Tet in regulation of Th17/Treg cell differentiation and in
participatesion of pathogenesis of autoimmune diseases

doi:10.3760/cma.j.issn.1007-1245.2022.11.005

International Medicine and Health Guidance News ›› 2022, Vol. 28 ›› Issue (11): 1500-1504.DOI: 10.3760/cma.j.issn.1007-1245.2022.11.005

• Scientific Research • Previous Articles Next Articles

Tet in regulation of Th17/Treg cell differentiation and in participatesion of pathogenesis of autoimmune diseases

Jiang Guantong¹, Zhou Jin², Xue Haibo¹

¹Department of Endocrinology, Binzhou Medical University Hospital, Binzhou 256603, China;
²Department of Endocrinology, Yantai Yuhuangding Hospital, Yantai 264000, China

Received:2022-01-17 Online:2022-06-01 Published:2022-06-15
Contact: Xue Haibo, Email: xuehaibo@sina.com
Supported by:
Innovation Program of Post-graduate Education in Shandong Province (20038612);

Scientific Research and Innovation Team Project of Binzhou Medical University Hospital (202031);

Project for Reserved Leading Talents of Binzhou Medical University Hospital (JC2019-03)

Tet调控Th17/Treg细胞分化参与自身免疫性疾病发病的研究进展

姜冠桐¹ 周瑾² 薛海波¹

¹滨州医学院附属医院内分泌科，滨州　256603； ²烟台毓璜顶医院内分泌科，烟台　264000

通讯作者: 薛海波，Email：xuehaibo@sina.com
基金资助:
山东省研究生教育创新计划项目（20038612）；

滨州医学院附属医院科研创新团队（202031）；

滨州医学院附属医院后备领军人才（JC2019-03）

Abstract

Abstract: CD4⁺ T cells are an important part of human immunity. T helper cell 17 (Th17) and regulatory T cells (Treg), two newly discovered subsets of CD4⁺ T cells, play a key role in the occurrence and development of autoimmune diseases. Th17 cause autoimmunity and inflammation, while Treg inhibit the emergence of diseases and maintain immune homeostasis. Ten-eleven translocation (Tet), as a key factor in DNA demethylation, affects the Th17/Treg balance and involves in the progression of autoimmune diseases when it is absent. This review focuses on the research of the regulatory role of Tet on Th17/Treg cell immunization balance and the possible pathogenesis of autoimmune diseases.

Key words: Tet, Th17, Treg, Th17/Treg, Autoimmune diseases

摘要： CD4⁺T细胞是人体免疫重要的一部分，其中辅助性T细胞17（T helper cell 17，Th17）和调节性T细胞（regulatory T cells，Treg）两个新近发现的CD4⁺T细胞亚群在自身免疫疾病的发生发展中也起关键作用。Th17细胞能够引起自身免疫和炎性反应，而Treg细胞抑制疾病发生并维持免疫稳态；10～11易位蛋白（ten-eleven translocation，Tet）作为DNA去甲基化的关键因子，当其缺失时能够影响Th17/Treg免疫平衡。本文针对Tet调控Th17/Treg细胞分化参与自身免疫疾病发生发展的研究进展作一综述。

关键词: Tet, Th17, Treg, Th17/Treg, 自身免疫性疾病

Jiang Guantong, Zhou Jin, Xue Haibo. Tet in regulation of Th17/Treg cell differentiation and in participatesion of pathogenesis of autoimmune diseases[J]. International Medicine and Health Guidance News, 2022, 28(11): 1500-1504.

姜冠桐, 周瑾, 薛海波. Tet调控Th17/Treg细胞分化参与自身免疫性疾病发病的研究进展[J]. 国际医药卫生导报, 2022, 28(11): 1500-1504.

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Tet in regulation of Th17/Treg cell differentiation and in participatesion of pathogenesis of autoimmune diseases

Tet调控Th17/Treg细胞分化参与自身免疫性疾病发病的研究进展

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