关键词: 幽门螺杆菌, 公职人员, 感染率, 检测指标

Abstract: Objective To analyze the Helicobacter pylori (Hp) infection and related influencing factors among public officials in Guangzhou, so as to provide decision-making basis for the scientific prevention and treatment of Hp. Methods The physical examination data of 6 436 public officials in Guangzhou who underwent physical examination and 13C urea breath test in Guangzhou Cadre Health Management Center from January to December 2020 were collected and analyzed retrospectively, including 3 535 males and 2 901 females, aged (45.33±11.38) years. The situation of Hp infection and the relationships between Hp infection and gender, age, body mass index (BMI), blood pressure, blood glucose, blood lipid, urea, creatinine, uric acid, and other factors were analyzed by Chi square test and binary logistic regression analysis. Results The infection rate of Hp was 30.53% (1 965/6 436) among 6 436 subjects, of which the male infection rate was 31.40% (1 110/3 535), and the female infection rate was 29.47% (855/2 901). The positive rates of Hp in males and females were 32.27% (384/1 190) and 27.06% (204/754) in the 40-49 years old group, respectively, with a statistically significant difference (P=0.015); there was no statistically significant difference in the positive rate of Hp between males and females in the other age groups (P>0.05). The male and female BMI of the Hp positive group were (24.86±2.94) kg/m2 and (22.42±2.81) kg/m2 , respectively, which were higher than those of the Hp negative group [(24.65±2.82) kg/m2 and (22.19±2.87) kg/m2 ]; the diastolic blood pressure and triglyceride in the male Hp positive group were (74.75±10.20) mmHg (1 mmHg=0.133 kPa) and (1.74±1.62) mmol/L, respectively, which were higher than those in the Hp negative group [(74.02±9.89) mmHg and (1.60±1.58) mmol/L]; the level of uric acid in the female Hp positive group was (326.22±76.27) μmol/L, which was higher than that in the Hp negative group [(318.54±71.84) μmol/L], with statistically significant differences (all P< 0.05). Multivariate logistic regression analysis showed that Hp infection had no correlation with gender, age, BMI, blood pressure, blood glucose, blood lipid, or uric acid (all P>0.05), but blood urea (OR=0.920, P<0.01) and creatinine (OR=1.007, P<0.05) were affected. Conclusions There are no significant gender or age differences in the infection rate of Hp among public officials in Guangzhou, and there are no significant differences in the metabolic indexes among Hp infected population, but the blood urea level and creatinine level are affected.

Key words: Helicobacter pylori, Public officials, Infection rate, Detection index