Role and regulatory mechanism of mitochondrial dynamics in diabetic nephropathy

doi:10.3760/cma.j.cn441417-20240722-02002

Abstract

Abstract:

Diabetic nephropathy (DN) is a progressive microvascular complication of diabetes. It is the main cause of kidney failure and death in diabetic patients. The balance between mitochondrial division and fusion is essential for maintaining cell homeostasis and mitochondrial health. In DN, the imbalance of mitochondrial dynamics caused by the imbalance of mitochondrial fission and fusion is the core pathological process. In this paper, we review the role and regulatory mechanism of mitochondrial dynamics in DN and the relevant targeted drugs targeting mitochondrial dynamics, so as to provide ideas for the future clinical treatment of DN.

Key words:

Diabetic nephropathy, Mitochondrial dynamics, Mitochondrial fission, Mitochondrial fusion, Progress

摘要：

糖尿病肾病（diabetic nephropathy，DN）是一种进展性糖尿病微血管并发症，是糖尿病患者肾衰竭和死亡的主要原因。线粒体裂变与融合过程的平衡对维持线粒体健康和细胞稳态很重要。在DN中，线粒体裂变与融合的不平衡导致的线粒体动力学失衡是核心病理过程。本文就线粒体动力学在DN中的作用、调节机制及针对线粒体动力学的相关靶向药物进行综述，为未来DN的临床治疗提供思路。

关键词:

糖尿病肾病, 线粒体动力学, 线粒体裂变, 线粒体融合, 进展

Xing Wenhua, Liang Dong, Liu Jie, Li Mengjie, Zhang Xiaomin.

Role and regulatory mechanism of mitochondrial dynamics in diabetic nephropathy [J]. International Medicine and Health Guidance News, 2025, 31(2): 183-187.

邢文华梁栋刘洁李梦洁张晓敏.

线粒体动力学在糖尿病肾病中的作用及调节机制 [J]. 国际医药卫生导报, 2025, 31(2): 183-187.

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