关键词: 乳腺癌, 病理诊断, 免疫组织化学检测

Abstract: Objective　To analyze the clinical effect of immunohistochemical detection in the pathological diagnosis of breast cancer. Methods　The subjects of the study were 241 female breast cancer patients who were admitted to Zhongshan Hospital, Dalian University from January 1, 2019 to August 1, 2021. All the patients underwent surgical treatment after enrollment. According to the surgical resection of breast tumor specimens, the ER+ (estrogen receptor positive) PR+ (progesterone receptor positive) patients were included in the positive group (121 cases), and the ER- (estrogen receptor negative) and PR- (progesterone receptor negative) patients were included in the negative group (120 cases). The positive group were (56.87±4.35) years old, and the negative group (57.13±4.46). Both groups underwent immunohistochemical detection, and the results were compared. The independent-sample t test was applied. Results　The proportions of HER-2 (human epidermal growth factor receptor) (+) and HER-2 (-) of breast tumor specimens and the axillary lymph node metastasis rate were 23.96% (29/121), 76.03% (92/121), and 31.40% (38/121) in the positive group, and were 85.00% (102/120), 15.00% (18/120), and 65.83% (79/120) in the negative group, with statistical differences (all P<0.05). Conclusion　Immunohistochemical detection can provide effective references for the pathological diagnosis of breast cancer, clarify the positive rate of HER-2 and axillary lymph node metastasis, and point out an accurate direction for further clinical intervention, and is conducive to the improvement of the prognosis.

Key words: Breast cancer, Pathological diagnosis, Immunohistochemical detection