关键词: 丛集性头痛, 维拉帕米, 泼尼松

Abstract: Objective To explore the clinical efficacy and safety of verapamil hydrochloride combined with prednisone in the preventive treatment of cluster headache. Methods A total of 43 patients with cluster headache in Shenyang Red Cross Hospital from March 2020 to March 2021 were randomly divided into an observation group (22 cases) and a control group (21 cases) with the random number table method. There were 17 males and 5 females in the observation group, aged (42.26±12.75) years; there were 14 males and 7 females in the control group, aged (39.26±11.38) years. The observation group was treated with verapamil combined with prednisone, while the control group was treated with verapamil. After two weeks of treatment, the durations of cluster period, headache frequencies, and adverse reactions of the two groups were recorded. Independent sample t test was used for inter-group comparison of measurement data, paired t test was used for intra-group comparison of measurement data, and χ2 test was used for count data. Results Compared with that before the treatment, the pain degree of patients in the observation group and the control group relieved after the treatment, with the total effective rate of 90.91% (20/22) in the observation group and 61.90% (11/21) in the control group, with a statistically significant difference between the two groups (P<0.05). Compared with those before the treatment, the frequencies of headache attack and the durations of cluster period in the two groups decreased after the treatment, and the differences of the two groups before and after the treatment were statistically significant (all P<0.05), and there were statistically significant differences between the observation group and the control group after the treatment (both P<0.05). No serious adverse reactions occurred in both groups during the treatment. Conclusions Verapamil combined with prednisone can prevent cluster headache, and can obviously reduce the duration of cluster period and the frequency of pain attack, and improve the clinical symptoms. Meanwhile, it has good safety and better effect than verapamil alone.

Key words: Cluster headache, Verapamil, Prednisone