关键词: 无创高频振荡通气, 足月儿, 轻度急性呼吸窘迫综合征, 应用价值

Abstract: Objective　To study the value of noninvasive high frequency oscillatory ventilation in the treatment of term infants with mild acute respiratory distress syndrome (ARDS). Methods　A total of 60 term infants with mild ARDS treated in Gaoming District People's Hospital of Foshan from February to December 2021 were divided into a double level group and a high frequency group by the random number table, with 30 cases in each group. In the double level group, the ratio of male to female was 18:12, and the gestational age was (36.41±2.94) weeks; in the high frequency group, the ratio of male to female was 19:11, and the gestational age was (36.58±3.05) weeks. The infants in the double level group were treated with noninvasive double level positive pressure ventilation and the infants in the high frequency group were treated with noninvasive high frequency oscillatory ventilation. The blood gas analysis indexes, oxygenation indexes at different time points, clinical indexes, complications, and clinical treatment effects of the two groups were compared. The measurement data were tested by independent sample t test, and the count data were tested by χ² test. Results　In terms of blood gas analysis indexes, the arterial carbon dioxide partial pressure (PaCO₂) in the high-frequency group was lower than that in the double-level group, with a statistically significant difference between the two groups (P<0.05). After 24 h and 48 h, the oxygenation indexes of the two groups continued to decrease, and the oxygenation index in the high frequency group was significantly lower than that in the double level group (all P<0.05), with better oxygenation improvement. There were no statistically significant differences in the total oxygen inhalation time, total noninvasive respiratory support time, and total hospital stay between the two groups (all P>0.05). The rate of endotracheal intubation in the high frequency group [6.67% (2/30)] was lower than that in the double level group [26.67% (8/30)], with a statistically significant difference (P<0.05). The incidence of complications was 3.33% (1/30) in the high frequency group and 13.33% (4/30) in the double level group, without statistically significant difference between the two groups (P>0.05). The effective rate of the high frequency group [93.33% (28/30)] was higher than that of the double level group [73.33% (22/30)], with a statistically significant difference between the two groups (P<0.05). Conclusion　The effect of noninvasive high-frequency oscillatory ventilation in the treatment of term infants with mild ARDS is ideal, and it can improve their oxygenation and blood gas indexes, with high safety and high feasibility.

Key words: Noninvasive high frequency oscillatory ventilation, Term infants, Mild acute respiratory distress syndrome, Application value