静息态功能磁共振在卒中后失语治疗中的研究进展

doi:10.3760/cma.j.cn441417-20241211-12009

国际医药卫生导报 ›› 2025, Vol. 31 ›› Issue (12): 1975-1979.DOI: 10.3760/cma.j.cn441417-20241211-12009

静息态功能磁共振在卒中后失语治疗中的研究进展

解丽雯^1,2 梁志刚²

¹滨州医学院第二临床医学院,烟台 264003；²青岛大学附属烟台毓璜顶医院神经内科，烟台 264000

收稿日期:2024-12-11 出版日期:2025-06-15 发布日期:2025-06-15
通讯作者: 梁志刚，Email：zgliang@hotmail.com
基金资助:
山东省医药卫生科技项目（202303070650）；烟台市科技计划（2021YD033）

Research progress of resting state functional magnetic resonance imaging in treatment of post-stroke aphasia

Xie Liwen^1,2, Liang Zhigang²

¹Second Clinical Medical College, Binzhou Medical University, Yantai 264003, China; ²Department of Neurology, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai 264000, China

Received:2024-12-11 Online:2025-06-15 Published:2025-06-15
Contact: Liang Zhigang, Email: zgliang@hotmail.com
Supported by:
Project of Medical and Health Science and Technology in Shandong Province (202303070650); Plan of Science and Technology in Yantai (2021YD033)

摘要/Abstract

摘要：

卒中后失语（post-stroke aphasia，PSA）作为脑卒中患者常见的并发症，其高致残性严重降低患者的生活质量，并对社会造成沉重负担。康复机制不明导致PSA患者的治疗难以精准。静息态功能磁共振能在无任务执行的状态下观察患者大脑局部及整体脑网络连接变化，是探索PSA恢复机制及科学预测预后的重要工具。本文从静息态功能磁共振角度出发，围绕该技术在观察及预测PSA患者脑功能变化方面进行文献回顾，以期进一步指导PSA患者的康复治疗实践。

关键词: 卒中后失语, 静息态功能磁共振, 恢复机制, 脑网络, 进展

Abstract:

Post-stroke aphasia (PSA) as one of the common complications in stroke patients, its high disability rate seriously reduces the patients' quality of life and imposes a heavy burden on society. The unclear rehabilitation mechanism makes it difficult to treat patients with PSA accurately. Resting-state functional magnetic resonance imaging (rs-fMRI) can observe changes in the patients' local and overall brain network connections in a task-free state, and is an important tool for exploring the recovery mechanism of PSA and scientifically predicting the prognosis. Starting from the perspective of rs-fMRI, this article reviews the literature on the observation and prediction of brain function changes in patients with PSA, so as to further guide the rehabilitation treatment practice of patients with PSA.

Key words: Post-stroke aphasia, , Resting state functional magnetic resonance, , Recovery mechanism, , Brain network, , Progress

解丽雯梁志刚. 静息态功能磁共振在卒中后失语治疗中的研究进展 [J]. 国际医药卫生导报, 2025, 31(12): 1975-1979.

Xie Liwen, Liang Zhigang.

Research progress of resting state functional magnetic resonance imaging in treatment of post-stroke aphasia [J]. International Medicine and Health Guidance News, 2025, 31(12): 1975-1979.

参考文献

[1]Brady MC, Kelly H, Godwin J, et al. Speech and language therapy for aphasia following stroke[J]. Cochrane Database Syst Rev, 2012(5):CD000425. DOI: 10.1002/14651858.CD000425.pub3.

[2]Lazar RM, Boehme AK. Aphasia as a predictor of stroke outcome[J]. Curr Neurol Neurosci Rep, 2017,17(11):83. DOI: 10.1007/s11910-017-0797-z.

[3]Crosson B, Rodriguez AD, Copland D, et al. Neuroplasticity and aphasia treatments: new approaches for an old problem[J]. J Neurol Neurosurg Psychiatry, 2019,90(10):1147-1155. DOI: 10.1136/jnnp-2018-319649.

[4]韩杨,张辉.卒中后失语症的静息态功能磁共振成像相关研究进展[J].磁共振成像,2023,14(3):153-158. DOI:10.12015/issn.1674-8034.2023.03.028.

[5]Amemiya S, Takao H, Abe O. Resting-state fmri: emerging concepts for future clinical application[J]. J Magn Reson Imaging, 2024,59(4):1135-1148. DOI: 10.1002/jmri.28894.

[6]Hartwigsen G, Saur D. Neuroimaging of stroke recovery from aphasia - insights into plasticity of the human language network[J]. Neuroimage, 2019,190:14-31. DOI: 10.1016/j.neuroimage.2017.11.056.

