中医序贯疗法治疗反复胚胎种植失败患者妊娠结局相关因素分析

doi:10.3760/cma.j.cn441417-20250326-14002

摘要/Abstract

摘要：

目的　分析影响中医序贯疗法治疗反复胚胎种植失败（RIF）患者妊娠结局相关因素。方法　采用回顾性研究设计，选取2022年8月至2023年12月在广东省妇幼保健院接受胚胎移植的RIF患者48例，均在移植前后接受中医序贯疗法，按妊娠结局分为成功组（25例，活产）和失败组（23例），成功组患者年龄（33.1±5.3）岁，胚胎种植失败次数2～7次；失败组患者年龄（35.2±5.7）岁，胚胎种植失败次数2～8次。比较两组基本资料、优质胚胎数/率、促性腺激素（Gn）总用量、Gn启动时雌二醇（E2）水平。采用t检验进行统计比较，Spearman分析优质胚胎数/率、Gn总用量、Gn启动时E2水平与妊娠结局的相关性。结果　两组基本资料比较差异均无统计学意义（均P>0.05）。成功组优质胚胎数为（8.9±5.3）个，优质胚胎率为73.0（58.0，88.0）%，Gn启动时E2水平38.5（9.1，206.1）pmol/L，高于失败组［（5.9±4.8）个、67.0（33.0，80.0）%、32.2（25.9，54.1）pmol/L］；Gn总用量为800（1 500，2 550）IU，少于失败组［1 950（1 500，2 700）IU］；两组比较，差异均有统计学意义（均P<0.05）。优质胚胎数/率、Gn总用量及Gn启动时E2水平与RIF患者妊娠结局存在相关性（r=0.305、0.182、-0.117、0.287）。结论　优质胚胎数/率、Gn总用量及Gn启动时E2水平与RIF患者妊娠结局存在相关性。

关键词: 妊娠结局, 反复胚胎种植失败, 中医序贯疗法, 优质胚胎, 激素水平, 相关性

Abstract:

Objective　To analyze pregnancy outcome factors of traditional Chinese medicine sequential therapy for patients with repeated embryo implantation failure (RIF). Methods　A total of 48 patients with RIF who underwent embryo transfer in Guangdong Women and Children Hospital from August 2022 to December 2023 were selected for the retrospective study. All the patients took traditional Chinese medicine sequential therapy before and after embryo transfer. They were divided into a success group (25 cases, live birth) and a failure group (23 cases) according to the pregnancy outcomes. The success group were (33.1±5.3) years old, and had 2-7 times of embryo implantation failure. The failure group were (35.2±5.7) years old, and had 2-8 times of embryo implantation failure. The basic data, high-quality embryo numbers/rates, total gonadotropins (Gn) dosages, and estradiol (E2) levels at Gn initiation were compared between the two groups by t test. The correlations of the high-quality embryo number/rate, total Gn dosage, and E2 level at Gn initiation with pregnancy outcomes were analyzed by Spearman. Results　There were no statistical differences in the basic data between the two groups (all P>0.05). The high-quality embryo number and rates and E2 level at Gn initiation in the success group were higher than those in the failure group [8.9±5.3 vs. 5.9±4.8, 73.0 (58.0,88.0)% vs. 67.0 (33.0,80.0)%, and 38.5 (9.1, 206.1) pmol/L vs. 32.2 (25.9, 54.1) pmol/L], and the total Gn dosage was lower [800 (1 500, 2 550) IU vs. 1 950(1 500, 2 700) IU], with statistical differences between the two groups (all P<0.05).The number/rate of high-quality embryos, the total dosage of Gn, and the E2 level at the time of Gn initiation were correlated with the patients' pregnancy outcomes (r = 0.305, 0.182, -0.117, and 0.287). Conclusion　The number/rate of high-quality embryos, total Gn dosage, and E2 level at Gn initiation are correlated with the pregnancy outcomes of patients with RIF.

Key words: Pregnancy outcomes, , Repeated embryo implantation failure, , Traditional Chinese medicine sequential therapy, , High-quality embryos, , Hormone level, , Dependency

宋曙霞潘明沃何田田朱玲.

中医序贯疗法治疗反复胚胎种植失败患者妊娠结局相关因素分析 [J]. 国际医药卫生导报, 2025, 31(14): 2294-2298.

Song Shuxia, Pan Mingwo, He Tiantian, Zhu Ling.

Pregnancy outcome factors of traditional Chinese medicine sequential therapy for patients with repeated embryo implantation failure [J]. International Medicine and Health Guidance News, 2025, 31(14): 2294-2298.

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