关键词:

IgA肾病, 急性胰腺炎, 甲型流感病毒, 紫癜性肾炎, 免疫机制, 遗传

Abstract:

Immunoglobulin A (IgA) nephropathy is a common glomerular disease characterized by the deposition of IgA immune complexes in the glomerular mesangial regions. Its primary clinical manifestations are episodic gross hematuria and persistent microscopic hematuria, often accompanied by varying degrees of proteinuria. Some patients may present with nephrotic syndrome, acute nephritic syndrome, or rapidly progressive glomerulonephritis, and may also develop hypertension and renal function impairment. Acute pancreatitis is a condition marked by acute inflammation of the pancreas, primarily involving edema, hemorrhage, and necrosis of the pancreas, with severe abdominal pain, peritonitis, and shock as its main clinical features. Influenza A, an acute respiratory infectious disease caused by infection with the influenza A virus, is primarily airborne. Its subtypes are classified based on changes in hemagglutinin and neuraminidase surface proteins (i.e., antigenic shift and drift), with the subsequent spread, duration, and severity of influenza outbreaks depending on the susceptibility of the population, primarily manifesting as respiratory symptoms. While these three conditions are not uncommon clinically, their concurrent occurrence in the same patient is quite rare. This article reported an 11-year-old boy with IgA nephropathy who developed acute pancreatitis following an influenza A infection in Zhongshan People's Hospital, aiming to further explore the potential connections among the three diseases.

Key words:

IgA nephropathy, Acute pancreatitis, Influenza A virus, Anaphylactic purpura nephritis, Immunologic mechanism, Heredity