小建中汤加味治疗脾胃虚寒型中枢介导的腹痛综合征患者的效果

doi:10.3760/cma.j.issn.1007-1245.2024.23.025

国际医药卫生导报 ›› 2024, Vol. 30 ›› Issue (23): 4006-4009.DOI: 10.3760/cma.j.issn.1007-1245.2024.23.025

小建中汤加味治疗脾胃虚寒型中枢介导的腹痛综合征患者的效果

黄金红¹ 李伟之²

¹宝鸡市陈仓医院消化内科，宝鸡　721300；²西安交通大学第一附属医院消化内科，西安　710061

收稿日期:2024-04-28 出版日期:2024-12-01 发布日期:2024-12-16
通讯作者: 李伟之，Email：309983251@qq.com
基金资助:
陕西省重点研发计划（2021SF-126）

Modified Xiao Jianzhong decoction in treatment of patients with centrally mediated abdominal pain syndrome of spleen and stomach deficiency-cold type

Huang Jinhong¹, Li Weizhi²

¹Department of Gastroenterology, Baoji Chencang Hospital, Baoji 721300, China; ²Department of Gastroenterology, First Hospital, Xi'an Jiaotong University, Xi'an 710061, China

Received:2024-04-28 Online:2024-12-01 Published:2024-12-16
Contact: Li Weizhi, Email: 309983251@qq.com
Supported by:
Key Plan of Research and Development in Shaanxi (2021SF-126)

摘要/Abstract

摘要：

目的　观察小建中汤加味治疗脾胃虚寒型中枢介导的腹痛综合征（centrally mediated abdominal pain syndrome，CAPS）的临床效果。方法　选取宝鸡市陈仓医院2021年9月至2023年8月收治的68例脾胃虚寒型CAPS患者进行随机对照试验。采用随机数字表法将其分为对照组和观察组，各34例。对照组男18例，女6例，年龄（49.97±9.35）岁，病程6个月～8年；观察组男15例，女19例，年龄（51.68±11.83）岁，病程6个月～10年。对照组予以调节肠功能、解痉、益生菌调节肠道菌群等常规临床治疗，并加用多塞平抗焦虑治疗。观察组给予小建中汤加味治疗。比较两组疼痛量表评分、汉密顿焦虑量表（Hamilton Anxiety Scale，HAMA）评分、生活质量、治疗效果及用药不良反应。采用t检验、χ²检验进行统计分析。结果　治疗4周后，观察组疼痛量表评分、HAMA评分均低于对照组［（2.47±0.83）分比（4.03±1.00）分、（6.26±2.26）分比（9.21±2.19）分，均P<0.05］。观察组有效率高于对照组［94.12%（32/34）比73.53%（25/34），P=0.021］。观察组不良反应发生率低于对照组［17.65%（6/34）比76.47%（26/34），P<0.05］。观察组生活质量评分高于对照组［（88.94±1.59）分比（79.56±2.05）分，P<0.05］。结论　小建中汤加味治疗脾胃虚寒型CAPS患者能有效减轻其症状，改善患者生活质量，总体疗效更好，并且不良反应发生率较低。

关键词:

脾胃虚寒型, 中枢介导的腹痛综合征, 小建中汤, 郁证, 治疗效果

Abstract:

