不同扳机方式对多囊卵巢综合征患者新鲜周期移植妊娠结局的影响比较

doi:10.3760/cma.j.issn.1007-1245.2022.07.011

国际医药卫生导报 ›› 2022, Vol. 28 ›› Issue (7): 933-936.DOI: 10.3760/cma.j.issn.1007-1245.2022.07.011

不同扳机方式对多囊卵巢综合征患者新鲜周期移植妊娠结局的影响比较

刘伟许丹丹童洁任建枝

中国人民解放军陆军第七十三集团军医院生殖医学中心，厦门　361000

收稿日期:2022-01-04 出版日期:2022-04-01 发布日期:2022-05-06
通讯作者: 童洁，Email：ly_2338abc@163.com
基金资助:
厦门市医学优势亚专科建设项目（厦卫科教【2018】296号文）

Effects of different trigger methods on pregnancy outcomes of IVF-ET in patients with polycystic ovary syndrome

Liu Wei, Xu Dandan, Tong Jie, Ren Jianzhi

Reproductive Medicine Center, Hospital of 73rd Army Group of Land Force, People's Liberation Army of China, Xiamen 361000, China

Received:2022-01-04 Online:2022-04-01 Published:2022-05-06
Contact: Tong Jie, Email: ly_2338abc@163.com
Supported by:
Project for Construction of Medical Subspecialties with advantages in Xiamen (No.2018296)

摘要/Abstract

摘要： 目的　比较不同扳机方式对多囊卵巢综合征患者在新鲜周期移植妊娠结局的影响。方法　回顾性分析中国人民解放军陆军第七十三集团军医院生殖医学中心2017年1月至2020年6月收治的多囊卵巢综合征并行体外受精-胚胎移植（IVF-ET）助孕的患者255例，在助孕过程中根据不同扳机方式分为：人绒毛膜促性腺激素（HCG）扳机组（HCG扳机组，81例）和促性腺激素释放激素激动剂（GnRH-a）联合低剂量HCG扳机组（联合扳机组，174例）。比较两组的一般资料、获卵数、可利用胚胎数、MⅡ卵率、临床妊娠率、持续妊娠率、早期流产率及卵巢过度刺激综合征（OHSS）发生率。采用t检验、χ²检验进行统计分析。结果　两组间获卵数、可利用胚胎数、MⅡ卵率、临床妊娠率、持续妊娠率、早期流产率比较，差异均无统计学意义（均P>0.05）。HCG扳机组的OHSS总发生率（6.17%，5/81）低于联合扳机组（0），差异有统计学意义（χ²=10.956，P=0.001）。结论　在多囊卵巢综合征患者行新鲜周期IVF-ET助孕过程中，GnRH-a联合低剂量HCG扳机更优，能减少OHSS的发生。

关键词: 多囊卵巢综合征, 促性腺激素释放激素激动剂, 临床妊娠率, 卵巢过度刺激综合征

Abstract: Objective　To compare the effects of different trigger methods on the pregnancy outcomes of in vitro fertilization and embryo transfer (IVF-ET) in patients with polycystic ovary syndrome. Methods　Two hundred and fifty-five patients with polycystic ovary syndrome who took IVF-ET assisted fertilization in Reproductive Medicine Center, Hospital of 73rd Army Group of Land Force, People's Liberation Army of China were retrospectively analyzed. According to the trigger methods, they were divided into a human chorionic gonadotropin (HCG) trigger group (HCG trigger group; 81 cases) and a gonadotropin releasing hormone agonist (GnRH-a) combined with a low dose of HCG trigger group (combined trigger group; 174 cases). The general data, numbers of eggs obtained, numbers of available embryos, rates of MⅡ eggs, clinical pregnancy rates, sustained pregnancy rates, early abortion rates, and incidences of ovarian hyperstimulation syndrome (OHSS) were compared between the two groups.t and χ² tests were applied. Results　There were no statistical differences in the number of eggs obtained, the number of available embryos, the rate of MⅡ eggs, the rate of clinical pregnancy, the rate of sustained pregnancy, and the rate of early abortion between the two groups (all P>0.05). The total incidence of OHSS of the combined trigger group was 6.17% (5/81), which was lower than that of the HCG trigger group (0), with a statistical difference (χ²=10.956，P=0.001). Conclusion　In patients with polycystic ovary syndrome undergoing a fresh cycle IVF-ET, GnRH-a combined with a low-dose HCG trigger is relatively better, and can reduce the occurrence of OHSS.

