苯磺酸瑞马唑仑联合舒芬太尼在无痛胃镜检查中的应用

doi:10.3760/cma.j.cn441417-20240811-08025

国际医药卫生导报 ›› 2025, Vol. 31 ›› Issue (8): 1353-1357.DOI: 10.3760/cma.j.cn441417-20240811-08025

苯磺酸瑞马唑仑联合舒芬太尼在无痛胃镜检查中的应用

田道¹ 刘艳霞¹ 张盘石¹ 霍彦龙²

¹陕西省荣誉军人康复医院麻醉科，华阴 714200；²陕西省吴起县人民医院麻醉科，延安 717600

收稿日期:2024-08-11 出版日期:2025-04-15 发布日期:2025-04-21
通讯作者: 霍彦龙，Email：26723726@qq.com
基金资助:
陕西省自然科学研究项目（2018JM7125）

Application of remazolam benzenesulfonate and sufentanil in painless gastroscopy

Tian Dao¹, Liu Yanxia¹, Zhang Panshi¹, Huo Yanlong²

¹Department of Anesthesiology, Shaanxi Honorary Soldiers Rehabilitation Hospital, Huayin 714200, China; ²Department of Anesthesiology, Wuqi County People's Hospital, Yan'an 717600, China

Received:2024-08-11 Online:2025-04-15 Published:2025-04-21
Contact: Huo Yanlong, Email: 26723726@qq.com
Supported by:
Research Project of Natural Science in Shaanxi (2018JM7125)

摘要/Abstract

摘要：

目的　探讨苯磺酸瑞马唑仑联合舒芬太尼在无痛胃镜检查中的应用效果。方法　选取2023年6月至12月于陕西省荣誉军人康复医院接受无痛胃镜检查的120例患者进行随机对照试验，采用随机数字表法将其分为观察组和对照组，各60例。观察组男33例，女27例，年龄（45.62±14.85）岁。对照组男36例，女24例，年龄（46.15±11.08）岁。对照组采用舒芬太尼联合丙泊酚麻醉，观察组采用苯磺酸瑞马唑仑联合舒芬太尼麻醉。比较两组围手术期情况、不同时间点平均动脉压（mean arterial pressure，MAP）、心率（heart rate，HR）、简易精神状态检查量表（Mini-mental State Examination，MMSE）评分及不良反应发生率。采用t检验和χ²检验进行统计分析。结果　观察组麻醉起效时间、苏醒时间、复苏室停留时间分别为（1.56±0.41）min、（4.69±0.85）min、（28.77±2.64）min，均短于对照组的（1.99±0.54）min、（5.77±1.12）min、（31.06±3.83）min，差异均有统计学意义（t=4.913、5.950、3.813，均P<0.05）。观察组检查开始时、检查结束时MAP、HR分别为（85.94±7.21）mmHg （1 mmHg=0.133kPa）、（91.25±6.83）mmHg、（70.11±6.84）次/min、（78.13±6.18）次/min，均高于对照组的（81.66±6.31）mmHg、（85.61±6.95）mmHg、（65.47±6.70）次/min、（74.58±5.69）次/min，差异均有统计学意义（t=3.460、4.483、3.754、3.273，均P<0.05）。观察组苏醒后10 min、20 min时MMSE评分分别为（25.18±2.11）分、（27.18±1.63）分，均高于对照组的（23.57±1.95）分、（26.06±1.77）分，差异均有统计学意义（t=4.341、3.605，均P<0.05）。结论　在无痛胃镜检查患者中，应用苯磺酸瑞马唑仑联合舒芬太尼可维持术中血流动力学稳定，对患者术后认知功能影响更小。

关键词:

无痛胃镜, 苯磺酸瑞马唑仑, 舒芬太尼, 血流动力学, 认知功能

Abstract:

