血清NT-proBNP、CysC水平与2型糖尿病心肌肥厚患者左心室重构的相关性研究

doi:10.3760/cma.j.cn441417-20250605-19003

摘要/Abstract

摘要：

目的　分析血清N末端B型利钠肽原（NT-proBNP）、胱抑素C（CysC）水平与2型糖尿病心肌肥厚患者左心室重构的相关性。方法　选择2022年12月至2024年12月西安市第九医院收治的120例2型糖尿病心肌肥厚患者作为观察组，并选择同期本院接诊的100例单纯2型糖尿病患者作为单纯糖尿病组、100例健康人群作为健康对照组。观察组男58例、女62例，年龄（55.02±5.74）岁；单纯糖尿病组男47例、女53例，年龄（55.19±6.01）岁；健康对照组男50例、女50例，年龄（54.67±6.39）岁。比较3组受试者一般资料情况、室间隔厚度（IVST）、左室质量指数（LVMI）、左室射血分数（LVEF）、早期二尖瓣血流峰值（E）/晚期二尖瓣血流峰值（A）、E/左侧壁二尖瓣环早期峰值速度均值（e'）及血清NT-proBNP、CysC水平，采用Pearson相关性分析血清NT-proBNP、CysC水平与左心室重构指标的相关性。采用方差分析、χ²检验进行统计学分析。结果　观察组患者的IVST、LVMI、E/e'水平均高于单纯糖尿病组及健康对照组，LVEF、E/A均低于单纯糖尿病组及健康对照组（均P<0.05）；单纯糖尿病组、健康对照组各左心室重构功能指标比较差异均无统计学意义（均P>0.05）。观察组血清NT-proBNP、CysC水平均高于单纯糖尿病组及健康对照组［（528.96±39.19）ng/L比（177.69±23.28）ng/L、（175.29±27.60）ng/L；（1.27±0.27）mg/L比（0.94±0.20）mg/L、（0.84±0.22）mg/L］，单纯糖尿病组血清CysC水平高于健康对照组（均P<0.05）。Pearson相关性分析显示，血清NT-proBNP、CysC水平与IVST、LVMI、E/e'均呈正相关（均P<0.05），与LVEF、E/A均呈负相关（均P<0.05）。结论　血清NT-proBNP、CysC水平与2型糖尿病心肌肥厚患者左心室重构功能具有相关性，临床上应予以密切关注。

关键词:

2型糖尿病, 心肌肥厚, N末端B型利钠肽原, 胱抑素C, 左心室重构, 相关性

Abstract:

Objective　To analyze the correlations between the levels of serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) and cystatin C (CysC) and left ventricular remodeling in patients with type 2 diabetes and myocardial hypertrophy. Methods　From December 2022 to December 2024, 120 patients with type 2 diabetes and myocardial hypertrophy who were admitted to Xi'an Ninth Hospital were selected as the observation group. Meanwhile, 100 patients with simple type 2 diabetes and 100 healthy individuals were selected as the simple diabetes group and the healthy control group, respectively. In the observation group, there were 58 males and 62 females, with an age of (55.02±5.74) years old; in the simple diabetes group, there were 47 males and 53 females, with an age of (55.19±6.01) years old; in the healthy control group, there were 50 males and 50 females, with an age of (54.67±6.39) years old. The general conditions, interventricular septal thickness (IVST), left ventricular mass index (LVMI), left ventricular ejection fraction (LVEF), early diastolic mitral inflow velocity (E)/ late diastolic mitral inflow velocity (A), E/ early diastolic mitral annular tissue velocity (e'), and serum NT-proBNP and CysC levels of the three groups were compared. Pearson correlation analysis was used to analyze the correlations between serum NT-proBNP and CysC levels and left ventricular remodeling indicators. Statistical analysis was performed using the variance analysis and χ² test. Results　The levels of IVST, LVMI, and E/e' in the observation group were all higher than those in the simple diabetes group and the healthy control group, while the LVEF and E/A were lower than those in the simple diabetes group and the healthy control group (all P<0.05); there were no statistically significant differences in the left ventricular remodeling function indexes between the simple diabetes group and the healthy control group (all P>0.05). The levels of serum NT-proBNP and CysC in the observation group were higher than those in the simple diabetes group and the healthy control group [(528.96±39.19) ng/L vs. (177.69±23.28) ng/L and (175.29±27.60) ng/L; (1.27±0.27) mg/L vs. (0.94±0.20) mg/L and (0.84±0.22) mg/L], and the serum CysC level in the simple diabetes group was higher than that in the healthy control group (all P<0.05). Pearson correlation analysis showed that the levels of serum NT-proBNP and CysC were positively correlated with IVST, LVMI, and E/e' (all P<0.05), and negatively correlated with LVEF and E/A (all P<0.05). Conclusion　The levels of serum NT-proBNP and CysC are correlated with the left ventricular remodeling function in patients with type 2 diabetes and myocardial hypertrophy, and close attention should be paid to clinically.

Key words:

Type 2 diabetes, Myocardial hypertrophy, N-terminal pro-B-type natriuretic peptide, Cystatin C, Left ventricular remodeling, , Correlation

袁博王鑫季朝红马宏恩.

血清NT-proBNP、CysC水平与2型糖尿病心肌肥厚患者左心室重构的相关性研究 [J]. 国际医药卫生导报, 2025, 31(19): 3181-3186.

Yuan Bo, Wang Xin, Ji Zhaohong, Ma Hong'en.

Study on the correlations between serum NT-proBNP and CysC levels and left ventricular remodeling in patients with type 2 diabetes and myocardial hypertrophy [J]. International Medicine and Health Guidance News, 2025, 31(19): 3181-3186.

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