关键词:

变应性鼻炎, 益气止鼽汤, 丙酸氟替卡松鼻喷雾剂, 肺虚感寒型, 临床疗效

Abstract:

Objective　To investigate the clinical efficacy of Yiqi Zhiqiu Decoction combined with fluticasone propionate nasal spray for patients with cold-induced allergic rhinitis of lung qi deficiency type. Methods　One hundred and fifty-nine patients with cold-induced allergic rhinitis of lung qi deficiency type treated at Shaanxi Provincial Hospital of Traditional Chinese Medicine from April 2022 to April 2024 were selected for the randomized controlled trial, and were divided into a control group (79 cases) and a treatment group (80 cases) by the random number table method. There were 41 males and 38 females in the control group; they were (55.2±6.7) years old; their body mass index (BMI) was (23.5±3.1) kg/m². There were 39 males and 41 females in the treatment group; they were (54.6±6.5) years old; their BMI was (23.8±3.2) kg/m². The control group took fluticasone propionate nasal spray, and the treatment group Yiqi Zhizhou Decoction combined with the nasal spray, for 4 weeks. The main observation indicators included treatment efficacy, traditional Chinese medicine syndrome scores, quality of life, inflammatory factors, immune levels, and adverse reactions. t and χ² tests were taken as the statistical methods. Results　The total effective rate in the treatment group was higher than that in the control group [96.25% (77/80) vs. 78.48% (62/79)], with a statistical difference (P<0.05). After the treatment, the scores of nasal congestion, cough, runny nose, sneezing, sputum, and short breath and fatigue were lower than those before the treatment group in both groups (all P<0.05), and the scores in the treatment group were better than those in the control group (0.58±0.13 vs. 1.31±0.18, 0.47±0.09 vs. 1.46±0.33, 0.62±0.09 vs. 1.76±0.41, 0.48±0.13 vs. 1.99±0.37, 0.53±0.11 vs. 1.27±0.22, and 0.44±0.08 vs. 1.43±0.28; all P<0.05). After the treatment, the scores of nasal, non-nasal, and ocular symptoms and daily activities, the levels of inflammatory factors [interleukin (IL) -6, IL-12, and interferon-γ], and immune levels [immunoglobulin (Ig) A, IgG, and IgE] were lower than those before the treatment in both groups, and those in the treatment group were lower than those in the control group (all P<0.05). Conclusion　Yiqi Zhiqiu Decoction combined with fluticasone propionate nasal spray for patients with cold-induced allergic rhinitis of lung qi deficiency type can improve their clinical symptoms and the treatment efficacy, so it is worth being clinically generalized.

Key words:

Allergic Rhinitis, Yiqi Zhiqiu , Decoction, Fluticasone propionate nasal spray, Lung qi deficiency type, Clinical efficacy