Objective　To investigate the effect of remazolam benzenesulfonate and sufentanil in painless gastroscopy. Methods　A total of 120 patients who received painless gastroscopy in Shaanxi Honorary Soldiers Rehabilitation Hospital from June to December 2023 were selected, and were divided into an observation group and a control group by the random number table method, with 60 cases in each group. There were 33 males and 27 females in the observation group who were (45.62±14.85) years old. There were 36 males and 24 females in the control group who were (46.15±11.08) years old. The control group were anesthetised with sufentanil and propofol, and the observation group with remazolam benzenesulfonate and sufentanil. The perioperative conditions, the mean arterial pressures (MAP), heart rates (HR), and scores of Mini-mental State Examination (MMSE) at different time points, and the incidence rates of adverse reactions were compared between the two groups. t and χ² tests were used for the statistical analysis. Results　The onset time of anesthesia, recovery time, and time staying in resuscitation room in the observation group were shorter than those in the control group [(1.56±0.41) min vs. (1.99±0.54) min, (4.69±0.85) min vs. (5.77±1.12) min, and (28.77±2.64) min vs. (31.06±3.83) min], with statistical differences (t=4.913, 5.950, and 3.813; all P<0.05). The MAP's and HR's at the beginning and end of the examination in the observation group were higher than those in the control group [(85.94±7.21) mmHg （1 mmHg=0.133kPa） vs. (81.66±6.31) mmHg, (91.25±6.83) mmHg vs. (85.61±6.95) mmHg, (70.11±6.84) times/min vs. (65.47±6.70) times/min, and (78.13±6.18) times/min vs. (74.58±5.69) times/min], with statistical differences (t=3.460, 4.483, 3.754, and 3.273; all P<0.05). The scores of MMSE 10 and 20 min after recovery in the observation group were higher than those in the control group (25.18±2.11 vs. 23.57±1.95 and 27.18±1.63 vs. 26.06±1.77), with statistical differences (t=4.341 and 3.605; both P<0.05). Conclusion　The application of remazolam benzenesulfonate and sufentanil in patients taking painless gastroscopy can maintain the stability of intraoperative hemodynamics and has less effect on postoperative cognitive function.

Key words:

Painless gastroscopy, Remazolam benzenesulfonate, Sufentanil, Hemodynamics, Cognitive function

田道刘艳霞张盘石霍彦龙.

苯磺酸瑞马唑仑联合舒芬太尼在无痛胃镜检查中的应用 [J]. 国际医药卫生导报, 2025, 31(8): 1353-1357.

Tian Dao, Liu Yanxia, Zhang Panshi, Huo Yanlong.

Application of remazolam benzenesulfonate and sufentanil in painless gastroscopy [J]. International Medicine and Health Guidance News, 2025, 31(8): 1353-1357.

