关键词:

大叶性肺炎, 中医药, 儿童, 随机对照试验, Meta分析

Abstract:

Objective　Based on a meta-analysis, the efficacy and safety of integrated traditional Chinese and western medicine in the treatment of pediatric lobar pneumonia were evaluated. Methods　Computerized searches were conducted in Web of Science, PubMed, Embase, CNKI, China Biomedical Literature Database, VIP Database, and Wanfang Database for randomized controlled trials on the integration of traditional Chinese and western medicine in the treatment of pediatric lobar pneumonia. The references of the included studies were also traced. Search by combining key words with free words. Search period: From database establishment to December 2024. Meta-analysis was conducted using RevMan 5.3 software, and funnel plots were used to assess publication bias. Results  A total of 15 articles were included. The results of the meta-analysis showed that there was a statistically significant difference in the efficacy rates between the two groups [RR=1.17, 95%CI (1.10, 1.25), P<0.000 01]. The efficacy rate of the observation group was 1.17 times that of the control group. The incidence of adverse reactions in the observation group was slightly lower than that in the control group [RR=0.73, 95%CI (0.47, 1.16), P=0.18]. The duration of fever reduction in the observation group was shorter than that in the control group [MD=-1.78, 95%CI (-2.14, -1.43), P<0.000 01]. The duration of cough disappearance in the observation group was shorter than that in the control group [MD=-2.74, 95%CI (-3.37, -2.10), P<0.000 01]. The duration of disappearance of lung rales in the observation group was shorter than that in the control group [MD=-3.01, 95%CI (-3.76, -2.25), P<0.000 01]. The level of C-reactive protein after treatment in the observation group was lower than that in the control group [MD=-3.18, 95%CI (-4.72, -1.63), P<0.000 01]. The decrease in the integrated score of traditional Chinese medicine syndromes before and after treatment in the observation group was higher than that in the control group [MD=4.98, 95%CI (0.31, 9.65), P=0.04]. A total of 15 articles were included in this study, covering 7 outcome indicators. After evaluating the publication bias of the overall effective rate, it was found that the funnel plot showed an asymmetrical distribution, suggesting the existence of publication bias risk. Conclusion  The combined treatment of traditional Chinese and western medicine for pediatric lobar pneumonia has a better effect, but more high-quality randomized controlled trials are still needed to further explore this issue.

Key words:

Lobar pneumonia, Traditional Chinese medicine, Children, Randomized controlled trial, Meta-analysis