国际医药卫生导报 ›› 2023, Vol. 29 ›› Issue (6): 741-744.DOI: 10.3760/cma.j.issn.1007-1245.2023.06.001

• 医学新进展 •    下一篇

桥本甲状腺炎的研究进展

姚文杰1  宋凯雨2  姜冠桐3  陈茜1  周瑾2   

  1. 1滨州医学院第二临床医学院,烟台 2640032烟台毓璜顶医院内分泌科,烟台 2640003烟台海港医院内分泌科,烟台 264000

  • 收稿日期:2022-11-23 出版日期:2023-03-15 发布日期:2023-04-02
  • 通讯作者: 周瑾,Email:zhoujinsy@163.com
  • 基金资助:

    国家自然科学基金(81700695);国家留学基金公派留学项目(201909370036

Research progress of Hashimoto's thyroiditis

Yao Wenjie1, Song Kaiyu2, Jiang Guantong3, Chen Xi1, Zhou Jin2   

  1. 1 Second Medical College, Binzhou Medical University, Yantai 264003, China; 2 Department of Endocrinology, Yantai Yuhuangding Hospital, Yantai 264000, China; 3 Department of Endocrinology, Yantai Haigang Hospital, Yantai 264000, China

  • Received:2022-11-23 Online:2023-03-15 Published:2023-04-02
  • Contact: Zhou Jin, Email: zhoujinsy@163.com
  • Supported by:

    National Natural Science Foundation (81700695); Public Dispatch Project Supported by National Scholarship Fund (201909370036)

摘要:

桥本甲状腺炎以甲状腺特异性自身抗体为特征,是最常见的自身免疫性疾病之一。近年来其患病率急剧增加,并逐渐成为社会所关注的热点话题。这篇文献综述从影响疾病的免疫因素、自噬及凋亡3个方面介绍了桥本甲状腺炎的发病机制,期望能够更深入了解该疾病,从而更好地指导临床工作。

关键词:

桥本甲状腺炎, 免疫因素, 自噬, 凋亡

Abstract:

Hashimoto's thyroiditis is characterized by thyroid-specific autoantibodies and is one of the most common autoimmune diseases. In recent years, its prevalence is increasing dramatically and has gradually become a hot topic in the society. This literature review introduces the pathogenesis of Hashimoto's thyroiditis from three aspects: immune factors, autophagy, and apoptosis affecting the disease, hoping to gain a deeper understanding of the disease and to better guide clinical work.

Key words:

Hashimoto's thyroiditis, Immune factors, Autophagy, Apoptosis