参考文献

[1] Raderer M, Kiesewetter B, Mayerhoefer ME. Positron emission tomography/magnetic resonance imaging (PET/MRI) vs. gastroscopy: can it improve detection of extranodal marginal zone lymphomas of the stomach following H. pylori treatment?[J]. Expert Rev Hematol, 2022, 15(7): 565-571. DOI: 10.1080/17474086. 2022.2089110.
[2] 赵倩,杨振威,赵艳,等.体检人群胃镜检查发现胃癌及胃癌前疾病结果分析[J].临床消化病杂志,2022,34(1):26-30. DOI:10.3870/lcxh.j.issn.1005-541X.2022.01.006.
[3] 张雯,沈淼.苯磺酸瑞马唑仑联合阿芬太尼用于无痛胃肠镜患者的双盲对照研究[J].中国医院药学杂志,2023,43(1):61-64. DOI:10.13286/j.1001-5213.2023.01.10.
[4] 黄小梅,刘琳琳.不同负荷剂量苯磺酸瑞马唑仑复合舒芬太尼对妇科宫腔镜手术患者血流动力学的影响[J].中国现代医学杂志,2023,33(2):84-88. .DOI:10.3969/j.issn. 1005-8982.2023.02.014.
[5] 中华医学会消化内镜学分会麻醉协作组. 常见消化内镜手术麻醉管理专家共识[J]. 临床麻醉学杂志,2019,35(2):177-185. DOI:10.12089/jca.2019.02.019.
[6] Jin W, Huijie W, Ying X, et al. Microecology-turbidity toxin theory: correlation between helicobacter pylori infection and manifestation of tongue and gastroscopy[J]. J Tradit Chin Med, 2022, 42(3): 458-462.DOI: 10.19852/j.cnki.jtcm.20210612.001.
[7] 刘丹,高峰,孟黎辉.周末胃镜检查临床特征及患者特点分析 [J].中国病案,2023,24(8):108-110. DOI:10.3969/j.issn. 1672-2566.2023.08.036.
[8] 贾真,蔡汝忠,赵聪聪,等.不同麻醉方案对无痛胃镜检查患者术后复苏速度和恢复质量的影响[J].中华医学杂志,2024,104(31):2943-2948. DOI:10.3760/cma.j.cn112137- 20240126-00203.
[9] 刘文良,余雪美,熊朝晖.无痛胃肠镜患者丙泊酚复合舒芬太尼麻醉效果及麻醉复苏情况分析[J].河北医学,2023,29(5):872-876. DOI:10.3969/j.issn.1006-6233. 2023.05.034.
[10] 张珂,李洪图,张娜,等.阿芬太尼或舒芬太尼复合咪达唑仑与丙泊酚在无痛胃肠镜检查的效果[J].临床麻醉学杂志,2022,38(11):1163-1166. DOI:10.12089/jca.2022.11.008.
[11] 罗韵,徐国亭. 丙泊酚泵注下的全凭静脉麻醉与吸入麻醉在胃癌根治术全麻中的应用效果[J]. 国际医药卫生导报,2023,29(11):1541-1545. DOI:10.3760/cma.j.issn.1007-1245.2023.11.014.
[12] Coviello A, Iacovazzo C, D'Abrunzo A, et al. Sufentanil vs. dexmedetomidine as neuraxial adjuvants in cesarean section: a mono-centric retrospective comparative study [J]. J Clin Med, 2022, 11(22): 6868. DOI: 10.3390/jcm11226868.
[13] 黄凤南,徐城,崔珊珊,等.环泊酚单药与联合小剂量舒芬太尼在无痛胃镜检查中的麻醉效果比较[J].武汉大学学报(医学版), 2023, 44(5): 585-589. DOI:10.14188/j. 1671-8852. 2021.0800.
[14] 康鑫鑫,王中玉,周俊飞,等.苯磺酸瑞马唑仑联合阿芬太尼在肥胖患者无痛胃镜检查麻醉中的应用[J].中华实用诊断与治疗杂志,2022,36(7):744-746. DOI:10.13507/j.issn. 1674-3474.2022.07.022.
[15] 任青竹,杨寿娟,阮定红,等.苯磺酸瑞马唑仑复合阿芬太尼在老年患者无痛胃肠镜检查中的应用效果研究[J].河北医科大学学报,2023,44(3):338-341, 352. DOI:10.3969/j.issn.1007-3205.2023.03.019.
[16] 荣壮飞,魏登荣,陈丽萍,等.苯磺酸瑞马唑仑用于老年全身麻醉腰椎手术患者维持期对苏醒质量及认知功能的影响[J].颈腰痛杂志,2024,45(3):450-454. DOI:10.3969/j.issn.1005-7234.2024.03.012.
[17] 俞晓东,张文奇,康文越,等.瑞马唑仑联合舒芬太尼对行胸腔镜手术患者炎症因子及疼痛介质和应激反应指标水平的影响[J].中国医药,2022,17(1):93-97. DOI:10.3760/j.issn.1673-4777.2022.01.022.
[18] 郑敏,贾桂花,刘晶.苯磺酸瑞马唑仑与丙泊酚用于宫腔镜手术麻醉效果及对苏醒时间影响[J].中国计划生育学杂志,2022,30(1):63-66. DOI:10.3969/j.issn.1004-8189. 2022.01.014.
[19] 李进杰,张铁军.甲苯磺酸瑞马唑仑与丙泊酚用于深度镇静下三叉神经痛射频热凝术的比较研究[J].口腔医学研究,2023,39(11):973-977. DOI:10.13701/j.cnki.kqyxyj. 2023.11.007.
[20] 刘芳翔,刘双义,兰小娟,等.苯磺酸瑞马唑仑复合舒芬太尼在老年无痛胃镜检查中的临床应用[J].中国老年学杂志,2023,43(7):1584-1587. DOI:10.3969/j.issn.1005-9202. 2023.07.014.

苯磺酸瑞马唑仑联合舒芬太尼在无痛胃镜检查中的应用

Application of remazolam benzenesulfonate and sufentanil in painless gastroscopy

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