[7]Arheix-Parras S, Barrios C, Python G, et al. A systematic review of repetitive transcranial magnetic stimulation in aphasia rehabilitation: leads for future studies[J]. Neurosci Biobehav Rev, 2021,127:212-241. DOI: 10.1016/j.neubiorev.2021.04.008.

[8]Hope TMH, Leff AP, Prejawa S, et al. Right hemisphere structural adaptation and changing language skills years after left hemisphere stroke[J]. Brain, 2017,140(6):1718-1728. DOI: 10.1093/brain/awx086.

[9]Hillis AE. The 'standard' for poststroke aphasia recovery[J]. Stroke, 2010,41(7):1316-1317. DOI: 10.1161/STROKEAHA.110.585364.

[10]Godecke E, Armstrong E, Rai T, et al. A randomized control trial of intensive aphasia therapy after acute stroke: the Very Early Rehabilitation for SpEech (VERSE) study[J]. Int J Stroke, 2021,16(5):556-572. DOI: 10.1177/1747493020961926.

[11]Reuter B, Gumbinger C, Sauer T, et al. Access, timing and frequency of very early stroke rehabilitation - insights from the Baden-Wuerttemberg stroke registry[J]. BMC Neurol, 2016,16(1):222. DOI: 10.1186/s12883-016-0744-7.

[12]Stockbridge MD, Faria AV, Fridriksson J, et al. Subacute aphasia recovery is associated with resting-state connectivity within and beyond the language network[J]. Ann Clin Transl Neurol, 2023,10(9):1525-1532. DOI: 10.1002/acn3.51842.

[13]McClung JS, Rothi LJ, Nadeau SE. Ambient experience in restitutive treatment of aphasia[J]. Front Hum Neurosci, 2010,4:183. DOI: 10.3389/fnhum.2010.00183.

[14]Iadecola C, Anrather J. The immunology of stroke: from mechanisms to translation[J]. Nat Med, 2011,17(7):796-808. DOI: 10.1038/nm.2399.

[15]Feng T, Zhang C, Xu S, et al. A right convergence area of the prefrontal lobe is involved in the improvement of semantic fluency in patients with post-stroke aphasia[J]. Top Stroke Rehabil, 2024,31(3):301-310. DOI: 10.1080/10749357.2023.2253632.

[16]Butler RA, Lambon Ralph MA, Woollams AM. Capturing multidimensionality in stroke aphasia: mapping principal behavioural components to neural structures[J]. Brain, 2014,137(Pt 12):3248-3266. DOI: 10.1093/brain/awu286.

[17]Stefaniak JD, Geranmayeh F, Lambon Ralph MA. The multidimensional nature of aphasia recovery post-stroke[J]. Brain, 2022,145(4):1354-1367. DOI: 10.1093/brain/awab377.

[18]Katsuno Y, Ueki Y, Ito K, et al. Effects of a new speech support application on intensive speech therapy and changes in functional brain connectivity in patients with post-stroke aphasia[J]. Front Hum Neurosci, 2022,16:870733. DOI: 10.3389/fnhum.2022.870733.

[19]Yang Q, Xu S, Chen M, et al. Effects of the left M1 iTBS on brain semantic network plasticity in patients with post-stroke aphasia: a preliminary study[J]. J Integr Neurosci, 2023,22(1):24. DOI: 10.31083/j.jin2201024.

[20]Zheng K, Chen M, Shen Y, et al. Cerebellar continuous theta burst stimulation for aphasia rehabilitation: study protocol for a randomized controlled trial[J]. Front Aging Neurosci, 2022,14:909733. DOI: 10.3389/fnagi.2022.909733.

[21]Sebastian R, Kim JH, Brenowitz R, et al. Cerebellar neuromodulation improves naming in post-stroke aphasia[J]. Brain Commun, 2020,2(2):fcaa179. DOI: 10.1093/braincomms/fcaa179.

[22]van Hees S, McMahon K, Angwin A, et al. A functional MRI study of the relationship between naming treatment outcomes and resting state functional connectivity in post-stroke aphasia[J]. Hum Brain Mapp, 2014,35(8):3919-3931. DOI: 10.1002/hbm.22448.

[23]Iorga M, Higgins J, Caplan D, et al. Predicting language recovery in post-stroke aphasia using behavior and functional MRI[J]. Sci Rep, 2021,11(1):8419. DOI: 10.1038/s41598-021-88022-z.

[24]Falconer I, Varkanitsa M, Kiran S. Resting-state brain network connectivity is an independent predictor of responsiveness to language therapy in chronic post-stroke aphasia[J]. Cortex, 2024,173:296-312. DOI: 10.1016/j.cortex.2023.11.022.

[25]Kang EK, Kim YK, Sohn HM, et al. Improved picture naming in aphasia patients treated with cathodal tDCS to inhibit the right Broca's homologue area[J]. Restor Neurol Neurosci, 2011,29(3):141-152. DOI: 10.3233/RNN-2011-0587.

