关键词: 体外受精, 卵胞质内单精子注射, 无可移植胚胎, 女方年龄, 不孕类型, 再次助孕

Abstract:

Objective　To investigate the willingness and influencing factors of patients who underwent their first in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatment at Reproductive Medical Center, Department of Obstetrics and Gynecology, Tianjin Medical University General Hospital and had no transferable embryos to undergo IVF/ICSI again. Methods　A retrospective analysis was performed on 375 patients who underwent their first IVF/ICSI treatment at Reproductive Medical Center, Department of Obstetrics and Gynecology, Tianjin Medical University General Hospital from January 2016 to October 2024 and had no transferable embryos. As of April 2025, the patients were divided into a return visit group (280 cases) and a non-return visit group (95 cases) according to whether they underwent IVF/ICSI again at our center. The clinical data of the two groups were collected and analyzed through an electronic medical record system, and the factors potentially influencing repeated assisted reproduction were statistically analyzed. Further analysis was performed on the 280 couples who returned, and they were divided into a within-half-a-year return visit group (218 cases) and a beyond-half-a-year return visit group (62 cases) according to whether they underwent IVF/ICSI again within half a year. Independent sample t test and χ² test were used to compare the differential indicators between the two groups. The binary logistic regression was used to observe the influencing factors of the willingness to return within half a year. Results　The proportion of the patients with no transferable embryos who underwent IVF/ICSI again was 74.67% (280/375). Comparing the data characteristics between the return visit group and the non-return visit group, there were statistical differences in male age and female age (both P<0.050), while there were no statistical differences in infertility type, infertility duration, infertility indication, whether having children, residence in Tianjin, and number of oocytes retrieved (all P>0.05). The logistic regression showed that whether to undergo repeated assisted reproduction in the patients with no transferable embryos after the first IVF/ICSI was significantly correlated with the couple's age (P=0.015, OR=1.057, 95%CI 1.011-1.106). In the return visit group, the number of oocytes retrieved in the first IVF/ICSI (P=0.046, OR=1.063, 95%CI 1.001-1.128) and the type of infertility (P=0.002, OR=2.707, 95%CI 1.425-5.139) were associated with whether the patients underwent repeated assisted reproduction within half a year. Conclusions　The couple's age is an important factor affecting the willingness of patients with no embryos after the first IVF/ICSI treatment to undergo repeated assisted reproduction. The total number of oocytes retrieved in the first IVF/ICSI and the type of infertility may predict whether patients will return for repeated assisted reproduction within half a year.

Key words: Vitro fertilization,  , Intracytoplasmic sperm injection,  , No transplantable embryos,  , Female age,  , Type of infertility,  , Assisted reproduction again