关键词:

慢性阻塞性肺疾病, 活化部分凝血活酶时间, 系统性红斑狼疮, 抗磷脂综合征

Abstract:

Activated partial thromboplastin time (APTT) is a common screening test for coagulation. Multiple causes, such as coagulation factor deficiency, presence of coagulation factor inhibitors, or lupus anticoagulants, can lead to prolonged APTT, but the treatment options and outcomes are quite different. This article reports the diagnosis and treatment of a patient with chronic obstructive pulmonary disease and persistent prolonged APTT. The patient had a previous diagnosis of chronic bronchitis and was admitted to Nanyang Central Hospital on December 6, 2021 because of fever and shortness of breath exacerbated after activity. He was initially found to have a significantly prolonged APTT (up to the critical value criteria), which was not corrected by plasma infusion and vitamin K. The APTT mixing test indicated antiphospholipid syndrome. The patient's conditions were improved significantly after hormonal treatment. This report is intended to deepen clinicians' understanding of the APTT mixing test, to improve the application of this test in primary testing laboratories, and to help clinicians quickly identify patients at risk for bleeding or thrombosis and reduce missed diagnoses and misdiagnoses.

Key words:

Chronic obstructive pulmonary disease, Activated partial thromboplastin time, Systemic lupus erythematosus, Antiphospholipid syndrome