Abstract:

Objective　To analyze the clinical value of immunomagnetic bead separation technology in the detection of vaginitis caused by Candida albicans. Methods　One hundred and ninety women who were took vaginal secretion examination at Zhengzhou People's Hospital from June 2021 to January 2023 were selected as the study objects; 102 patients with candida albicans vaginitis were included into the case group, and the rest 88 healthy volunteers who underwent routine gynecological examination were included into the control group. The vaginal secretions were detected by the wet film microscopy and immunomagnetic bead separation technology; the results of vaginal secretion culture were set as the gold standard. The detection and diagnostic efficacies of the two techniques were compared. χ² test was applied. Results　The detection rate of vaginitis caused by Candida albicans, diagnostic accuracy, sensitivity, and specificity by the immunomagnetic bead separation technology were higher than those by the wet film microscopy [86.27% (88/102) vs. 68.63% (70/102), 95.26% (181/190) vs. 81.58% (155/190), 86.27% (88/102) vs. 68.63% (70/102), and 94.32% (83/88) vs. 85.23% (75/88); χ²=8.908, 9.139, 8.908, and 4.501; P=0.003, 0.003, 0.003, and 0.034]. Conclusion　Immunomagnetic bead separation technology can effectively detect the infection type of vaginitis patients, and is of great significance in improving the diagnostic accuracy of vaginitis caused by Candida albicans and guiding clinical treatment.

Key words:

Candida albicans, Vaginitis, Wet film microscopy, Immunomagnetic bead separation technology, Detection value

摘要：

目的　分析免疫磁珠分离技术对白色念珠菌所致阴道炎的临床检测价值。方法　选取2021年6月至2023年1月于郑州人民医院接受阴道分泌物检查的190名女性作为研究对象，将102例白色念珠菌阴道炎患者列为病例组，其余88例行常规妇科检查的健康志愿者列为对照组。以阴道分泌物培养结果为金标准，采用湿片镜检法及免疫磁珠分离技术检测研究对象阴道分泌物，比较不同检测技术的检出情况及诊断效能。采用χ²检验。结果　免疫磁珠分离技术对于白色念珠菌所致阴道炎的检出率、诊断准确率、灵敏度、特异度均高于湿片镜检法［86.27%（88/102）比68.63%（70/102）、95.26%（181/190）比81.58%（155/190）、86.27%（88/102）比68.63%（70/102）、94.32%（83/88）比85.23%（75/88）；χ²=8.908、9.139、8.908、4.501，P=0.003、0.003、0.003、0.034］。结论　免疫磁珠分离技术可有效检测阴道炎患者感染类型，对提升白色念珠菌所致阴道炎的诊断准确率和指导临床治疗均有重要意义。

关键词:

白色念珠菌, 阴道炎, 湿片镜检法, 免疫磁珠分离技术, 检测价值