Objective　To observe the clinical efficacy of modified Xiao Jianzhong decoction for patients with centrally mediated abdominal pain syndrome (CAPS) of spleen and stomach deficiency-cold type. Methods　Sixty-eight patients with CAPS of spleen and stomach deficiency-cold type treated at Baoji Chencang Hospital from September 2021 to August 2023 were selected for the randomized controlled trial, and were divided into a control group and an observation group by the random number table method, with 34 cases in each group. There were 18 males and 16 females in the control group; they were (49.97±9.35) years old; their disease course was from 6 months to 8 years. There were 15 males and 19 females in the observation group; they were (51.68±11.83) years old; their disease course was from 6 months to 10 years. The control group were given routine clinical treatment, such as regulating intestinal function, antispasmodic, probiotics to regulate intestinal flora, etc. and took doxorubicin for anxiolytic treatment. The observation group took Xiao Jianzhong decoction. The scores of pain scale and Hamilton Anxiety Scale (HAMA), life quality, therapeutic effects, and adverse reactions were compared between the two groups. t and χ² tests were used for the statistical analysis. Results　After 4 weeks' treatment, the scores of pain scale and HAMA in the observation group were lower than those in the control group (2.47±0.83 vs. 4.03±1.00 and 6.26±2.26 vs. 9.21±2.19; both P<0.05). The effective rate in the observation group was higher than that in the control group [94.12% (32/34) vs. 73.53% (25/34); P=0.021]. The incidence rate of adverse reactions in the observation group was lower than that in the control group [17.65% (6/34) vs. 76.47% (26/34); P<0.05]. The score of life quality in the observation group was higher than that in the control group (88.94±1.59 vs. 79.56±2.05; P<0.05). Conclusion　Modified Xiao Jianzhong decoction for patients with CAPS of spleen and stomach deficiency-cold type can effectively alleviate their symptoms, improve their life quality, with better overall effectiveness and a lower incidence rate of adverse reactions.

Key words:

Spleen and stomach deficiency-cold type, Centrally mediated abdominal pain syndrome, Xiao Jianzhong decoction, Depression, , Therapeutic effect

黄金红李伟之.

小建中汤加味治疗脾胃虚寒型中枢介导的腹痛综合征患者的效果 [J]. 国际医药卫生导报, 2024, 30(23): 4006-4009.

Huang Jinhong, Li Weizhi.

Modified Xiao Jianzhong decoction in treatment of patients with centrally mediated abdominal pain syndrome of spleen and stomach deficiency-cold type [J]. International Medicine and Health Guidance News, 2024, 30(23): 4006-4009.

