磁共振波谱评价分布式智能交互穴电促醒系统对意识障碍患者的促醒疗效

doi:10.3760/cma.j.cn441417-20250604-21015

摘要/Abstract

摘要： 目的　分析磁共振波谱评价分布式智能交互穴电促醒系统对意识障碍患者的促醒疗效。方法　选取2022年6月至2024年12月陕西省中医医院收治的124例意识障碍患者，采用随机数字表法分为对照组和研究组，各62例。对照组：男35例、女27例，年龄（45.00±21.60）岁；研究组男33例、女29例，年龄（45.50±20.40）岁。对照组接受常规治疗，研究组在对照组基础上接受分布式智能交互穴电促醒系统治疗。对比两组治疗前后脑代谢指标、脑血流灌注情况、脑干听觉诱发电位（BAEP）各波潜伏期、SEP N20波潜伏期、脑电图（EEG）、格拉斯哥昏迷量表（GCS）、改良国际昏迷恢复量表（CRS-R）评分，以及临床疗效。统计学方法采用t检验、卡方检验。结果　研究组总有效率高于对照组［96.77%（60/62）比88.70%（52/62）］，差异有统计学意义（χ²=5.904，P<0.05）。治疗后，研究组N-乙酰天冬氨酸（NAA）/肌酐（Cr）、脑血容量（CBV）、脑血流量（CBF）较高，胆碱（Cho）/Cr、平均通过时间（MTT）均低于对照组，差异均有统计学意义（均P<0.05）；研究组Ⅰ波、Ⅲ波、Ⅴ波均低于对照组，差异均有统计学意义（t=8.384、14.990、20.540，均P<0.05）。治疗后，研究组N20波低于对照组［（15.51±0.60）ms比（18.43±0.86）ms］，差异有统计学意义（t=21.930，P<0.05）；研究组EEG、GCS、CRS-R评分均高于对照组［（1.89±0.58）分比（1.37±0.35）分、（12.54±1.86）分比（8.46±1.57）分、（9.84±1.75）分比（7.49±1.46）分］，差异均有统计学意义（t=6.044、13.200、8.119，均P<0.05）。结论　分布式智能交互穴电促醒系统能够改善意识障碍患者的脑代谢、脑血流灌注、神经电生理及临床评分，从而提高患者的促醒效果。

关键词: 磁共振波谱, 分布式智能交互, 电刺激, 意识障碍, 促醒

Abstract:

Objective　To analyze the magnetic resonance spectroscopy to evaluate the efficacy of the distributed intelligent interactive electro-stimulating awakening system in promoting awakening in patients with consciousness disorders. Methods　A total of 124 patients with consciousness disorders who were admitted to Shaanxi Provincial Hospital of Traditional Chinese Medicine from June 2022 to December 2024 were selected. They were randomly divided into the control group and the study group, with 62 cases in each group. Control group: 35 males and 27 females, with an age of (45.00±21.60) years. The research group consisted of 33 males and 29 females, with an average age of (45.50±20.40) years. The control group received conventional treatment, while the research group received treatment with the distributed intelligent interactive electro-stimulatory arousal system in addition to the treatment received by the control group. Compare the brain metabolic indicators, cerebral blood flow perfusion conditions, latencies of each wave of brainstem auditory evoked potential (BAEP), latency of SEP N20 wave, electroencephalogram (EEG), Glasgow Coma Scale (GCS), Modified International Coma Recovery Scale (CRS-R) score, and clinical efficacy before and after treatment in the two groups. Statistical methods employed t-test and χ² test. Results　The total effective rate of the research group was higher than that of the control group [96.77% (60/62) vs. 88.70% (52/62)], and the difference was statistically significant (χ²= 5.904, P<0.05). After treatment, compared with the control group, the study group showed higher levels of N-acetylaspartate (NAA) / creatinine (Cr), cerebral blood volume (CBV), and cerebral blood flow (CBF), while choline (Cho) / Cr and mean transit time (MTT) were lower. All these differences were statistically significant (all P<0.05). The wave I, wave Ⅲ and wave V of the research group were all lower than those of the control group, and the differences were statistically significant (t= 8.384, 14.990,and 20.540, all P<0.05). After treatment, the N20 wave in the study group was lower than that in the control group [(15.51±0.60) ms vs. (18.43±0.86) ms], and the difference was statistically significant (t= 21.930, P<0.05). The scores of EEG, GCS and CRS-R in the research group were all higher than those in the control group [(1.89±0.58) points vs. (1.37±0.35) points, (12.54±1.86) points vs. (8.46±1.57) points, (9.84±1.75) points vs. (7.49±1.46) points], and the differences were statistically significant (t=6.044, 13.200,and 8.119, all P<0.05). Conclusion　The distributed intelligent interactive electro-stimulating awakening system can improve the brain metabolism, cerebral blood flow perfusion, neuroelectrophysiological functions and clinical scores of patients with consciousness disorders, thereby enhancing the awakening effect of these patients.

Key words: Magnetic resonance spectroscopy, Distributed intelligent interaction, Electrical stimulation, Disturbance of consciousness, Wake up

曹妍杰万兆新. 磁共振波谱评价分布式智能交互穴电促醒系统对意识障碍患者的促醒疗效[J]. 国际医药卫生导报, 2025, 31(21): 3597-3602.

Cao Yanjie, Wan Zhaoxin. Evaluation of the effect of distributed intelligent interactive acupoint electrical awakening system on awakening in patients with disorders of consciousness by magnetic resonance spectroscopy[J]. International Medicine and Health Guidance News, 2025, 31(21): 3597-3602.

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