关键词: 糖尿病足, 抗菌药物, 感染病原菌, 合理用药

Abstract:

Objective　Through investigating and analyzing the use of antibacterial drugs and the distribution of pathogenic bacteria in patients with diabetes feet, to guide the clinical rational drug use and improve the management of antibacterial drugs in hospitals. Methods　A total of 2 990 inpatients with diabetes feet hospitalized in Jinan Central Hospital from January 2017 to December 2022 were retrospectively collected as the research objects, including 1 876 males and 1 114 females. There were 2 396 cases ≥65 years old and 594 cases <65. The use of antibacterial drugs and the distribution of pathogenic bacteria were analyzed. The antibacterial drug usage rates, proportions of use of various categories and dosage forms, antibacterial drug combination, and microbial submission rate were counted and analyzed. The Excel was used for data analysis and presentation. Results　Cephalosporins were the main antibacterial drugs used by the patients, accounting for 50.72% (843/1 662), and the most frequently used drug was ceftizoxime. The use frequency of restricted class antibacterial drugs was the highest, accounting for 56.56% (940/1 662). The intravenous administration was the main method for using antibacterial drugs, accounting for 84.09% (2 473/2 941). The microbial submission rate reached 43.14% (717/1 662). Staphylococcus aureus was the most common pathogenic bacteria, with a detection rate of 35.84% (257/717). Conclusions　There are many kinds of antibacterial drugs used by hospitalized patients with diabetes feet. The use frequencies of restricted and special class antibacterial drugs are high. The microbial submission rates in the patients who use the restricted and special class antibacterial drugs do not meet the national regulations. There are unreasonable phenomena in the use of antibacterial drugs in Jinan Central Hospital. Therefore, it's necessary to strengthen the training of relevant regulations and management of antibacterial drug usage, in order to reduce the occurrence of clinical unreasonable drug usage.

Key words: Diabetes foot,  , Antibacterial drugs,  , Pathogenic bacteria,  , Rational drug use