关键词:

腹腔镜胆囊切除, 不良反应发生率, 氢吗啡酮, 酮咯酸氨丁三醇, 镇静效果

Abstract:

Objective　To explore the value applying hydromorphone combined with ketorolac tromethamine in analgesia for patients undergoing laparoscopic cholecystectomy. Methods　One hundred and twelve patients who took laparoscopic cholecystectomy in Linyi Central Hospital from July 2020 to June 2022 were selected for the randomized controlled trial. They were divided into a study group and a conventional group by the random number table method, with 56 cases in each group. There were 34 males and 22 females in the study group; they were (59.36±12.36) years old. There were 33 males and 23 females in the conventional group; they were (59.96±13.52) years old. The study group were anesthetized with hydromorphone and ketorolac tromethamine, and the conventional group with ketorolac tromethamine. The hospital stays, operation times, postoperative pain degrees [score of Visual Analog Scale (VAS)], and adverse reactions of the two groups were observed. t and χ² tests were applied. Results　The hospital stay in the study group was shorter than that in the conventional group [(5.58±3.01) d vs. (8.52±3.14) d; t=5.058, P<0.001]. The VAS scores in both group were lower 9 than 6 h after the operation; the VAS scores 6 and 9 h after the operation in the study group were lower than those in the conventional group (t=37.133 and 26.641, both P<0.001). The incidence of adverse reactions in the study group was lower than that in the conventional group [5.36% (3/56) vs. 17.86% (10/56); χ²=4.264, P=0.039]. Conclusion　For patients undergoing laparoscopic cholecystectomy, 0.04 mg/kg hydromorphone combined with 0.5 mg/kg ketorolac tromethamine can promote their recovery and reduce the incidence of adverse reactions, and has significant sedative effect, so it is worthy of promotion.

Key words:

Laparoscopic cholecystectomy, Incidence of adverse reactions, Hydromorphone, Ketorolac tromethamine, Sedative effect