Key words: Polycystic ovary syndrome, Gonadotropin releasing hormone agonist, Clinical pregnancy rate, Ovarian hyperstimulation syndrome

刘伟, 许丹丹, 童洁, 任建枝. 不同扳机方式对多囊卵巢综合征患者新鲜周期移植妊娠结局的影响比较[J]. 国际医药卫生导报, 2022, 28(7): 933-936.

Liu Wei, Xu Dandan, Tong Jie, Ren Jianzhi. Effects of different trigger methods on pregnancy outcomes of IVF-ET in patients with polycystic ovary syndrome[J]. International Medicine and Health Guidance News, 2022, 28(7): 933-936.

参考文献

[1] March WA, Moore VM, Willson KJ, et al. The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria[J]. Hum Reprod, 2010,25(2):544-551. DOI: 10.1093/humrep/dep399.

[2] Chang WY, Knochenhauer ES, Bartolucci AA, et al. Phenotypic spectrum of polycystic ovary syndrome: clinical and biochemical characterization of the three major clinical subgroups[J]. Fertil Steril, 2005,83(6):1717-1723. DOI: 10.1016/j.fertnstert.2005.01.096.

[3] Blumenfeld Z. The Ovarian Hyperstimulation Syndrome[J]. Vitam Horm, 2018,107:423-451. DOI: 10.1016/bs.vh.2018.01.018.

[4] 王含必,温晓晓,汤鲜,等.低促性腺激素性性功能不全妇女IVF-ET治疗中的方法及疗效分析[J].中国计划生育学杂志,2017,25(5):318-322,327.DOI:10.3969/j.issn.1004-8189. 2017.05.003.

[5] 潘萍,杨冬梓.低剂量绒促性素与控制性卵巢刺激[J].实用妇产科杂志,2016,32(1):19-22.

[6] 林晓霞,谭展虹,蔡冰红,等.PCOS患者拮抗剂方案双扳机与绒促性素扳机方案的临床应用[J].中国处方药,2021,19(2):108-109.

[7] 胡秀玉,彭月婷,莫美兰,等.GnRH-a扳机对PCOS患者新鲜胚胎移植临床妊娠率的影响[J].生殖医学杂志,2019,28(8):890-895.DOI:10.3969/j.issn.1004-3845.2019.08.008.

[8] 李亚,刘敬,谢丽娟,等.不同扳机方式对多囊卵巢综合征高反应患者体外受精胚胎移植结局的影响[J].中国循证医学杂志,2019,19(9):1024-1029.DOI:10.7507/1672-2531. 201903062.

[9] 黄佳,汪利群.不同扳机方案在多囊卵巢综合征患者体外受精-胚胎移植中临床分析[J].医药导报,2020,39(6):824-827.DOI:10.3870/j.issn.1004-0781.2020.06.019.

[10] 覃慧斯,周红.拮抗剂方案扳机方式对体外受精结局影响的研究进展[J].中华生殖与避孕杂志,2020,40(10):789-793.DOI:10.3760/cma.j.cn101441-20190904-00399.

不同扳机方式对多囊卵巢综合征患者新鲜周期移植妊娠结局的影响比较

Effects of different trigger methods on pregnancy outcomes of IVF-ET in patients with polycystic ovary syndrome

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