[26]Yao L, Zhao H, Shen C, et al. Low-frequency repetitive transcranial magnetic stimulation in patients with poststroke aphasia: systematic review and meta-analysis of its effect upon communication[J]. J Speech Lang Hear Res, 2020,63(11):3801-3815. DOI: 10.1044/2020_JSLHR-19-00077.

[27]Alemanno F, Fedeli D, Monti A, et al. Increased interhemispheric functional connectivity after right anodal tDCS in chronic non-fluent aphasia: preliminary findings[J]. Front Neurosci, 2024,18:1346095. DOI: 10.3389/fnins.2024.1346095.

[28]Barbancho MA, Berthier ML, Navas-Sánchez P, et al. Bilateral brain reorganization with memantine and constraint-induced aphasia therapy in chronic post-stroke aphasia: an ERP study[J]. Brain Lang, 2015, 145-146:1-10. DOI: 10.1016/j.bandl.2015.04.003.

[29]Chollet F, Tardy J, Albucher JF, et al. Fluoxetine for motor recovery after acute ischaemic stroke (FLAME): a randomised placebo-controlled trial[J]. Lancet Neurol, 2011,10(2):123-130. DOI: 10.1016/S1474-4422(10)70314-8.

[30]Saxena S, Hillis AE. An update on medications and noninvasive brain stimulation to augment language rehabilitation in post-stroke aphasia[J]. Expert Rev Neurother, 2017,17(11):1091-1107. DOI: 10.1080/14737175.2017.1373020.

静息态功能磁共振在卒中后失语治疗中的研究进展

Research progress of resting state functional magnetic resonance imaging in treatment of post-stroke aphasia

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

[1]	赵洲刘为朋李宗睿王睿智胡宝光. 高血压大鼠模型的研究现状 [J]. 国际医药卫生导报, 2025, 31(9): 1465-1470.
[2]	昝兴淳. 通督调神针刺治疗脑卒中后吞咽障碍的研究进展与展望 [J]. 国际医药卫生导报, 2025, 31(9): 1470-1474.
[3]	张婷郭淋张驰付瑞崔治权康晓刚. 青少年双相情感障碍患者血脂水平与区域性脑结构的相关性研究 [J]. 国际医药卫生导报, 2025, 31(9): 1538-1543.
[4]	李强. 超声引导下射频消融治疗甲状腺微小乳头状癌的研究进展 [J]. 国际医药卫生导报, 2025, 31(8): 1258-1260.
[5]	洪金全黄震宇黄惠炆黄豪博. 胸苷酸合成酶基因在肿瘤发生发展中的研究进展 [J]. 国际医药卫生导报, 2025, 31(8): 1260-1265.
[6]	蒋萌赵静如刘惠刘庆新. 自噬与缺血性脑血管疾病的研究进展 [J]. 国际医药卫生导报, 2025, 31(8): 1265-1269.
[7]	刘汉清孙银萍赵强任帅. MSI-H/dMMR亚组局部晚期结直肠癌患者新辅助免疫治疗研究进展 [J]. 国际医药卫生导报, 2025, 31(8): 1270-1274.
[8]	朱鹏唐文玲覃刚. 结直肠癌中微小RNA功能及临床价值进展 [J]. 国际医药卫生导报, 2025, 31(6): 886-890.
[9]	潘文昕姜伟炜. 结肠镜检查时机对缺血性结肠炎患者预后影响的研究进展 [J]. 国际医药卫生导报, 2025, 31(6): 914-917.
[10]	张子怡孙大康. TRIM22抗HIV-1作用机制研究进展 [J]. 国际医药卫生导报, 2025, 31(6): 918-922.
[11]	易伟米倩倩赵洁李博宇王丹. 彩色多普勒血流成像在球后血流动力学检测中的应用 [J]. 国际医药卫生导报, 2025, 31(6): 922-926.
[12]	陈秀珠张凯韦岩笑丛晨阳. 甲状腺相关眼病的药物治疗研究进展 [J]. 国际医药卫生导报, 2025, 31(6): 927-929.
[13]	李晓童于胜强. 肾小管细胞来源外泌体在肾纤维化中的研究进展 [J]. 国际医药卫生导报, 2025, 31(5): 712-718.
[14]	张涵孙婷王延飞张肖林车娟. 移植后淋巴组织增生性疾病在儿童扁桃体腺样体肥大中的研究进展 [J]. 国际医药卫生导报, 2025, 31(5): 752-757.
[15]	莫家婵范万峰姜兴岳. 基于磁共振成像的影像组学在垂体腺瘤中的应用现状及进展 [J]. 国际医药卫生导报, 2025, 31(5): 757-760.