ASL技术在SNHL患者脑血流灌注评估中的研究进展

doi:10.3760/cma.j.cn441417-20250310-18002

国际医药卫生导报 ›› 2025, Vol. 31 ›› Issue (18): 2999-3003.DOI: 10.3760/cma.j.cn441417-20250310-18002

ASL技术在SNHL患者脑血流灌注评估中的研究进展

衣泳洁¹ 黄冉冉² 王爱杰² 黄翘路¹ 李朝蕙¹ 姜兴岳¹ 张国伟²

¹滨州医学院医学影像学院，烟台 264003；²滨州医学院附属烟台山医院影像科，烟台 264003

收稿日期:2025-03-10 出版日期:2025-09-15 发布日期:2025-09-25
通讯作者: 张国伟，Email：ytszgw@163.com
基金资助:
山东省医药卫生科技项目（202409040614）

Research progress of ASL in assessment of cerebral blood flow perfusion in patients with sensorineural hearing loss

Yi Yongjie¹, Huang Ranran², Wang Aijie², Huang Qiaolu¹, Li Chaohui¹, Jiang Xingyue¹, Zhang Guowei²

¹School of Medical Imaging, Binzhou Medical University, Yantai 264003, China; ²Department of Imaging, Yantaishan Hospital, Binzhou Medical University, Yantai 264003, China

Received:2025-03-10 Online:2025-09-15 Published:2025-09-25
Contact: Zhang Guowei, Email: ytszgw@163.com
Supported by:
Project of Medical and Health Science and Technology in Shandong Province (202409040614)

摘要/Abstract

摘要：

感音神经性耳聋（sensorineural hearing loss，SNHL）是由内耳感觉毛细胞代谢异常、供血不足、炎症反应等原因导致的听力障碍，严重影响患者的身心健康和工作生活。动脉自旋标记（arterial spin labeling，ASL）作为一种无需使用对比剂的磁共振检查技术，可以在无辐射、无对比剂的情况下，客观反映脑血流灌注和脑血流储备量，在SNHL患者脑血流灌注评估中具有重要价值。ASL技术不仅可以精准定位与SNHL相关功能脑区血流灌注情况，还能动态监测患者治疗前后的脑血流灌注变化，正逐步成为研究SNHL脑血流相关病理生理机制的重要工具。基于此，本文对ASL技术在SNHL患者脑血流灌注评估研究中的新进展进行归纳总结，探讨SNHL患者发生脑血流改变的机制，为临床诊疗和实验室研究提供参考。

关键词:

动脉自旋标记, 感音神经性耳聋, 血流灌注, 磁共振成像, 进展

Abstract:

Sensorineural hearing loss (SNHL) is a type of hearing impairment caused by metabolic abnormalities of the sensory hair cells in the inner ear, insufficient blood supply, inflammatory reactions, and other factors. It severely affects the patients' physical and mental health, as well as their work and daily life. Arterial spin labeling (ASL), as a contrast-free magnetic resonance imaging technique, can objectively reflect cerebral blood flow perfusion and cerebral blood flow reserve without radiation or contrast agents. It holds significant value in the assessment of cerebral blood flow perfusion in patients with SNHL. ASL can not only precisely locate the blood flow perfusion in brain regions related to SNHL, but also dynamically monitor changes in cerebral blood flow perfusion before and after treatment. It is gradually becoming an important tool for studying the pathophysiological mechanisms of cerebral blood flow in SNHL. Based on this, this article summarizes the latest progress of ASL in the assessment of cerebral blood flow perfusion in patients with SNHL, and explores the mechanisms underlying the changes in cerebral blood flow in these patients, so as to provide some references for clinical diagnosis and treatment as well as laboratory research.

Key words:

Arterial spin labeling, Sensorineural hearing loss, Blood perfusion, Magnetic resonance imaging, Progress

衣泳洁黄冉冉王爱杰黄翘路李朝蕙姜兴岳张国伟.

ASL技术在SNHL患者脑血流灌注评估中的研究进展 [J]. 国际医药卫生导报, 2025, 31(18): 2999-3003.

Yi Yongjie, Huang Ranran, Wang Aijie, Huang Qiaolu, Li Chaohui, Jiang Xingyue, Zhang Guowei.

Research progress of ASL in assessment of cerebral blood flow perfusion in patients with sensorineural hearing loss [J]. International Medicine and Health Guidance News, 2025, 31(18): 2999-3003.

