Research advances in glucocorticoid-induced apoptosis

doi:10.3760/cma.j.issn.1007-1245.2022.20.005

Abstract

Abstract: Apoptosis is vital in the entire growth process from embryo to biosome, which is conducive to tissue renewal and elimination of inflammatory cells. Glucocorticoids have the effects of promoting apoptosis and anti-apoptosis in different tissues and cells. Although the research progress of its induced apoptosis has made great advance in recent years, the concrete mechanism isn't still clarity. This paper emphatically introduces the mechanism of promoting apoptosis of glucocorticoids, and points out its main research content in the molecular biology in each system.

Key words: Apoptosis, Glucocorticoids, Signal pathways, Mechanism

摘要： 细胞凋亡从胚胎发育到生物体的整个生长过程中都是至关重要的，有助于组织的更新以及消除炎症细胞。糖皮质激素在不同组织细胞中表现出促凋亡和抗凋亡作用。虽然近几年其诱导凋亡研究进展得到长足的发展，但是详细机制过程至今仍旧不清楚。本文将重点介绍糖皮质激素促进细胞凋亡的机制，并指出了其在各个系统中分子生物学的主要研究进展。

关键词: 凋亡, 糖皮质激素, 信号通路, 机制

Xiang Xiaohong, Hu Jingwei. Research advances in glucocorticoid-induced apoptosis[J]. International Medicine and Health Guidance News, 2022, 28(20): 2839-2843.

项晓洪胡景伟. 糖皮质激素诱导细胞凋亡的研究进展[J]. 国际医药卫生导报, 2022, 28(20): 2839-2843.

