小分子热休克蛋白与肿瘤凋亡关系的研究进展

doi:10.3760/cma.j.issn.1007-1245.2023.03.001

国际医药卫生导报 ›› 2023, Vol. 29 ›› Issue (3): 297-301.DOI: 10.3760/cma.j.issn.1007-1245.2023.03.001

• 医学新进展 • 下一篇

小分子热休克蛋白与肿瘤凋亡关系的研究进展

王怡民李清华

桂林医学院附属医院神经内科广西神经系统疾病临床医学研究中心桂林医学院广西脑与认知神经科学重点实验室，桂林　541001

收稿日期:2022-10-11 出版日期:2023-02-01 发布日期:2023-03-02
通讯作者: 李清华，Email：qhli1999@163.com
基金资助:
国家自然科学基金资助项目（82160520）；中央引导地方科技发展资金项目（桂科ZY21195042）；广西科技计划项目（桂科AD17129015）；广西神经系统疾病大数据智能云管理重点实验室项目（ZTJ2020005）

Advances in the relationships between small heat shock proteins and tumor apoptosis

Wang Yimin, Li Qinghua

Department of Neurology, Affiliated Hospital of Guilin Medical University, Guangxi Clinical Medical Research Center of Neurological Diseases, Guangxi Key Laboratory of Brain and Cognitive Neuroscience, Guilin Medical University, Guilin 541001, China

Received:2022-10-11 Online:2023-02-01 Published:2023-03-02
Contact: Li Qinghua, Email: qhli1999@163.com
Supported by:
National Natural Science Foundation of China (82160520); Project of Government Guided Local Science and Technology Development Fund (ZY21195042); Guangxi Science and Technology Planning Project (AD17129015); Project of Guangxi Key Laboratory of Big Data Intelligent Cloud Management for Neurological Diseases (ZTJ2020005)

摘要/Abstract

摘要：

小分子热休克蛋白（small heat shock proteins，sHSPs）是众多热休克蛋白（heat shock proteins，HSPs）中的一大类，包括HSPB1、HSPB5、HSPB6、HSPB8等。近来研究表明，它们在许多信号通路扮演关键角色，这些信号通路与肿瘤的发生、抗放疗和凋亡的抑制有着许多联系，尤其是在肿瘤凋亡方面。本文对sHSPs在肿瘤凋亡途径方面予以综述。

关键词:

小分子热休克蛋白, 肿瘤, 凋亡, 热诱导

Abstract:

Small heat shock proteins (sHSPs) are a large group of many heat shock proteins (HSPs), including HSPB1, HSPB5, HSPB6, and HSPB8. Recent studies have shown that they play key roles in many signaling pathways that have many connections with tumorigenesis, anti-radiation, and apoptosis inhibition, especially in tumor apoptosis. In this paper, the effects of sHSPs on tumor apoptosis pathways are reviewed.

Key words:

Small heat shock proteins, , Tumor, , Apoptosis, , Heat inducing

王怡民李清华.

小分子热休克蛋白与肿瘤凋亡关系的研究进展 [J]. 国际医药卫生导报, 2023, 29(3): 297-301.

Wang Yimin, Li Qinghua.

Advances in the relationships between small heat shock proteins and tumor apoptosis [J]. International Medicine and Health Guidance News, 2023, 29(3): 297-301.

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小分子热休克蛋白与肿瘤凋亡关系的研究进展

Advances in the relationships between small heat shock proteins and tumor apoptosis

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