参考文献

[1] 孙喜斌,魏志云,于丽玫,等. 中国听力残疾人群现状及致残原因分析[J]. 中华流行病学杂志,2008,29(7):643-646. DOI:10.3321/j.issn:0254-6450.2008.07.006.
[2] 唐晓旭,丁忠家,李佳林,等. 年龄相关性听力损失发病机制及防治研究进展[J]. 军事医学,2022,46(8):632-637. DOI:10.7644/j.issn.1674-9960.2022.08.013.
[3] Wang HH, Chen YT, Chou SF, et al. Effect of the timing of hyperbaric oxygen therapy on the prognosis of patients with idiopathic sudden sensorineural hearing loss[J]. Biomedicines, 2023, 11(10):2670. DOI: 10.3390/biomedicines11102670.
[4] 杨旻,朱晓燕,王旭. 感音神经性聋的代谢组学研究进展[J]. 山东大学耳鼻喉眼学报,2024,38(2):113-121. DOI:10.6040/j.issn.1673-3770.0.2023.263.
[5] 黄冉冉.职业性噪声聋患者的DTI联合静息态脑功能网络连接研究[D].济南:山东大学,2023.DOI:10.27272/d.cnki.gshdu.2023.000531.
[6] 仪晓立,赵鹏飞,吕晗,等. 基于影像学的耳聋诊疗与机制研究进展[J]. 中国医刊,2022,57(6):588-591. DOI:10.3969/j.issn.1008-1070.2022.06.003.
[7] Todic J, Guinand N, Lenoir V, et al. Diagnostic value and prognostic significance of MRI findings in sudden sensorineural hearing loss[J]. Laryngoscope Investig Otolaryngol, 2022, 7(5):1575-1583. DOI: 10.1002/lio2.922.
[8] Kim MB, Lim J, Moon IJ. Anatomical and pathological findings of magnetic resonance imaging in idiopathic sudden sensorineural hearing loss[J]. J Audiol Otol, 2020, 24(4):198-203. DOI: 10.7874/jao.2020.00157.
[9] Conte G, Di Berardino F, Mastrapasqua RF, et al. Prognostic value of early magnetic resonance imaging patterns in sudden hearing loss[J]. Audiol Neurootol, 2022,27(1):64-74. DOI: 10.1159/000515153.
[10] Wang Y, Wang Y, Wang Z, et al. Clinical value of a novel magnetic resonance imaging protocol and prognostic model establishment for sudden sensorineural hearing loss: a prospective study[J]. Audiol Neurootol, 2023,28(2):138-150. DOI: 10.1159/000527738.13.
[11] Yang CJ, Yoshida T, Sugimoto S, et al.Lesion-specific prognosis by magnetic resonance imaging in sudden sensorineural hearing loss[J]. Acta Otolaryngol, 2021, 141(1):5-9. DOI: 10.1080/00016489.2020.1827159.
[12] 李彦蓉,田果,曾群,等. HRCT三维重建在人工耳蜗植入术的临床应用研究[J]. 中国CT和MRI杂志,2024,22(5):52-54. DOI:10.3969/j.issn.1672-5131.2024.05.017.
[13] 徐重洋,蔡楚逸,周小君,等. 感音神经性耳聋人工耳蜗术前影像学检查应用进展[J]. 浙江中西医结合杂志,2023,33(1):95-98. DOI:10.3969/j.issn.1005-4561.2023.01.029.
[14] Chen Y, Li H, Liu B, et al. Cerebral blood flow pattern changes in unilateral sudden sensorineural hearing loss[J]. Front Neurosci, 2022,16:856710. DOI: 10.3389/fnins.2022.856710.
[15] 史文迪,胡娟,陈佳慧,等. 单侧听力损失的听力学诊断与干预策略[J]. 中华耳科学杂志,2024,22(5):856-860. DOI:10.3969/j.issn.1672-2922.2024.05.031.
[16] 李海梅,吕宽,陈悦,等. 基于三维准连续动脉自旋标记技术的单侧突发感音神经性耳聋患者脑血流灌注改变分析[J]. 中华医学杂志,2022,102(19):1417-1422. DOI:10.3760/cma.j.cn112137-20220113-00087.
[17] Williams DS, Detre JA, Leigh JS, et al. Magnetic resonance imaging of perfusion using spin inversion of arterial water[J]. Proc Natl Acad Sci U S A, 1992,89(1):212-216. DOI: 10.1073/pnas.89.1.212.
[18] 娄昕,吴冰,吴新淮,等.正常成人听皮层磁共振动脉自旋标记灌注成像的可重复性研究[J].中华耳科学杂志,2013,11(1):54-58. DOI:10.3969/j.issn.1672-2922.2013.01.012.
[19] 张晓晶,娄昕,张爱莲,等. 动脉自旋标记成像观察不同频率声音刺激下听觉皮层的脑血流量变化[J]. 中国病案,2018,19(6):110-112. DOI:10.3969/j.issn.1672-2566.2018.06.039.
[20] 张娟,汪文章,刘剑. 磁共振三维动脉自旋标记技术的应用研究进展[J]. 广西医学,2023,45(16):2016-2019,2034. DOI:10.11675/j.issn.0253-4304.2023.16.18.
[21] Wang K, Ma SJ, Shao X, et al. Optimization of pseudo-continuous arterial spin labeling at 7T with parallel transmission B1 shimming r[J]. Magn Reson Med, 2022 ,87(1):249-262. DOI: 10.1002/mrm.28988.
[22] Lee NG, Javed A, Jao TR, et al. Numerical approximation to the general kinetic model for ASL quantification[J]. Magn Reson Med, 2020,84(5):2846-2857. DOI: 10.1002/mrm.28304.
[23] 熊科亮,肖新兰,龚良庚,等. 突发性耳聋患者磁共振下内耳与听觉中枢血供的研究[J]. 江西医学院学报,2007,47(3):68-70,73. DOI:10.3969/j.issn.1000-2294.2007.03.021.
