Abstract:

Objective　To analyze the relationship between serum uric acid (SUA) and carotid intima-media thickness (CIMT) in patients with hypertension. Methods　A retrospective study was conducted to select 110 patients diagnosed with hypertension in Xi'an Hospital of Traditional Chinese Medicine from March to October 2020. Among them, there were 60 patients with simple hypertension [HT group, 31 males and 29 females, aged (51.59±10.84) years] and 50 patients with hypertension combined with hyperuricemia [HT+HU group, 23 males and 27 females, aged (52.27±10.12) years]. In addition, 40 healthy adults were selected [healthy control group, 20 males and 20 females, aged (51.23±9.43) years]. The differences of blood pressure, body mass index (BMI), triglyceride, total cholesterol, high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), SUA, and CIMT among all the groups were compared, and the correlation between SUA and CIMT was analyzed. The statistical methods were one-way ANOVA, χ² test, partial correlation analysis, and multiple linear regression analysis. Results　There were no statistically significant differences in the gender, age, heart rate, smoking, total cholesterol, triglyceride, HDL-C, and LDL-C among the 3 groups (all P>0.05). The SUA level in the HU+HT group was higher than that in the control group and the HT group [(496.52±74.82) μmol/L vs. (253.42±80.46) μmol/L vs. (267.78±75.72) μmol/L], with a statistically significant difference (F=156.14, P<0.05). The systolic blood pressure and diastolic blood pressure in the HT group and the HU+HT group were higher than those in the control group [(164.72±12.86) mmHg (1 mmHg=0.133 kPa) vs. (165.87±12.96) mmHg vs. (106.75±7.46) mmHg, (98.82±6.56) mmHg vs. (98.78±6.85) mmHg vs. (73.68±4.66) mmHg], with statistically significant differences (F=366.07 and 239.34, both P<0.05). The CIMT of the HU+HT group and the HT group were higher than that of the control group, and the CIMT of the HU+HT group was higher than those of the HT group and the control group [(1.02±0.18) mm vs.(0.85±0.19) mm vs. (0.60±0.11) mm], with a statistically significant difference (F=68.95, P<0.05). Partial correlation analysis showed that SUA level was positively correlated with CIMT level in the HU+HT group (r=0.42, P<0.05). Multiple linear regression analysis showed that SUA level was an independent risk factor for CIMT in hypertensive patients (P<0.05). Conclusions　The thickening of CIMT is significant in patients with hypertension combined with hyperuricemia, and the SUA level in patients with hypertension is closely related to CIMT. When patients with hypertension are combined with hyperuricemia, the course of cardiovascular diseases such as atherosclerosis is further aggravated.

Key words:

Hypertension, Hyperuricemia, Serum uric acid, Carotid intima-media thickness, Atherosclerosis, Cardiovascular diseases

摘要：

目的　探讨高血压患者血尿酸（SUA）水平与颈动脉内-中膜厚度（CIMT）的相关性。方法　采用回顾性研究，选取西安市中医医院2020年3月至10月被诊断为高血压的患者110例。其中，单纯高血压患者60例［HT组，男31例，女29例，年龄（51.59±10.84）岁］，高血压合并高尿酸血症者50例［HT+HU组，男23例，女27例，年龄（52.27±10.12）岁］。另外，选取健康体检者40名［健康对照组，男20例，女20例，年龄（51.23±9.43）岁］。比较各组之间的血压、体重指数（BMI）、甘油三酯、总胆固醇、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、SUA、CIMT的差异，分析SUA水平与CIMT的相关性。统计学方法采用单因素方差分析、χ²检验、偏相关分析、多元线性回归分析。结果　3组之间性别、年龄、心率、吸烟、总胆固醇、甘油三酯、HDL-C、LDL-C比较，差异均无统计学意义（均P>0.05）；HU+HT组SUA水平高于对照组与HT组［（496.52±74.82）μmol/L比（253.42±80.46）μmol/L比（267.78±75.72）μmol/L］，差异有统计学意义（F=156.14，P<0.05）；HT组与HU+HT组的收缩压、舒张压均高于对照组［（164.72±12.86）mmHg（1 mmHg=0.133 kPa）比（165.87±12.96）mmHg比（106.75±7.46）mmHg、（98.82±6.56）mmHg比（98.78±6.85）mmHg比（73.68±4.66）mmHg］，差异均有统计学意义（F=366.07、239.34，均P<0.05）；HU+HT组与HT组的CIMT均高于对照组，HU+HT组高于HT组与对照组［（1.02±0.18）mm比（0.85±0.19）mm比（0.60±0.11）mm］，差异有统计学意义（F=68.95，P<0.05）。偏相关分析显示，HU+HT组患者的SUA水平与CIMT水平正相关（r=0.42，P<0.05）。多因素线性回归分析显示，SUA水平是高血压患者CIMT的独立影响因素（P<0.05）。结论　高血压合并高尿酸血症患者的CIMT增厚显著，高血压患者SUA水平与CIMT密切相关，当高血压患者合并高尿酸血症时，进一步加重了动脉粥样硬化等心血管疾病的进程。

关键词:

高血压, 高尿酸血症, 血尿酸, 颈动脉内-中膜厚度, 动脉粥样硬化, 心血管疾病