关键词:

地骨皮, 中医传承计算平台, 数据挖掘, 临床分析, 组方规律

Abstract:

Objective　To explore the potential rules of Cortex Lycii in 6 783 prescriptions of Yin deficiency syndrome, so as to provide the theoretical basis and reference for clinical application and pharmacological research of Cortex Lycii. Methods　The cases involved in this study were provided by Fujian Provincial People's Hospital. A total of 6 783 prescriptions of Yin deficiency syndrome containing Cortex Lycii from 2018 to 2020 were collected. and input into the traditional Chinese Medicine (TCM) inheritance calculation platform to establish the database. The frequencies of symptom types, main TCM diseases, and main diseases were counted. The overall drugs, the core medicinal materials and their combination rules in the treatment of Yin deficiency syndrome were statistically analyzed under different support degrees when the confidence was 0.9. Finally, the core medicinal materials and their combination rules of Cortex Lycii in high-frequency applied syndrome types were further statistically analyzed by the Apriori association rule algorithm. Results　The Yin deficiency syndrome mainly treated was highly concentrated in the liver and kidney. There were 5 kinds of diseases with frequency ≥200, among which the top three with the highest frequencies were Xiaoke disease, white astringent disease, and gall disease. There were 741 kinds of diseases, the top three with the highest frequencies were type 2 diabetes mellitus, xerophthalmia, and conjunctivitis. Baishao, Radix Rehmanniae, and Huangqi were the top three with the highest compatibility frequency in the prescription of Yin deficiency syndrome. Its core combinations were Cortex Lycii - Baishao, Cortex Lycii – Radix Rehmanniae, and Cortex Lycii - Huangqi. The core compatible herbs in the Qi and Yin deficiency syndrome mainly included Huangqi, Zhimu, Baishao, Poria Cocos, and Chuanxiong. The core combinations were Cortex Lycii - Huangqi - Zhimu, Cortex Lycii - Poria Cocos, Cortex Lycii - Zhimu, Huangqi - Zhimu, Cortex Lycii - Baishao, Cortex Lycii - Huangqi, Cortex Lycii - Chuanxiong. Among which, Cortex Lycii – Chuanxiong and Huangqi - Zhimu had special synergistic significance in the Qi and Yin deficiency syndrome. In the liver Yin deficiency syndrome, the core compatible herbs were Baishao, Radix Scrophulariae, and Radix Rehmanniae (with a support degree up to 60%). Its core combinations were Cortex Lycii – Baishao - Radix Scrophulariae, Cortex Lycii - Baishao - Radix Rehmanniae, Baishao - Radix Scrophulariae, Cortex Lycii – Baishao, Cortex Lycii - Radix Rehmanniae, Cortex Lycii - Radix Scrophulariae, and Baishao - Radix Rehmanniae. In the kidney Yin deficiency syndrome, there were four core compatible herbs, namely Baishao, Maidong, Radix Rehmanniae, and Radix scrophulariae (with a support degree up to 40%). The core combinations were Cortex Lycii – Baishao, Cortex Lycii - Radix Rehmanniae, Cortex Lycii – Maidong, and Cortex Lycii - Radix Scrophulariae. Among which, Radix Rehmanniae - Maidong and Radix Rehmanniae - Radix Scrophulariae were often used in pairs and compatible with Cortex Lycii (with a support degree up to 40%). Conclusion　Based on a large number of clinical prescriptions, this analysis of actual use of Cortex Lycii in the Yin deficiency syndrome shows the prescription law of Cortex Lycii in the treatment of Yin deficiency syndrome and the core combination law of Yin deficiency syndrome of different viscera for the first time, which can provide ideas and basis for modern clinical application and modern pharmacological research of Cortex Lycii.

Key words:

Cortex Lycii, TCM heritage computing platform, Data mining, Clinical analysis, Prescription rules