Abstract:

Malignant tumors of the external genitalia are rare, with squamous cell carcinoma being the main pathological type, which mostly occur in middle-aged and elderly women before and after menopause. In recent years, there has been a trend towards younger age at onset of vulvar cancer in young women, most of which is related to persistent infection with high-risk human papillomavirus (HPV), especially HPV16. Systemic lupus erythematosus (SLE) is a group of autoimmune diseases that are closely related to HPV infection and the development of female genital tract tumors. Due to limited clinical samples and insufficient research evidences, it is difficult to determine the correlation between vulvar cancer and SLE. This article reports a case of vulvar cancer complicated with SLE, describes its clinical diagnosis and treatment process in detail, summarizes experiences, and further explores their correlation based on the latest literature review for discussion and learning among clinical physicians as well as providing reference for diagnosis, treatment, and prevention of vulvar cancer complicated with SLE.

Key words:

Vulvar cancer, Systemic lupus erythematosus, Human papillomavirus

摘要：

外阴恶性肿瘤较少见，病理类型主要为鳞癌，大多发生于绝经前后的中老年女性。近年，外阴癌发病年龄有年轻化趋势，年轻女性外阴癌发病大多与高危型人乳头瘤病毒（HPV）持续感染有关，尤其是HPV16型。系统性红斑狼疮（SLE）为自身免疫系统疾病，与HPV感染及女性生殖道肿瘤发生发展关系密切。由于临床样本量小，相关研究证据不足，外阴癌与SLE相关性较难明确。本文报道1例外阴癌合并SLE患者，详细描述患者临床诊断和治疗过程，分析总结经验，结合文献探讨两者相关性，为外阴癌合并SLE诊疗及预防提供参考。

关键词:

外阴癌, 系统性红斑狼疮, 人乳头瘤病毒