Abstract:

Objective　To evaluate the efficacy and safety of aloe and Lianchuang Shenji ointment for nasopharyngeal carcinoma patients with radiation dermatitis. Methods　Ninety-six nasopharyngeal carcinoma patients with radiation dermatitis treated at Department of Radiotherapy, Yulin Hospital, First Hospital, Xi'an Jiaotong University from January 2020 to May 2023 were selected for the randomized controlled trial, and were divided into a control group and a study group by the random number table method, with 48 cases in each group. There were 23 males and 25 females in the control group; they were (52.84±9.41) years old. There were 26 males and 22 females in the study group; they were (53.66±8.57) years old. The control group took routine treatment. The study group were treated with aloe and Lianchuang Shenji ointment. The radiation dermatitis grades (RTOG), treatment effects, scores of acute radiation dermatitis response (RISRAS), pain scores of Numerical Rating Scale (NRS), scores of Karnofsky Performance Status (KPS), and serum levels of interleukin-6 (IL-6) and C-reaction protein (CRP), before and after the treatment and incidences of adverse reactions were compared between the two groups by t and χ² tests. Results　The total effective rate in the study group was higher than that in the control group [93.8% (45/48) vs. 72.9% (35/48)], with a statistical difference (χ²=5.423; P=0.009). Before the treatment, there were no statistical differences in the radiation dermatitis grade, scores of RISRAS, NRS, and KPS, and levels of IL-6 and CRP between the two groups (all P>0.05). After the treatment, the proportion of the patients with > radiation dermatitis grade Ⅰ, scores of RISRAS and NRS, and levels of IL-6 and CRP in the study group were lower than those in the control group [20.8% (10/48) vs. 45.8% (22/48), (3.22±1.65) vs. (6.17±1.97), (0.47±0.21) vs. (1.11±0.62), (26.13±4.71) μg/L vs. (34.17±5.62) μg/L, and (7.22±1.91) mg/L vs. (10.75±2.13) mg/L]; the score of KPS in the study group was higher than that in the control group [(85.11±12.45) vs. (72.21±11.54)]; there were statistical differences (all P<0.05). No significant adverse reactions were observed in either group. Conclusion　Aloe combined with Lianchuang Shenji ointment for nasopharyngeal carcinoma patients with radiation dermatitis is an effective and safe method, providing a new option for clinical treatment.

Key words:

Nasopharyngeal carcinoma, Aloe, Lianchuang Shenji ointment, Radiation dermatitis, Clinical study

摘要：

目的　分析芦荟和敛疮生肌膏在治疗鼻咽癌放射性皮炎患者中的效果及安全性。方法　选取2020年1月至2023年5月在西安交通大学第一附属医院榆林医院肿瘤放疗科就诊的96例鼻咽癌放射性皮炎患者进行随机对照试验，采用随机数字表法分为两组，各48例。对照组男23例、女25例，年龄（52.84±9.41）岁，接受常规治疗；研究组男26例、女22例，年龄（53.66±8.57）岁，采用芦荟联合敛疮生肌膏治疗。对比两组患者治疗前后放射性皮炎分级情况［根据放射治疗肿瘤学组（RTOG）标准评估］、治疗效果、急性放射性皮炎反应评估量表（RISRAS）、疼痛程度数字评估量表（NRS）、卡氏功能状态（KPS）评分、白细胞介素6（IL-6）、C-反应蛋白（CRP）水平及不良反应发生情况。统计学方法采用t检验、χ²检验。结果　研究组总有效率为93.8%（45/48），高于对照组的72.9%（35/48），差异有统计学意义（χ²=5.423，P=0.009）。治疗前，两组患者放射性皮炎分级情况、RISRAS、NRS、KPS评分及IL-6、CRP水平比较，差异均无统计学意义（均P>0.05）。治疗后，研究组放射性皮炎>Ⅰ级患者占比、RISRAS、NRS评分及IL-6、CRP水平均低于对照组［20.8%（10/48）比45.8%（22/48）、（3.22±1.65）分比（6.17±1.97）分、（0.47±0.21）分比（1.11±0.62）分、（26.13±4.71）μg/L比（34.17±5.62）μg/L、（7.22±1.91）mg/L比（10.75±2.13）mg/L］，KPS评分高于对照组［（85.11±12.45）分比（72.21±11.54）分］，差异均有统计学意义（均P<0.05）。两组患者均未发现明显不良反应情况。结论　芦荟联合敛疮生肌膏治疗鼻咽癌放射性皮炎是一种有效且安全的方法，为临床治疗提供了新的选择。

关键词:

鼻咽癌, 芦荟, 敛疮生肌膏, 放射性皮炎, 临床研究