关键词:

急性大动脉粥样硬化, 补体C1q关联的肿瘤坏死因子相关蛋白5, 酶联免疫吸附法, 相关性分析

Abstract:

Objective　To explore the serum level of tumor necrosis factor-associated protein 5 (CTRP 5) in the course of patients with acute large atherosclerosis (ALAA) type cerebral infarction and its potential associations. Methods　This was a prospective study. One hundred and twelve patients with ALAA cerebral infarction who were hospitalized in Inner Mongolia Autonomous Region People's Hospital from December 2022 to August 2023 were selected as an ALAA cerebral infarction group, including 69 men and 43 women who were (64.25±9.42) years old. Fifty-five control individuals who had intracranial and external intracranial large artery atherosclerosis but no symptoms of cerebral infarction were selected as an LAA non-cerebral infarction group, including 36 men and 19 women who were (66.98±9.78) years old. Forty-one patients with large intracranial artery plaque were selected as a plaque group, including 18 men and 23 women who were (65.10±7.63) years old. Thirty-seven healthy subjects were selected as a normal group, including 18 men and 19 women who were (63.03±10.85) years old. The enzyme-linked immunosorbent assay (ELISA) was used to detect the serum CTRP 5 levels in all the participants. The serum CTRP 5 levels were compared between the ALAA cerebral infarction group and the non-cerebral infarction control groups (including the plaque group and the normal group). t test, nonparametric U test, and χ² test were used. Results　The serum CTRP 5 levels between the normal group and the other 3 groups (the ALAA cerebral infarction group, the LAA non-cerebral infarction group, and the plaque group), between the plaque group and the cerebral infarction group, and between the plaque group and the non-cerebral infarction group were statistically significant (F=5 259.50, 538.00, 5 327.00, 51 466.50, and 5 441.00; all P<0.05). The logistic regression analysis showed that the CTRP 5 level was positively correlated with the disease risk (OR=0.002, 95%CI 0-0.171). The ROC analysis of CTRP 5 showed that the area under the ROC was 0.937 (95%CI 0.895-0.980), demonstrating the effectiveness and accuracy of CTRP 5 in identifying cases of ALAA cerebral infarction. Conclusions　There is some correlation between serum CTRP 5 level and ALAA cerebral infarction and major atherosclerosis. No clear association is detected between serum CTRP 5 level and severity of neurological deficit. CTRP 5 level in serum is expected to be a potential biomarker for predicting ALAA cerebral infarction and assessing the risk of major atherosclerosis.

Key words:

Acute large artery atherosclerosis, Immunocomplement / C1q tumor necrosis factor-related protein 5, Enzyme-linked immunosorbent method, Analysis of correlation