关键词:

腹泻, 锌制剂, 酪酸梭菌二联活菌制剂, 微炎症指标, 儿童

Abstract:

Objective　To investigate the effect of zinc preparation combined with clostridium butyricum bifunctional viable preparation on clinical symptom relief time and micro inflammation indexes in children with diarrhea. Methods　It was a prospective randomized controlled trial. A total of 79 children with diarrhea who visited Yudu Maternal and Child Health Hospital from March 2021 to May 2022 were divided into a control group (40 cases) and an experimental group (39 cases) by the random number table method. In the control group, there were 22 males and 18 females, with an age of (21.36±4.25) months old. There were 20 males and 19 females in the experimental group, with an age of (21.47±4.35) months old. Both groups were given routine treatment. On the basis of routine treatment, the control group was given zinc preparation, and the experimental group was given zinc preparation combined with clostridium butyricum bifunctional viable preparation for 7 days. The symptom relief time, blood zinc level, immune function [immunoglobulin A (IgA), IgM, and IgG], micro inflammation indicators [interleukin-10 (IL-10), IL-6, and tumor necrosis factor α (TNF-α)], and adverse reactions were compared between the two groups. t test and χ² test were used. Results　After treatment, the time of stool examination returning to normal [(5.19±1.26) d], temperature recovery time [(3.63±1.09) d], vomiting relief time [(1.55±0.48) d], and abdominal pain relief time [(1.37±0.40) d] of the experimental group were shorter than those of the control group [(8.35±1.51) d, (5.56±1.18) d, (3.08±0.91) d, and (2.79±0.81) d], with statistically significant differences (all P<0.05). After treatment, the levels of IgA [(1.80±0.55) g/L], IgM [(16.08±1.24) g/L], IgG [(1.63±0.51) g/L], and blood zinc [(66.48±10.14) μmol/L] in the experimental group were higher than those in the control group [(1.49±0.48) g/L, (14.26±1.13) g/L, (1.35±0.40) g/L, and (57.24±9.36) μmol/L], with statistically significant differences (all P<0.05). After treatment, the levels of IL-6 [(14.24±3.66) ng/L] and TNF-α [(1.73±0.53) mg/L] in the experimental group were lower than those in the control group [(19.15±4.50) ng/L and (3.19±0.86) mg/L], and the IL-10 level [(33.09±4.32) ng/L] was higher than that in the control group [(26.76±3.18) ng/L], with statistically significant differences (all P<0.05). Conclusion　Zinc preparation combined with clostridium butyricum bifunctional viable preparation can regulate the blood zinc level and micro inflammatory reaction in children with diarrhea, enhance the body immunity, and accelerate the clinical symptom relief, with good safety.

Key words:

Diarrhea, Zinc preparation, Clostridium butyricum bifunctional viable preparation, Micro inflammatory indicators, Children