关键词:

帕金森病, SAA, hs-CRP, IGF-1, 疾病进展

Abstract:

Objective　To investigate the serum levels of amyloid A (SAA), high-sensitivity C-reactive protein (hs-CRP), and insulin-like growth factor 1 (IGF-1) in patients with Parkinson's disease (PD) and their correlations with disease severity, and to assess the value of these biomarkers in the evaluating disease progression and providing prognostic guidance. Methods　A total of 122 patients with PD treated at Xidian Group Hospital from January 2021 to October 2023 were selected as an observation group, and were divided into an early-stage group (44 cases) and a middle-late stage group (78 cases) according to their disease severities. Among the 122 patients, there were 64 males and 58 females; they were (68.13±8.45) years old; their disease course was (6.06±2.71) years. Fifty healthy examinees during the same period were selected as a healthy control group, including 28 males and 22 females who were (67.25±7.59) years old. The levels of SAA, hs-CRP, and IGF-1 were compared between the 3 groups, and their correlations with the disease severity were analyzed. Multivariate regression analysis was employed to identify the risk factors influencing disease progression. The diagnostic values of SAA, hs-CRP, and IGF-1 in disease progression assessment were evaluated using the receiver operating characteristic curves (ROC). t and χ² tests were applied. Results　The levels of SAA and hs-CRP in the observation group were higher than those in the healthy control group [(9.53±1.50) mg/L vs. (3.71±1.06) mg/L and (5.37±2.74) mg/L vs. (0.82±0.29) mg/L; both P<0.05]; the level of IGF-1 in the observation group were lower than that in the healthy control group [(65.73±15.25) μg/L vs. (84.04±19.72) μg/L; P<0.05]. The disease severity was correlated with the levels of SAA, hs-CRP, and IGF-1 (r=0.587, 0.492, and -0.660; all P<0.05). The multifactorial regression analysis revealed that advanced age, long disease duration, high levels of SAA and hs-CRP, and a low level of IGF-1 were significant predictors of increased disease severity. The combined predictive model of SAA, hs-CRP, and IGF-1 showed an area under the curve (AUC) of 0.967, with a sensitivity of 92.3% and a specificity of 93.2%. Conclusion　The serum levels of SAA, hs-CRP, and IGF-1 are closely associated with the disease progression of patients with PD and can serve as important biomarkers for assessing disease progression.

Key words:

Parkinson's disease, SAA, hs-CRP, IGF-1, Disease progression