关键词:

慢性阻塞性肺疾病, 血嗜酸性粒细胞, 呼出气一氧化氮, 肺功能

Abstract:

Objective　To analyze the correlations between blood eosinophils (EOS) and fractional concentration of exhaled nitric oxide (FeNO) levels and lung function in patients with chronic obstructive pulmonary disease (COPD). Methods　A total of 200 patients with COPD treated in Xuzhou First People's Hospital from October 2019 to June 2023 were selected as the study objects and were set as the observation group. Among them, there were 138 males and 62 females, aged 55-88 (66.45±5.45) years, and the course of disease was 1-18 (10.23±3.23) years. According to the disease stage, the observation group was divided into an acute attack group (150 cases) and a stable stage group (50 cases). Another 100 patients with non-COPD who were hospitalized during the same period were selected as the control group. The general data, such as smoking history, drinking history, underlying diseases, and body mass index (BMI), were collected from the 300 subjects. The EOS level was detected by automatic blood cell analyzer, the FeNO level was detected by FeNO detector, and the lung function was detected by lung function detector. The correlations between EOS and FeNO levels in peripheral blood and lung function of COPD patients were analyzed by Pearson correlation analysis. Independent sample t test, F test, and χ² test were used. Results　The proportion of smoking history in the observation group [52.50% (105/200)] was higher than that in the control group [17.00% (17/100)] (P<0.05). The levels of EOS [(6.23±0.21)%, (6.42±0.58)%] and FeNO [(35.52±7.28) ppb, (46.28±7.08) ppb] in peripheral blood of the stable stage and acute attack groups were higher than those of the control group [(2.23±0.59)%, (15.23±7.34) ppb], and the FeNO level in the acute attack group was higher than that in the stable stage group (all P<0.05). The forced vital capacity (FVC) [(2.18±0.18) L, (2.16±0.15) L], forced expiratory volume in the first second (FEV1) [(1.16±0.31) L, (1.14±0.28) L], FEV1/FVC [(60.56±8.24)%, (59.23±8.21)%], and FEV1% [(65.23±8.59)%, (64.11±8.12)%] in the stable stage and acute attack groups were lower than those in the control group [(3.16±0.38) L, (2.21±0.41) L, (82.28±9.16)%, and (89.62±5.23)%] (all P<0.05). Pearson correlation analysis showed that the EOS level in peripheral blood of COPD patients was positively correlated with FeNO level (r=0.584, P=0.002), and negatively correlated with FEV1/FVC (r=-0.213, P=0.005). Conclusions　There is a significant correlation between EOS% and FeNO level as well as lung function in COPD patients. Clinically, changes in their levels can be used to assess the patients' condition and provide guidance for later treatment.

Key words:

Chronic obstructive pulmonary disease, Blood eosinophils, Fractional concentration of exhaled nitric oxide, Lung function