参考文献

[1] 杨旭,陈婉珍,朱方石.中枢介导的腹痛综合征中医临床研究进展[J].广西中医药,2021,44(3):72-74. DOI:10.3969/j.issn.1003-0719.2021.03.026.
[2] 郑天歌,张青杰,贾靖仪,等. 新型抗焦虑药物研究进展[J]. 中国药理学通报, 2021, 37 (9): 1188-1196. DOI:10.3969/j.issn.1001-1978.2021.09.002.
[3] 崔筱,刘亮. 辣椒素受体在腹泻型肠易激综合征发病中的作用[J]. 国际医药卫生导报,2024,30(7):1066-1070. DOI:10.3760/cma.j.issn.1007-1245.2024.07.003.
[4] 魏玮,罗晓颖,刘建平. 功能性胃肠病诊治现状及中医药治疗优势与展望[J]. 北京中医药, 2022, 41 (4): 348-350. DOI:10.16025/j.1674-1307.2022.04.001.
[5] Schmulson MJ, Drossman DA. What is new in Rome Ⅳ. J Neurogastroenterol Motil. 2017, 23(2):151-163. DOI: 10.5056/jnm16214.
[6] 吴勉华, 石岩. 中医内科学[M]. 中国中医药出版社有限公司, 2021.
[7] 张声生,刘凤斌,侯政昆. 脾胃病症状量化标准专家共识意见(2017) [J]. 中华中医药杂志, 2017, 32(8): 3590-3596.
[8] 林志亮,路聚保,陈启仪,等. 肠道菌群移植联合营养支持治疗和心理干预对"同济四联征"的临床疗效分析[J].中华胃肠外科杂志,2022,25(9):784-791. DOI:10.3760/cma.j.cn441530-20220605-00245.
[9] 钟华文,许英铭,罗立媛,等. 桂枝汤合小柴胡汤加减治疗寒邪内阻型功能性腹痛综合征的临床研究[J]. 中外医学研究,2021,19(24):97-99. DOI:10.14033/j.cnki.cfmr.2021. 24.032.
[10] 李宏,张晓莲. 乌梅丸加减治疗寒热错杂型功能性腹痛的临床效果[J]. 临床合理用药杂志,2021,14(32):85-87. DOI:10.15887/j.cnki.13-1389/r.2021.32.033.
[11] 中华医学会,中华医学会杂志社,中华医学会消化病学分会,等. 慢性腹痛基层诊疗指南(2019年)[J]. 中华全科医师杂志,2019,18(7):618-627. DOI:10.3760/cma.j.issn. 1671-7368.2019.07.003.
[12] 宋雨菲,魏凯峰. 小建中汤方证辨析[J]. 中国中医药现代远程教育, 2023, 21 (17): 69-72. DOI: 10.3969/j.issn. 1672- 2779.2023.17.025.
[13] 徐宁阳,任路,谷松,等. "建中-理中-补中"代表方在临床治疗双心疾病中的应用[J]. 中华中医药学刊, 2023, 41 (1): 148-150, 280. DOI: 10.13193/j.issn.1673-7717. 2023.01.033.
[14] 孔競谊,周永学. 小建中汤治疗郁证的机理探讨[J]. 时珍国医国药,2018,29(1):153-155. DOI: 10.3969/j.issn. 1008-0805.2018.01.054.
[15] 张明远,许二平,尚立芝,等.酸枣仁汤及其组分治疗抑郁症的研究进展[J].中华中医药学刊,2022,40(6):48-54. DOI: 10.13193/j.issn.1673-7717.2022.06.010
[16] 李兆珍,李炜,张丹参. 远志治疗抑郁症的药理研究[J]. 中国药理学与毒理学杂志, 2019, 33(9): 711-712.
[17] 王瑞敏,刘毅,李菲,等. 基于网络药理学探讨合欢皮-远志药对的抗抑郁作用[J]. 中医药临床杂志,2021,33(6):1098-1103. DOI:10.16448/j.cjtcm.2021.0624.

小建中汤加味治疗脾胃虚寒型中枢介导的腹痛综合征患者的效果

Modified Xiao Jianzhong decoction in treatment of patients with centrally mediated abdominal pain syndrome of spleen and stomach deficiency-cold type

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 7

编辑推荐

Metrics

[1]	马涛陆延娜白雪刘波. 强脉冲光联合重组人源Ⅲ型胶原蛋白贴敷料对玫瑰痤疮患者的影响 [J]. 国际医药卫生导报, 2024, 30(15): 2533-2538.
[2]	李胜利刘洋. 肩三针温针灸联合小针刀治疗肩周炎的临床效果观察 [J]. 国际医药卫生导报, 2023, 29(20): 2864-2868.
[3]	张力峰, 苏泉心, 高生林, 鹿超, 岳闯, 吴兴宇, 毛卫江, 左立. 改良阴茎成形术治疗青少年男性常见外生殖器畸形的疗效分析[J]. 国际医药卫生导报, 2022, 28(6): 745-748.
[4]	李富云, 薛麦富. 甲泼尼龙和利多卡因治疗难治性突发性聋伴耳鸣的效果[J]. 国际医药卫生导报, 2022, 28(6): 780-783.
[5]	叶东明, 赖彩永, 伍国豪, 陈智慧, 钟晓健. 尿管管腔内置斑马导丝对导尿困难患者的治疗效果观察[J]. 国际医药卫生导报, 2022, 28(5): 712-714.
[6]	杜江涛李扬欧阳山丹刘炳震林珍. 替加环素联合头孢哌酮舒巴坦治疗ICU重度腹腔感染的效果[J]. 国际医药卫生导报, 2022, 28(21): 3077-3081.
[7]	周珊汕, 吴智丹. 急性肾功能衰竭患者的综合护理干预分析[J]. 国际医药卫生导报, 2022, 28(2): 278-280.