脑源性神经营养因子在炎症性肠病中的作用

doi:10.3760/cma.j.issn.1007-1245.2022.19.007

摘要/Abstract

摘要： 脑源性神经营养因子（brain-derived neurotrophic factor，BDNF）是神经营养因子（neurotrophin，NT）家族中的重要成员，在神经元的维持和存活，保持突触完整性和突触可塑性中起重要作用，但其作用不仅限于此。研究发现BDNF在炎症性肠病（inflammatory bowel disease，IBD）中具有维持内脏超敏反应，促进肠道动力，维持肠道屏障，调节情绪障碍及心脏功能的作用，可能在IBD的发生发展中起重要作用。虽然目前大多限于基础研究，但已经取得了一定的成果，可以预见BDNF将有很好的临床应用前景，可能为IBD的临床治疗提供新的治疗思路。对此，本文作一简要综述。

关键词: 脑源性神经营养因子, 炎症性肠病, 内脏超敏反应, 肠道动力, 肠道屏障

Abstract: Brain-derived neurotrophic factor (BDNF) is an important member of the neurotrophic factor family, and plays an important role in the maintenance and survival of neurons, as well as the maintenance of synaptic integrity and synaptic plasticity, but its role is not limited to these. Studies have found that BDNF plays a role in maintaining visceral hypersensitivity, promoting intestinal motility, maintaining intestinal barrier, and regulating mood disorders and heart function in patients with inflammatory bowel disease (IBD), and may play an important role in the occurrence and development of IBD. Although most of the studies are limited to basic research at present, some achievements have been made. It can be predicted that BDNF will have a good clinical application prospect and may provide a new treatment idea for the clinical treatment of IBD. In this paper, a brief review is made.

Key words: Brain-derived neurotrophic factor, Inflammatory bowel disease, Visceral supersensitivity, Intestinal dynamics, Intestinal barrier

中图分类号:

许瑞雪李琼羽连海峰. 脑源性神经营养因子在炎症性肠病中的作用[J]. 国际医药卫生导报, 2022, 28(19): 2694-2699.

Xu Ruixue, Li Qiongyu, Lian Haifeng. Role of brain-derived neurotrophic factor in inflammatory bowel disease [J]. International Medicine and Health Guidance News, 2022, 28(19): 2694-2699.

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