急性冠脉综合征患者炎症指数、血脂指标变化与冠状动脉病变严重程度的相关性

doi:10.3760/cma.j.cn441417-20241230-11004

摘要/Abstract

摘要：

目的　探讨急性冠脉综合征（ACS）患者炎症指数（SII）、血脂指标变化与冠状动脉病变严重程度的相关性。方法　选取2021年3月至2024年3月连云港市第一人民医院收治的100例ACS患者作为研究对象。男58例，女42例；年龄38～82（62.50±10.81）岁；体重指数18.20～32.60（25.31±3.52）kg/m²。根据病变血管支数，将患者分为单支病变组（25例）和多支病变组（75例）。根据Gensini评分，将患者分为轻度病变组（32例）和中重度病变组（68例）。比较单支病变组和多支病变组、轻度病变组和中重度病变组SII、血脂指标［总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）］。采用Spearman秩相关分析法分析ACS患者SII、血脂指标变化与冠状动脉病变严重程度的相关性。采用独立样本t检验进行统计学分析。结果　多支病变组TC、TG、LDL-C水平和SII均高于单支病变组，HDL-C水平低于单支病变组（均P<0.05）。中重度病变组TC、TG、LDL-C水平和SII均高于轻度病变组，HDL-C水平低于轻度病变组（均P<0.05）。Spearman秩相关分析结果显示，TC、TG、LDL-C水平和SII与冠状动脉病变严重程度均呈正相关，HDL-C水平与冠状动脉病变严重程度呈负相关（r=0.272、0.450、0.484、0.374、-0.479，均P<0.05）。结论　ACS患者SII升高及血脂代谢紊乱与冠状动脉病变严重程度密切相关，检测上述指标有助于评估患者病情和制定治疗方案。

关键词:

急性冠脉综合征, 炎症指数, 血脂, 冠状动脉病变严重程度, 相关性

Abstract:

Objective　To investigate the correlations between inflammation index (SII), blood lipid index and the severity of coronary artery disease in patients with acute coronary syndrome (ACS). Methods　A total of 100 patients with ACS who were admitted to the First People's Hospital of Lianyungang from March 2021 to March 2024 were selected as the research subjects. There were 58 males and 42 females; aged 38-82 (62.50±10.81) years; body mass index 18.20-32.60 (25.31±3.52) kg/m². According to the number of affected blood vessels, the patients were divided into the single-vessel disease group (25 cases) and the multiple-vessel disease group (75 cases). According to the Gensini score, the patients were divided into the mild disease group (32 cases) and the moderate and severe disease group (68 cases). Compare the SII and lipid indicators[total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C)] between the single-vessel disease group and the multi-vessel disease group, as well as between the mild disease group and the moderate and severe disease group. The Spearman rank correlation analysis method was used to analyze the correlation between the changes in SII and blood lipid index in ACS patients and the severity of coronary artery lesions. Independent sample t test was used for statistical analysis. Results　The levels of TC, TG, LDL-C and SII in the multi-vessel disease group were all higher than those in the single-vessel disease group, while the level of HDL-C was lower than that in the single-vessel disease group (all P<0.05). The levels of TC, TG, LDL-C and SII in the moderate and severe disease group were all higher than those in the mild disease group, while the level of HDL-C was lower than that in the mild disease group (all P<0.05). The Spearman rank correlation analysis results showed that the levels of TC, TG, LDL-C and SII were positively correlated with the severity of coronary artery lesions, while the level of HDL-C was negatively correlated with the severity of coronary artery lesions(r=0.272, 0.450, 0.484, 0.374, and -0.479, all P<0.05). Conclusion　The elevated SII level and lipid metabolism disorders in ACS patients are closely related to the severity of coronary artery lesions. The detection of these indicators is helpful for assessing the patient's condition and formulating treatment plans

Key words:

Acute coronary syndrome, Inflammation index, Blood lipid, Severity of coronary artery disease, Correlation

许玲吴红燕徐瑶尹德录.

急性冠脉综合征患者炎症指数、血脂指标变化与冠状动脉病变严重程度的相关性 [J]. 国际医药卫生导报, 2025, 31(11): 1780-1784.

Xu Ling, Wu Hongyan, Xu Yao, Yin Delu.

Correlations between inflammation index, blood lipid index and severity of coronary artery disease in patients with acute coronary syndrome [J]. International Medicine and Health Guidance News, 2025, 31(11): 1780-1784.

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