Abstract:

Objective　To investigate the correlation between serum levels of myelin basic protein (MBP), glyoxalase Ⅰ (GLOⅠ), and high-sensitivity-C-reactive protein (hs-CRP) and diabetic peripheral neuropathy (DPN). Methods　From July to December 2021, 30 patients with DPN treated at Guangzhou General Hospital, Foresea Life Insurance were selected as an observation group A [9 males and 21 females; (60.46±11.65) years old; their body mass index was (24.50±1.68) kg/m²], 30 patients with diabetes mellitus (DM) but no peripheral neuropathy as an observation group B [8 males and 22 females; (54.12±10.47) years old; their body mass index was (24.66±1.72) kg/m²], and 30 healthy persons taking physical examination as a control group [11 males and 19 females; (56.54±7.26) years old; their body mass index was (25.01±1.86) kg/m²]. The serum levels of MBP, GLOⅠ, and hs-CRP in all the subjects were detected. The serum levels of MBP, GLOⅠ, and hs-CRP in the three groups were compared by one way analysis of variance. The correlation between the serum levels of MBP, GLOⅠ, and hs-CRP and DPN was analyzed by Pearson correlation. Results　The levels of MBP and hs-CRP in the observation group A were higher than those in the observation group B and the control group, and the level of GLOⅠ was lower than those in the observation B and the control group (all P<0.05); the levels of MBP and hs-CRP in the observation group B were higher than those in the control group, and the level of GLOⅠ were lower than that in the control group (all P<0.05). Pearson correlation analysis showed that the serum MBP and hs-CRP levels were positively correlated with DPN (r=0.297 and 0.615, both P<0.05), and the serum GLOⅠ level was negatively correlated with DPN (r=-0.501, P<0.05). Conclusions　High levels of MBP and hs-CRP and low GLOⅠ level are associated with the occurrence of DPN. The detection of serum levels of MBP, GLOⅠ, and hs-CRP is helpful in diagnosing DPN.

Key words:

Diabetic peripheral neuropathy, Glyoxalase Ⅰ, Serum myelin basic protein, High-sensitivity-C-reactive protein

摘要：

目的　探讨血清髓鞘碱性蛋白（MBP）、乙二醛酶Ⅰ（GLOⅠ）、高敏-C反应蛋白（hs-CRP）水平与糖尿病周围神经病变（DPN）的相关性。方法　选取前海人寿广州总医院2021年7月至12月收治的DPN患者30例作为观察A组［男9例，女21例，年龄（60.46±11.65）岁，体质量指数（24.50±1.68）kg/m²］，无周围神经病变的糖尿病（DM）30例［男8例，女22例，年龄（54.12±10.47）岁，体质量指数（24.66±1.72）kg/m²］作为观察B组，同时选取同期健康体检者30例作为对照组［男11例，女19例，年龄（56.54±7.26）岁，体质量指数（25.01±1.86）kg/m²］。所有研究对象均检测血清MBP、GLOⅠ、hs-CRP水平，采用单因素方差分析比较3组研究对象血清MBP、GLOⅠ、hs-CRP水平，采用Pearson相关性分析血清MBP、GLOⅠ、hs-CRP水平与DPN的相关性。结果　观察A组MBP、hs-CRP水平高于观察B组、对照组，GLOⅠ水平低于观察B组、对照组（均P<0.05）；观察B组MBP、hs-CRP水平高于对照组，GLOⅠ水平低于对照组（均P<0.05）。Pearson相关性分析显示，血清MBP、hs-CRP水平与DPN呈正相关（r=0.297、0.615，均P<0.05），血清GLOⅠ水平与DPN呈负相关（r=-0.501，P<0.05）。结论　高MBP、hs-CRP水平、低GLOⅠ水平与DPN发生有关，检测血清MBP、GLOⅠ、hs-CRP水平有助于诊断DPN。

关键词:

糖尿病周围神经病变, 乙二醛酶Ⅰ, 髓鞘碱性蛋白, 高敏C反应蛋白