血清MBP、GLOⅠ、hs-CRP水平与糖尿病周围神经病变的相关性

doi:10.3760/cma.j.issn.1007-1245.2023.14.007

国际医药卫生导报 ›› 2023, Vol. 29 ›› Issue (14): 1955-1958.DOI: 10.3760/cma.j.issn.1007-1245.2023.14.007

血清MBP、GLOⅠ、hs-CRP水平与糖尿病周围神经病变的相关性

朱佩璇卢梅娟曹滨冬孟辉

前海人寿广州总医院国际医疗部，广州　511300

收稿日期:2022-05-09 出版日期:2023-07-15 发布日期:2023-07-31
通讯作者: 朱佩璇，Email：yiran68@163.com
基金资助:
广东省医学科研基金（C2021096）

Correlation between serum levels of MBP, GLOⅠ, and hs-CRP and diabetic peripheral neuropathy

Zhu Peixuan, Lu Meijuan, Cao Bindong, Meng Hui

Department of International Medical Therapy, Guangzhou General Hospital, Foresea Life Insurance, Guangzhou 511300, China

Received:2022-05-09 Online:2023-07-15 Published:2023-07-31
Contact: Zhu Peixuan, Email: yiran68@163.com
Supported by:
Medical Science and Technology Research Fund of Guangdong Province (C2021096)

摘要/Abstract

摘要：

目的　探讨血清髓鞘碱性蛋白（MBP）、乙二醛酶Ⅰ（GLOⅠ）、高敏-C反应蛋白（hs-CRP）水平与糖尿病周围神经病变（DPN）的相关性。方法　选取前海人寿广州总医院2021年7月至12月收治的DPN患者30例作为观察A组［男9例，女21例，年龄（60.46±11.65）岁，体质量指数（24.50±1.68）kg/m²］，无周围神经病变的糖尿病（DM）30例［男8例，女22例，年龄（54.12±10.47）岁，体质量指数（24.66±1.72）kg/m²］作为观察B组，同时选取同期健康体检者30例作为对照组［男11例，女19例，年龄（56.54±7.26）岁，体质量指数（25.01±1.86）kg/m²］。所有研究对象均检测血清MBP、GLOⅠ、hs-CRP水平，采用单因素方差分析比较3组研究对象血清MBP、GLOⅠ、hs-CRP水平，采用Pearson相关性分析血清MBP、GLOⅠ、hs-CRP水平与DPN的相关性。结果　观察A组MBP、hs-CRP水平高于观察B组、对照组，GLOⅠ水平低于观察B组、对照组（均P<0.05）；观察B组MBP、hs-CRP水平高于对照组，GLOⅠ水平低于对照组（均P<0.05）。Pearson相关性分析显示，血清MBP、hs-CRP水平与DPN呈正相关（r=0.297、0.615，均P<0.05），血清GLOⅠ水平与DPN呈负相关（r=-0.501，P<0.05）。结论　高MBP、hs-CRP水平、低GLOⅠ水平与DPN发生有关，检测血清MBP、GLOⅠ、hs-CRP水平有助于诊断DPN。

关键词:

糖尿病周围神经病变, 乙二醛酶Ⅰ, 髓鞘碱性蛋白, 高敏C反应蛋白

Abstract:

Objective　To investigate the correlation between serum levels of myelin basic protein (MBP), glyoxalase Ⅰ (GLOⅠ), and high-sensitivity-C-reactive protein (hs-CRP) and diabetic peripheral neuropathy (DPN). Methods　From July to December 2021, 30 patients with DPN treated at Guangzhou General Hospital, Foresea Life Insurance were selected as an observation group A [9 males and 21 females; (60.46±11.65) years old; their body mass index was (24.50±1.68) kg/m²], 30 patients with diabetes mellitus (DM) but no peripheral neuropathy as an observation group B [8 males and 22 females; (54.12±10.47) years old; their body mass index was (24.66±1.72) kg/m²], and 30 healthy persons taking physical examination as a control group [11 males and 19 females; (56.54±7.26) years old; their body mass index was (25.01±1.86) kg/m²]. The serum levels of MBP, GLOⅠ, and hs-CRP in all the subjects were detected. The serum levels of MBP, GLOⅠ, and hs-CRP in the three groups were compared by one way analysis of variance. The correlation between the serum levels of MBP, GLOⅠ, and hs-CRP and DPN was analyzed by Pearson correlation. Results　The levels of MBP and hs-CRP in the observation group A were higher than those in the observation group B and the control group, and the level of GLOⅠ was lower than those in the observation B and the control group (all P<0.05); the levels of MBP and hs-CRP in the observation group B were higher than those in the control group, and the level of GLOⅠ were lower than that in the control group (all P<0.05). Pearson correlation analysis showed that the serum MBP and hs-CRP levels were positively correlated with DPN (r=0.297 and 0.615, both P<0.05), and the serum GLOⅠ level was negatively correlated with DPN (r=-0.501, P<0.05). Conclusions　High levels of MBP and hs-CRP and low GLOⅠ level are associated with the occurrence of DPN. The detection of serum levels of MBP, GLOⅠ, and hs-CRP is helpful in diagnosing DPN.