[24] 崔程凯,王爱杰,李忠维,等. 职业性噪声聋听觉中枢的动脉自旋标记MR研究[J]. 影像研究与医学应用,2023,7(13):39-42. DOI:10.3969/j.issn.2096-3807.2023.13.011.
[25] Shestopalova LB, Petropavlovskaia EA, Semenova VV, et al. Lateralization of brain responses to auditory motion: a study using single-trial analysis[J]. Neurosci Res, 2021,162:31-44. DOI: 10.1016/j.neures.2020.01.007.
[26] Li X, Zhao Y, Hui Y, et al. Lateralization of cerebral blood flow in the auditory cortex of patients with idiopathic tinnitus and healthy controls: an arterial spin labeling study[J]. Front Neurosci, 2022, 16:992758. DOI: 10.3389/fnins.2022.992758.
[27] Shibata DK, Kwok E. Temporal lobe perfusion in the deaf: MR measurement with pulsed arterial spin labeling (FAIR)[J]. Acad Radiol, 2006,13(6):738-743. DOI: 10.1016/j.acra.2006.02.037.
[28] Coez A, Fillon L, Saitovitch A, et al. Arterial spin labeling brain MRI study to evaluate the impact of deafness on cerebral perfusion in 79 children before cochlear implantation[J]. Neuroimage Clin, 2021, 29:102510. DOI: 10.1016/j.nicl.2020.102510.
[29] Zimmerman BJ, Schmidt SA, Khan RA, et al. Decreased resting perfusion in precuneus and posterior cingulate cortex predicts tinnitus severity[J]. Curr Res Neurobiol, 2021,2:100010. DOI: 10.1016/j.crneur.2021.100010.
[30] Hu J, Xu JJ, Shang S, et al. Cerebral blood flow difference between acute and chronic tinnitus perception: a perfusion functional magnetic resonance imaging study[J]. Front Neurosci, 2021, 15:752419. DOI: 10.3389/fnins.2021.752419.
[31] Xu ZG, Xu JJ, Chen YC, et al. Aberrant cerebral blood flow in tinnitus patients with migraine: a perfusion functional MRI study[J]. J Headache Pain, 2021,22(1):61. DOI: 10.1186/s10194-021-01280-0.
[32] Xia W, Cui J, Luo Y, et al. Glucose control has an impact on cerebral blood flow alterations in chronic tinnitus patients[J]. Front Neurosci, 2021,14:623520. DOI: 10.3389/fnins.2020.623520.
[33] Kannurpatti SS, Motes MA, Rypma B, et al. Neural and vascular variability and the fMRI-BOLD response in normal aging[J]. Magn Reson Imaging, 2010 ,28(4):466-476. DOI: 10.1016/j.mri.2009.12.007.
[34] 李鹤纯.基于功能磁共振的脑连接与微血管特征的关联机制研究[D]. 成都:电子科技大学,2022.DOI:10.27005/d.cnki.gdzku.2022.004825.
[35] Li X, Xu N, Dai C, et al. Altered neurovascular coupling in unilateral pulsatile tinnitus[J]. Front Neurosci, 2022, 15:791436. DOI: 10.3389/fnins.2021.791436.
[36] Xu XM, Jiao Y, Tang TY, et al Inefficient involvement of insula in sensorineural hearing loss[J]. Front Neurosci, 2019, 13:133. DOI: 10.3389/fnins.2019.00133.
[37] Feng C, Li S, Xing C, et al. Neurovascular coupling dysfunction associated with inflammatory factors in sudden sensorineural hearing loss[J]. Neuroscience, 2025, 568:130-138. DOI: 10.1016/j.neuroscience.2025.01.035.
[38] Ponticorvo S, Manara R, Pfeuffer J, et al. Cortical pattern of reduced perfusion in hearing loss revealed by ASL-MRI[J]. Hum Brain Mapp, 2019, 40(8):2475-2487. DOI: 10.1002/hbm.24538.
[39] Ponticorvo S, Manara R, Pfeuffer J, et al. Long-range auditory functional connectivity in hearing loss and rehabilitation[J]. Brain Connect, 2021,11(6):483-492. DOI: 10.1089/brain.2020.0814.
[40] Moon P, Theruvath J, Chang J, et al. MRI correlates of ototoxicity in the auditory pathway in children treated for medulloblastoma[J]. Otol Neurotol, 2022, 43(1):e97-e104. DOI: 10.1097/MAO.0000000000003336.
[41] Mostafa BE, Abdel Azim Y, Elfiky L. Diffusion tensor imaging and auditory tractography to evaluate cochlear implant candidacy: a pilot study[J]. Acta Otolaryngol, 2023 , 143(6):453-458. DOI: 10.1080/00016489.2023.2216234.

