关键词:

纤维支气管镜, 塑型性支气管炎, 儿童, 中性粒细胞百分比, D-二聚体

Abstract:

Objective　To investigate the efficacy of fiberbronchoscopy in the treatment of plastic bronchitis in children and its impact on the neutrophil percentage and D-dimer content, so as to provide more evidences on fiberbronchoscopy for plastic bronchitis in children, and provide guidance and reference for clinical treatment. Methods　Ninety-eight children with plastic bronchitis hospitalized in the First Hospital of Yulin between March 2020 and March 2023 were enrolled and were assigned into two groups according to different treatment approaches. In the control group, there were 21 females and 27 males, the age was (6.27±2.54) years old, and the course of disease was (2.57±0.74) d. There were 24 females and 26 males in the study group, the age was (6.34±2.48) years old, and the course of disease was (2.61±0.46) d. The control group was given conventional therapy, and the study group received fiberbronchoscopy on the basis of the control group. After 2 weeks of treatment, the disappearance time of clinical symptoms (cough, fever, shortness of breath, and lung moist rales) and clinical efficacies of the two groups were compared, and the changes in percentage of neutrophils, D-dimer content, and levels of inflammatory factors [tumor necrosis factor α (TNF-α), interleukin-6 (IL-6), and interferon-γ (IFN-γ)] were compared between the two groups before and after treatment. Independent sample t test and χ² test were used. Results　The disappearance time of cough, fever, shortness of breath, and lung moist rales in the study group were shorter than those in the control group (all P<0.05). The total effective rate of the control group was 81.25% (39/48), which was lower than that of the study group [96.00% (48/50)] (P<0.05). After treatment, the percentage of neutrophils [(53.12±7.81)%] and D-dimer content [(223.46±63.29) μg/L] in the study group were lower than those in the control group [(61.53±8.29)% and (287.65±76.58) μg/L] (both P<0.05); the levels of TNF-α, IL-6, and IFN-γ in the study group were lower than those in the control group (all P<0.05). Conclusion　Application of fiberbronchoscopy in the treatment of plastic bronchitis in children can effectively ameliorate the clinical symptoms, attenuate the inflammation response, reduce the percentage of neutrophils and D-dimer content, and facilitate the recovery of ventilatory function in children.

Key words:

Fiberbronchoscopy, Plastic bronchitis, Children, Percentage of neutrophils, D-dimer