References

[1] 刘义粉, 张九菊. 产前皮质激素接触对子代青春期大鼠甲状腺形态功能的影响[J]. 中国免疫学杂志, 2020, 36(23): 2828-2831. DOI: 10.3969/j.issn.1000-484X.2020.23.003.
[2] He J, Zhou J, Yang W, et al. Dexamethasone affects cell growth/apoptosis/chemosensitivity of colon cancer via glucocorticoid receptor α/NF-κB[J]. Oncotarget, 2017, 8(40): 67670-67683. DOI: 10.18632/oncotarget.18802.
[3] Clarisse D, Offner F, De Bosscher K. Latest perspectives on glucocorticoid-induced apoptosis and resistance in lymphoid malignancies[J]. Biochim Biophys Acta Rev Cancer, 2020, 1874(2): 188430. DOI: 10.1016/j.bbcan.2020.188430.
[4] 程晓刚,粟永萍,罗成基. 糖皮质激素与细胞凋亡的研究进展[J]. 免疫学杂志,2003,19(6):474-477. DOI:10.3969/j.issn.1000-8861.2003.06.019.
[5] Salvesen GS, Ashkenazi A. Snapshot: caspases[J]. Cell,2011,147(2):476,e1. DOI: 10.1016/j.cell.2011.09.030.
[6] Beyer K, Baukloh AK, Stoyanova A, et al. Interactions of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) with the immune system: implications for inflammation and cancer[J]. Cancers (Basel), 2019,11(8):1161. DOI: 10.3390/cancers11081161.
[7] Wu Y, Li X, Jia J, et al. Transmembrane E3 ligase RNF183 mediates ER stress-induced apoptosis by degrading Bcl-xL[J]. Proc Natl Acad Sci U S A, 2018,115(12):E2762-E2771. DOI:10.1073/pnas.1716439115.
[8] Bhardwaj M, Leli NM, Koumenis C, et al. Regulation of autophagy by canonical and non-canonical ER stress responses[J]. Semin Cancer Biol, 2020, 66: 116-128. DOI: 10.1016/j.semcancer.2019.11.007.
[9] Gao Y, Zhu H, Wang Q, et al. Inhibition of PERK signaling prevents against glucocorticoid-induced endotheliocyte apoptosis and osteonecrosis of the femoral head[J]. Int J Biol Sci, 2020,16(4): 543-552. DOI:10.7150/ijbs.35256.
[10] Gao Y, Zhu H, Yang F, et al. Glucocorticoid-activated IRE1α/XBP-1s signaling: an autophagy-associated protective pathway against endotheliocyte damage[J]. Am J Physiol Cell Physiol, 2018, 315(3): C300-C309. DOI: 10.1152/ajpcell.00009.2018.
[11] Zuo W, Guo WS, Yu HC, et al. Role of junction-mediating and regulatory protein in the pathogenesis of glucocorticoid-induced endothelial cell lesions[J]. Orthop Surg, 2020,12(3):964-973. DOI:10.1111/os.12680.
[12] Price LC, Shao D, Meng C, et al. Dexamethasone induces apoptosis in pulmonary arterial smooth muscle cells[J]. Respir Res, 2015,16(1):114. DOI:10.1186/s12931-015-0262-y.
[13] Zhang B, Zhang G, Wei T, et al. MicroRNA-25 protects smooth muscle cells against corticosterone-induced apoptosis[J]. Oxid Med Cell Longev, 2019, 2019: 2691514. DOI: 10.1155/2019/2691514.
[14] Du J, Wang Y, Hunter R, et al. Dynamic regulation of mitochondrial function by glucocorticoids[J].Proc Natl Acad Sci U S A, 2009, 106(9): 3543-3548. DOI: 10.1073/pnas.0812671106.
[15] Zhang B, Xu X, Niu F, et al. Corticosterone replacement alleviates hippocampal neuronal apoptosis and spatial memory impairment induced by dexamethasone via promoting brain corticosteroid receptor rebalance after traumatic brain injury[J]. J Neurotrauma, 2020, 37(2): 262-272. DOI: 10.1089/neu.2019.6556.
[16] Zhang B, Bai M, Xu X, et al. Corticosteroid receptor rebalancing alleviates critical illness-related corticosteroid insufficiency after traumatic brain injury by promoting paraventricular nuclear cell survival via Akt/CREB/BDNF signaling[J]. J Neuroinflammation, 2020, 17(1): 318. DOI:10.1186/s12974-020-02000-2.
[17] Wu CH, Chen CC, Hung TH, et al. Activation of TrkB/Akt signaling by a TrkB receptor agonist improves long-term histological and functional outcomes in experimental intracerebral hemorrhage[J]. J Biomed Sci, 2019, 26(1): 53. DOI:10.1186/s12929-019-0543-8.
[18] Yi S, Shi W, Zuo M, et al. Endoplasmic reticulum stress is involved in glucocorticoid-induced apoptosis in PC12 cells[J]. Anal Cell Pathol (Amst), 2021, 2021: 5565671. DOI: 10.1155/2021/5565671.
[19] Gu R, Tang W, Lei B, et al. Synthesized glucocorticoid-induced leucine zipper peptide inhibits photoreceptor apoptosis and protects retinal function in light-induced retinal degeneration model[J]. lin Exp Ophthalmol, 2019, 7(5): 46-657. DOI: 0.1111/ceo.13452.
[20] Peng P, Nie Z, Sun F, et al, Glucocorticoids induce femoral head necrosis in rats through the ROS/JNK/c-Jun pathway[J]. FEBS Open Bio, 2021, 11(1): 312-321. DOI: 10.1002/2211-5463.13037.
[21] Plotkin LI, Manolagas SC, Bellido T. Glucocorticoids induce osteocyte apoptosis by blocking focal adhesion kinase-mediated survival. Evidence for inside-out signaling leading to anoikis[J]. J Biol Chem, 2007, 282(33): 24120-24130. DOI: 10.1074/jbc.M611435200.
[22] Wang T, Liu X, He C. Glucocorticoid-induced autophagy and apoptosis in bone[J]. Apoptosis, 2020, 25(3-4): 157-168. DOI: 10.1007/s10495-020-01599-0.
[23] Almeida M, Han L, Ambrogini E, et al. Glucocorticoids and tumor necrosis factor α increase oxidative stress and suppress Wnt protein signaling in osteoblasts[J]. J Biol Chem, 2011, 286(52): 44326-44335. DOI: 10.1074/jbc.M111.283481.
[24] Guo Y, Hao D, Hu H. High doses of dexamethasone induce endoplasmic reticulum stress-mediated apoptosis by promoting calcium ion influx-dependent CHOP expression in osteoblasts[J]. Mol Biol Rep, 2021, 48(12): 7841-7851. DOI: 10.1007/s11033-021-06806-y.
[25] Hu H, Tian M, Ding C, et al. The C/EBP homologous protein (CHOP) transcription factor functions in endoplasmic reticulum stress-induced apoptosis and microbial infection[J]. Front Immunol, 2019, 9: 3083. DOI: 10.3389/fimmu.2018.03083.
[26] Cheng S, Liu X, Gong F, et al. Dexamethasone promotes the endoplasmic reticulum stress response of bone marrow mesenchymal stem cells by activating the PERK-Nrf2 signaling pathway[J]. Pharmacol Res Perspect, 2021, 9(3): e00791. DOI: 10.1002/prp2.791.
[27] Suksri K, Semprasert N, Junking M, et al. Dexamethasone induces pancreatic β-cell apoptosis through upregulation of TRAIL death receptor[J].J Mol Endocrinol, 2021, 67(3): 95-106. DOI: 10.1530/JME-20-0238.
[28] Teixeira CJ, Santos-Silva JC, de Souza DN, et al. Dexamethasone during pregnancy impairs maternal pancreatic β-cell renewal during lactation[J]. Endocr Connect, 2019, 8(2): 120-131. DOI: 10.1530/EC-18-0505.
[29] Yuan HJ, Li ZB, Zhao XY, et al. Glucocorticoids impair oocyte competence and trigger apoptosis of ovarian cells via activating the TNF-α system[J]. Reproduction, 2020, 160(1): 129-140. DOI: 10.1530/REP-20-0025.
[30] Zheng LL, Tan XW, Cui XZ, et al. Preimplantation maternal stress impairs embryo development by inducing oviductal apoptosis with activation of the Fas system[J]. Mol Hum Reprod, 2016, 22(11): 778-790. DOI:10.1093/molehr/gaw052.
[32] Ronchetti S, Ricci E, Migliorati G, et al. How glucocorticoids affect the neutrophil life[J]. Int J Mol Sci, 2018, 19(12): 4090. DOI:10.3390/ijms19124090.
[33] Prenek L, Litvai T, Balázs N, et al. Regulatory T cells are less sensitive to glucocorticoid hormone induced apoptosis than CD4+ T cells[J]. Apoptosis, 2020, 25(9-10): 715-729. DOI:10.1007/s10495-020-01629-x.
[34] Yao J, Leng L, Fu W, et al. ICBP90 regulates MIF expression, glucocorticoid sensitivity, and apoptosis at the MIF immune susceptibility locus[J]. Arthritis Rheumatol, 2021, 73(10): 1931-1942. DOI: 10.1002/art.41753.