ASL技术在SNHL患者脑血流灌注评估中的研究进展

Research progress of ASL in assessment of cerebral blood flow perfusion in patients with sensorineural hearing loss

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

[1]	赵洲刘为朋李宗睿王睿智胡宝光. 高血压大鼠模型的研究现状 [J]. 国际医药卫生导报, 2025, 31(9): 1465-1470.
[2]	昝兴淳. 通督调神针刺治疗脑卒中后吞咽障碍的研究进展与展望 [J]. 国际医药卫生导报, 2025, 31(9): 1470-1474.
[3]	罗婷严婷何蕊. 基于超声弹性成像和MRI构建早期乳腺癌介入消融效果的预测模型 [J]. 国际医药卫生导报, 2025, 31(8): 1234-1239.
[4]	李强. 超声引导下射频消融治疗甲状腺微小乳头状癌的研究进展 [J]. 国际医药卫生导报, 2025, 31(8): 1258-1260.
[5]	洪金全黄震宇黄惠炆黄豪博. 胸苷酸合成酶基因在肿瘤发生发展中的研究进展 [J]. 国际医药卫生导报, 2025, 31(8): 1260-1265.
[6]	蒋萌赵静如刘惠刘庆新. 自噬与缺血性脑血管疾病的研究进展 [J]. 国际医药卫生导报, 2025, 31(8): 1265-1269.
[7]	刘汉清孙银萍赵强任帅. MSI-H/dMMR亚组局部晚期结直肠癌患者新辅助免疫治疗研究进展 [J]. 国际医药卫生导报, 2025, 31(8): 1270-1274.
[8]	朱鹏唐文玲覃刚. 结直肠癌中微小RNA功能及临床价值进展 [J]. 国际医药卫生导报, 2025, 31(6): 886-890.
[9]	潘文昕姜伟炜. 结肠镜检查时机对缺血性结肠炎患者预后影响的研究进展 [J]. 国际医药卫生导报, 2025, 31(6): 914-917.
[10]	张子怡孙大康. TRIM22抗HIV-1作用机制研究进展 [J]. 国际医药卫生导报, 2025, 31(6): 918-922.
[11]	易伟米倩倩赵洁李博宇王丹. 彩色多普勒血流成像在球后血流动力学检测中的应用 [J]. 国际医药卫生导报, 2025, 31(6): 922-926.
[12]	陈秀珠张凯韦岩笑丛晨阳. 甲状腺相关眼病的药物治疗研究进展 [J]. 国际医药卫生导报, 2025, 31(6): 927-929.
[13]	李晓童于胜强. 肾小管细胞来源外泌体在肾纤维化中的研究进展 [J]. 国际医药卫生导报, 2025, 31(5): 712-718.
[14]	张涵孙婷王延飞张肖林车娟. 移植后淋巴组织增生性疾病在儿童扁桃体腺样体肥大中的研究进展 [J]. 国际医药卫生导报, 2025, 31(5): 752-757.
[15]	莫家婵范万峰姜兴岳. 基于磁共振成像的影像组学在垂体腺瘤中的应用现状及进展 [J]. 国际医药卫生导报, 2025, 31(5): 757-760.