Key words:

Diabetic peripheral neuropathy, Glyoxalase Ⅰ, Serum myelin basic protein, High-sensitivity-C-reactive protein

朱佩璇卢梅娟曹滨冬孟辉.

血清MBP、GLOⅠ、hs-CRP水平与糖尿病周围神经病变的相关性 [J]. 国际医药卫生导报, 2023, 29(14): 1955-1958.

Zhu Peixuan, Lu Meijuan, Cao Bindong, Meng Hui.

Correlation between serum levels of MBP, GLOⅠ, and hs-CRP and diabetic peripheral neuropathy [J]. International Medicine and Health Guidance News, 2023, 29(14): 1955-1958.

参考文献

[1] Jaiswal M, Divers J, Dabelea D, et al. Prevalence of and risk factors for diabetic peripheral neuropathy in youth with type 1 and type 2 diabetes: SEARCH for diabetes in youth study [J]. Diabetes Care, 2017, 40(9): 1226-1232. DOI: 10.2337/dc17-0179.
[2] 金洁雯,李延兵. 论糖尿病周围神经病变的诊治要点[J]. 实用医学杂志,2022,38(14):1715-1719. DOI:10.3969/j.issn.1006-5725.2022.14.001.
[3] 中华中医药学会糖尿病基层防治专家指导委员会. 国家糖尿病基层中医防治管理指南(2022)[J]. 中华糖尿病杂志,2023,15(2):100-117. DOI:10.13288/j.11-2166/r. 2022.24.017.
[4] 中华医学会眼科学分会眼底病学组,中国医师协会眼科医师分会眼底病学组. 我国糖尿病视网膜病变临床诊疗指南(2022年)[J]. 中华眼底病杂志,2023,39(2):99-124. DOI:10.3760/cma.j.cn511434-20230110-00018.
[5] 宋海英,常文利,牛向宏,等. 急性脑梗死后运动障碍和神经功能恶化与H-FABP、MBP及BDNF的相关性分析[J]. 脑与神经疾病杂志,2021,29(2):111-115.
[6] 罗贵聪,任建伟,陈为,等. 自发性脑出血患者血清NSE、MBP含量与神经功能障碍的相关性[J]. 中国继续医学教育,2021,13(17):99-103. DOI:10.3969/j.issn.1674-9308. 2021.17.028.
[7] 韩举风,熊伟,赵晓瑞. 神经传导、血清Hs-CRP联合CysC对糖尿病早期周围神经病变的诊断价值分析[J]. 四川生理科学杂志,2023,45(2):275-277.
[8] Mahdavifard S, Nakhjavani M. Thiamine pyrophosphate improved vascular complications of diabetes in rats with type 2 diabetes by reducing glycation, oxidative stress, and inflammation markers [J]. Med J Islam Repub Iran, 2020, 34:47. DOI: 10.34171/mjiri.34.47.
[9] 张雪利. 乙二醛酶I在糖尿病痛性神经病变患者中的变化及临床意义[J]. 智慧健康, 2020, 6(22): 149-151. DOI:10.19335/j.cnki.2096-1219.2020.22.061.

血清MBP、GLOⅠ、hs-CRP水平与糖尿病周围神经病变的相关性

Correlation between serum levels of MBP, GLOⅠ, and hs-CRP and diabetic peripheral neuropathy

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