth differentiation factor 15 (GDF-15) and peroxisome proliferator-activated receptor γ (PPARγ) with coagulation indicators in patients with early-onset preeclampsia and their impact on prognosis. Methods　Seventy-six patients with early-onset preeclampsia treated at Ankang Maternal and Child Health Hospital from May 2020 to May 2023 were selected as a study group, and 75 healthy pregnant women during the same period a control group. The serum levels of GDF-15 and PPARγ were measured using the enzyme-linked immunosorbent assay. The coagulation function indicators [activated partial thromboplastin time (APTT), thrombin time (TT), prothrombin time (PT), and fibrinogen (FIB)] were detected. The patients were followed up for their prognosis. The correlation of the levels of GDF-15 and PPARγ with coagulation function was analyzed by the Pearson product coefficient. The predictive values of GDF-15, PPARγ, and coagulation indicators for the severity of preeclampsia were analyzed using the receiver operating characteristic curve (ROC). χ² and t tests were used for the statistical analysis. Results　The levels of GDF-15, PPARγ, and FIB in the severe group, the preeclampsia group, and the control group sequentially decreased, while the APTT, TT, and PT sequentially increased, with statistical differences (all P<0.05). The levels of GDF-15 and PPARγ were significantly correlated with coagulation indicators (all P<0.05). The area under the curve of the combination of these indicators was 0.779, with a sensitivity of 75.0% and a specificity of 80.0%. The levels of GDF-15 and PPARγ in the patients with good prognosis were lower than those in the patients with poor prognosis (both P<0.05). Conclusion　Serum levels of GDF-15 and PPARγ are elevated in patients with early-onset preeclampsia and are related to abnormal coagulation function, making them potential biomarkers for early diagnosis and prediction of adverse outcomes.

Key words:

Preeclampsia, Growth differentiation factor 15, Peroxisome proliferator-activated receptor γ, Coagulation indicators, Correlation

摘要：

目的　探讨早发型子痫前期患者血清生长分化因子15（growth differentiation factor 15，GDF-15）、过氧化物酶体增殖物激活受体γ（peroxisome proliferator-activated receptor gamma，PPARγ）水平与凝血指标之间的关系及其对预后的影响。方法　选取2020年5月至2023年5月安康市妇幼保健院收治的76例早发型子痫前期患者为研究组，另选取同期75例健康孕妇为对照组。采用酶联免疫吸附试验检测血清中GDF-15和PPARγ水平。检测两组凝血功能指标［部分活化凝血活酶时间（activated partial thromboplastin time，APTT）、凝血酶时间（thrombin time，TT）、凝血酶原时间（prothrombin time，PT）、纤维蛋白原（fibrinogen，FIB）］。对患者预后情况进行随访。GDF-15和PPARγ水平与凝血功能的关系采用Pearson积差系数进行相关性分析。采用受试者操作特征曲线（receiver operating characteristic curve，ROC）分析GDF-15、PPARγ及凝血指标对子痫前期严重程度的预测价值。采用χ²检验和t检验进行统计分析。结果　重度组、子痫前期组、对照组GDF-15、PPARγ、FIB水平依次降低，APTT、TT、PT依次升高，差异均有统计学意义（均P<0.05）。GDF-15、PPARγ水平与凝血指标均相关（均P<0.05）。几项指标联合检测的曲线下面积为0.779，灵敏度和特异度分别为75.0%和80.0%。预后良好组GDF-15、PPARγ水平低于预后不良组，差异均有统计学意义（均 P<0.05）。结论　早发型子痫前期患者血清中GDF-15和PPARγ水平升高，且与凝血功能异常相关，可以作为早期诊断和预测不良预后的生物标志物。

关键词:

子痫前期, 生长分化因子15, 过氧化物酶体增殖物激活受体γ, 凝血指标, 相关性

Tang Mingbo, Pan Yongheng, Lan Zhaoyang.

Relationship of serum levels of GDF-15 and PPARγ with coagulation indicators and prognosis in patients with early-onset preeclampsia [J]. International Medicine and Health Guidance News, 2024, 30(23): 3992-3996.

唐明波潘永恒兰朝阳.

早发型子痫前期患者血清GDF-15、PPARγ水平与凝血指标和预后的关系 [J]. 国际医药卫生导报, 2024, 30(23): 3992-3996.

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