Abstract:

Objective　To investigate the correlation between serum CC chemokine ligand 11 (CCL11) level and type 2 diabetes mellitus (T2DM) complicated with coronary atherosclerotic heart disease (CAD). Methods　A total of 146 T2DM patients admitted to Shangluo Central Hospital from January 2022 to April 2024 were selected and were divided into a CAD group (70 patients) and a T2DM group (76 patients) according to whether they were complicated with CAD or not. In the CAD group, there were 43 males and 27 females, aged (61.53±8.24) years. In the T2DM group, there were 42 males and 34 females, aged (59.30±6.86) years. The general clinical data of the two groups were collected, and the serum CCL11 level and related metabolic indicators were detected. t test and χ² test were used. Results　The duration of diabetes in the CAD group was longer than that in the T2DM group [(7.41±3.12) years vs. (6.08±2.58) years], and the levels of low density lipoprotein cholesterol (LDL-C) and serum CCL11 were higher than those in the T2DM group [(3.06±1.01) mmol/L vs. (2.60±0.78) mmol/L, (65.53±21.28) ng/L vs. (46.47±18.36) ng/L], with statistically significant differences (t=2.815, 3.094, and 5.807, all P<0.05). Binary logistic regression analysis showed that long duration of diabetes, high LDL-C and serum CCL11 levels were risk factors for CAD in T2DM patients (all P<0.05). The receiver operator characteristic curve (ROC) analysis showed that the area under the curve (AUC) of serum CCL11 level for diagnosing T2DM with CAD was 0.751, the sensitivity was 65.7%, the specificity was 78.9%, and the Youden index was 0.446. Conclusions　Long duration of diabetes, high LDL-C and serum CCL11 levels are independent risk factors for T2DM complicated with CAD. Serum CCL11 level has good diagnostic value in predicting T2DM complicated with CAD.

Key words:

Type 2 diabetes mellitus, Coronary atherosclerotic heart disease, CCL11, Correlation, Risk factors

摘要：

目的　探讨血清CC趋化因子配体11（CCL11）水平与2型糖尿病（T2DM）合并冠状动脉粥样硬化性心脏病（CAD）的相关性。方法　选取2022年1月至2024年4月商洛市中心医院收治的T2DM患者146例，按照是否合并CAD分为合并CAD组（CAD组）70例及单纯T2DM组（T2DM组）76例。CAD组中男43例，女27例，年龄（61.53±8.24）岁；T2DM组中男42例，女34例，年龄（59.30±6.86）岁。收集两组一般临床资料，检测血清CCL11水平及相关代谢指标。采用t检验、χ²检验。结果　CAD组T2DM病程长于T2DM组［（7.41±3.12）年比（6.08±2.58）年］，低密度脂蛋白胆固醇（LDL-C）和血清CCL11水平均高于T2DM组［（3.06±1.01）mmol/L比（2.60±0.78）mmol/L、（65.53±21.28）ng/L比（46.47±18.36）ng/L］，差异均有统计学意义（t=2.815、3.094、5.807，均P<0.05）。二元logistic回归分析结果显示，T2DM病程长、高LDL-C和血清CCL11水平均是T2DM合并CAD的危险因素（均P<0.05）。受试者操作特征曲线（ROC）分析显示，血清CCL11水平诊断T2DM合并CAD的曲线下面积（AUC）为0.751，灵敏度为65.7%，特异度为78.9%，约登指数为0.446。结论　T2DM病程长、高LDL-C和血清CCL11水平均是T2DM合并CAD的独立危险因素；血清CCL11水平对预测T2DM合并CAD具有较好的诊断价值。

关键词:

2型糖尿病, 冠状动脉粥样硬化性心脏病, CCL11, 相关性, 危险因素